ID A0A016V813_9BILA Unreviewed; 992 AA.
AC A0A016V813;
DT 11-JUN-2014, integrated into UniProtKB/TrEMBL.
DT 11-JUN-2014, sequence version 1.
DT 27-MAR-2024, entry version 37.
DE RecName: Full=STAS domain-containing protein {ECO:0000259|PROSITE:PS50801};
GN Name=Acey_s0015.g2841 {ECO:0000313|EMBL:EYC23809.1};
GN Synonyms=Acey-sulp-6 {ECO:0000313|EMBL:EYC23809.1};
GN ORFNames=Y032_0015g2841 {ECO:0000313|EMBL:EYC23809.1};
OS Ancylostoma ceylanicum.
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Rhabditina; Rhabditomorpha; Strongyloidea; Ancylostomatidae;
OC Ancylostomatinae; Ancylostoma.
OX NCBI_TaxID=53326 {ECO:0000313|EMBL:EYC23809.1, ECO:0000313|Proteomes:UP000024635};
RN [1] {ECO:0000313|Proteomes:UP000024635}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=HY135 {ECO:0000313|Proteomes:UP000024635};
RX PubMed=25730766; DOI=10.1038/ng.3237;
RA Schwarz E.M., Hu Y., Antoshechkin I., Miller M.M., Sternberg P.W.,
RA Aroian R.V.;
RT "The genome and transcriptome of the zoonotic hookworm Ancylostoma
RT ceylanicum identify infection-specific gene families.";
RL Nat. Genet. 47:416-422(2015).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141,
CC ECO:0000256|RuleBase:RU362052}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004141, ECO:0000256|RuleBase:RU362052}.
CC -!- SIMILARITY: Belongs to the SLC26A/SulP transporter (TC 2.A.53) family.
CC {ECO:0000256|RuleBase:RU362052}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:EYC23809.1}.
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DR EMBL; JARK01001351; EYC23809.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A016V813; -.
DR STRING; 53326.A0A016V813; -.
DR Proteomes; UP000024635; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0008509; F:monoatomic anion transmembrane transporter activity; IEA:UniProtKB-UniRule.
DR GO; GO:0098661; P:inorganic anion transmembrane transport; IEA:UniProtKB-UniRule.
DR CDD; cd07042; STAS_SulP_like_sulfate_transporter; 1.
DR Gene3D; 3.30.750.24; STAS domain; 1.
DR InterPro; IPR011547; SLC26A/SulP_dom.
DR InterPro; IPR001902; SLC26A/SulP_fam.
DR InterPro; IPR002645; STAS_dom.
DR InterPro; IPR036513; STAS_dom_sf.
DR PANTHER; PTHR11814:SF105; PROTEIN CBR-SULP-6; 1.
DR PANTHER; PTHR11814; SULFATE TRANSPORTER; 1.
DR Pfam; PF01740; STAS; 1.
DR Pfam; PF00916; Sulfate_transp; 1.
DR SUPFAM; SSF52091; SpoIIaa-like; 1.
DR PROSITE; PS50801; STAS; 1.
PE 3: Inferred from homology;
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|RuleBase:RU362052};
KW Reference proteome {ECO:0000313|Proteomes:UP000024635};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW ECO:0000256|RuleBase:RU362052};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|RuleBase:RU362052}; Transport {ECO:0000256|RuleBase:RU362052}.
FT TRANSMEM 204..224
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362052"
FT TRANSMEM 230..246
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362052"
FT TRANSMEM 310..333
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362052"
FT TRANSMEM 386..408
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362052"
FT TRANSMEM 420..437
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362052"
FT TRANSMEM 470..488
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362052"
FT TRANSMEM 543..563
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362052"
FT TRANSMEM 602..632
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362052"
FT DOMAIN 656..831
FT /note="STAS"
FT /evidence="ECO:0000259|PROSITE:PS50801"
FT REGION 1..87
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 835..860
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 883..992
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1..40
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 71..86
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 835..853
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 897..992
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 992 AA; 110138 MW; D4B4D12067BFD8F0 CRC64;
MARKEATKKE EAMPLLKDVK KGDVKEEKKA ARDDGGEAKR GKAAAAGQKT KAPAAKDERK
DAVGQKPDTP AAFTAPSQST QSMSPEVKEL YPPDQIKVVS LNDIMDVSNS QSISKTQYVQ
NDEGKRVAIK EPSEPQKAVL DQQLFDKHYG YRRVDLTLGR KVHWHFKQVL KWRKVDWAHF
FMGRVPITKW LPSYNWITDL RADVLGGVML SIMSLPQGLA YGYLVGVPPI YGLITATFGP
LVYTIFGSSR HNSPGCFAIA ALMVGGVVEQ FAHVDDVQAA IENTHQPNIC CKSASSVIEP
EAAIGVTSSI TFLVGLWQIF FGLLNAGLLA VWLSDHLVQG LTSGAAVHVF TSQLKAMTGV
DGVPPTSEPF GLIKFYLCFF RRLHTIKLPC IIISLVGNFL LLLSSYFIDP IIKKWTNLKF
PMELLLVSFS ILLVFLSEGT RYQINVPVVG KVESGFPSPQ VPSFNLVGEL VWHGISIAII
SFVIHIALAK LVSKKFHYEI DVNQEWFALG AMNTISSFFG CFVGGSSIGR TMTQVKFGTT
SQLSTMVCCF IMVGFVYGAG AFIYHLPKAV LACIILCAMK DLYIQLFRGF RLCRESTVDF
MIFFVTLVSV ILINVNTGLV IGIVFALLTV VFRTQWADST CMGRIPGTSD FKGLGHYRSA
EEIPGIKVFR FDAPLYFANA ELFILSVHNA CGLNPVLVKA KLIERAAAEK AKEAMDDSSE
ANKTSSRDMQ LRVVGRRLAD ASVDSVAEDP AEHVVTQLTH IIIDCSTIPY IDLMGKDAIA
QTFADYATID ITVLIANCKV AVRQLFETTD FYQKVPKNRM FVSVNDAVTQ ALKEQRERVP
ERKQIDHTGG QRHIAKDPVA LSPAQKTVIL NVLNEEGEEQ LTQSAASATL STQRADVSTE
IKKDSAQIRK GLQKFEKKKE DKAKKDDKKK EESATKKEEK KKEEGKRVDK AKKDDKKKEE
SAKKEEKKKE EGKRLRWRRF SKASKKDVDK TQ
//
