ID   A0A016VAS7_9BILA        Unreviewed;       960 AA.
AC   A0A016VAS7;
DT   11-JUN-2014, integrated into UniProtKB/TrEMBL.
DT   11-JUN-2014, sequence version 1.
DT   27-MAR-2024, entry version 22.
DE   RecName: Full=Reverse transcriptase domain-containing protein {ECO:0000259|PROSITE:PS50878};
GN   Name=Acey_s0013.g1943 {ECO:0000313|EMBL:EYC24520.1};
GN   ORFNames=Y032_0013g1943 {ECO:0000313|EMBL:EYC24520.1};
OS   Ancylostoma ceylanicum.
OC   Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC   Rhabditina; Rhabditomorpha; Strongyloidea; Ancylostomatidae;
OC   Ancylostomatinae; Ancylostoma.
OX   NCBI_TaxID=53326 {ECO:0000313|EMBL:EYC24520.1, ECO:0000313|Proteomes:UP000024635};
RN   [1] {ECO:0000313|Proteomes:UP000024635}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=HY135 {ECO:0000313|Proteomes:UP000024635};
RX   PubMed=25730766; DOI=10.1038/ng.3237;
RA   Schwarz E.M., Hu Y., Antoshechkin I., Miller M.M., Sternberg P.W.,
RA   Aroian R.V.;
RT   "The genome and transcriptome of the zoonotic hookworm Ancylostoma
RT   ceylanicum identify infection-specific gene families.";
RL   Nat. Genet. 47:416-422(2015).
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:EYC24520.1}.
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DR   EMBL; JARK01001349; EYC24520.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A016VAS7; -.
DR   STRING; 53326.A0A016VAS7; -.
DR   Proteomes; UP000024635; Unassembled WGS sequence.
DR   GO; GO:0003824; F:catalytic activity; IEA:InterPro.
DR   CDD; cd09076; L1-EN; 1.
DR   CDD; cd01650; RT_nLTR_like; 1.
DR   Gene3D; 3.60.10.10; Endonuclease/exonuclease/phosphatase; 1.
DR   InterPro; IPR043502; DNA/RNA_pol_sf.
DR   InterPro; IPR036691; Endo/exonu/phosph_ase_sf.
DR   InterPro; IPR005135; Endo/exonuclease/phosphatase.
DR   InterPro; IPR000477; RT_dom.
DR   PANTHER; PTHR47027; REVERSE TRANSCRIPTASE DOMAIN-CONTAINING PROTEIN; 1.
DR   PANTHER; PTHR47027:SF8; REVERSE TRANSCRIPTASE DOMAIN-CONTAINING PROTEIN; 1.
DR   Pfam; PF03372; Exo_endo_phos; 1.
DR   Pfam; PF00078; RVT_1; 1.
DR   SUPFAM; SSF56672; DNA/RNA polymerases; 1.
DR   SUPFAM; SSF56219; DNase I-like; 1.
DR   PROSITE; PS50878; RT_POL; 1.
PE   4: Predicted;
KW   Reference proteome {ECO:0000313|Proteomes:UP000024635}.
FT   DOMAIN          492..751
FT                   /note="Reverse transcriptase"
FT                   /evidence="ECO:0000259|PROSITE:PS50878"
SQ   SEQUENCE   960 AA;  109960 MW;  ED3901761DD78C64 CRC64;
     MASADRMPKH STDFFQIATV NVRSIATPER LAEFETSVEK IKFDIIGLSE TRMSGAGRTD
     LRSGYSLYYS GSDGRTSRGV GFYVPSSLNR NIKCYFHSER IIELVLTKSP RTCLRIIQVH
     APHSDYEDSD YEDFLDDLAT IIDSRGNKHL VVLGDFNASV GSARANERYI GPNAAESRNH
     RGVMLAAFCE ERRLYLANTF FQKRKKSRWT WQNNALGLKK EIDYVIVQNM RGLTDVGVLV
     SINVGSDHRL VRCTLRLRST RRLVRPHRGT MSINDELLIS TTHELVNKMV LTGDVRKDYS
     SITNLINDAT ERASFYEPLP PRISQNTREL LRQRRQLRHG TDSRNVEYAE LCKLIRRSFK
     EDLYRRHVEI LQKAIQSCRI RLGQEELTYA RRSLPPIRNT PTCFHNSSAS HDPVSDAIKA
     VQTFYNNLYR SSYGCQKPPS GQIEVRFTPE EVGNVLRSCK TRPKPGADGV RSAVMRPISN
     ILAEPLCQFF NSMIKEKTVP EDLAFAHTVL LYKSGDPANI ANYRPISLLS TLYKVLTKLI
     TRRLEEYACR NAILPPEQAG FRRNFSTVDH IQTITTLLEK SYEFNVSIYF MFIDFKKAFD
     SVELPALWDA MESFGFDQGL IKLAQLLYAN GRAAARIGDD WAEFQVERGV RQGDSLSPLL
     FNVVLQYGLN NVPWQGRGLR LNGRLLSYLA YADDVVLIAN NVTELTEMAT ALSDSASSIG
     LEINFAKTKW LHNQRGSRNS EEQIVLCGEI IEKVEEFIYL GQLISCPRNP MKEIRRRIHM
     GRAVYFKYRT FLRAPRVAIQ LKRKLVNHCI LPAVLYGCET WIWTKQVAAC LRSAERRLER
     AIIRVRLGDK VNSRSIRQRT GLKDWIHSAL RRKWKYAAKL SKKSPDESWT RVATDWTPEG
     KRSTGRPKMR WIDELAKFKG CPGKDLACDW TKLFDGDVKK SAELFARKAR YSLCRCDKRV
//