ID A0A016VHG7_9BILA Unreviewed; 856 AA.
AC A0A016VHG7;
DT 11-JUN-2014, integrated into UniProtKB/TrEMBL.
DT 11-JUN-2014, sequence version 1.
DT 27-MAR-2024, entry version 34.
DE RecName: Full=Sec7 domain protein {ECO:0008006|Google:ProtNLM};
GN Name=Acey_s0010.g940 {ECO:0000313|EMBL:EYC26741.1};
GN Synonyms=Acey-efa-6 {ECO:0000313|EMBL:EYC26741.1};
GN ORFNames=Y032_0010g940 {ECO:0000313|EMBL:EYC26741.1};
OS Ancylostoma ceylanicum.
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Rhabditina; Rhabditomorpha; Strongyloidea; Ancylostomatidae;
OC Ancylostomatinae; Ancylostoma.
OX NCBI_TaxID=53326 {ECO:0000313|EMBL:EYC26741.1, ECO:0000313|Proteomes:UP000024635};
RN [1] {ECO:0000313|Proteomes:UP000024635}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=HY135 {ECO:0000313|Proteomes:UP000024635};
RX PubMed=25730766; DOI=10.1038/ng.3237;
RA Schwarz E.M., Hu Y., Antoshechkin I., Miller M.M., Sternberg P.W.,
RA Aroian R.V.;
RT "The genome and transcriptome of the zoonotic hookworm Ancylostoma
RT ceylanicum identify infection-specific gene families.";
RL Nat. Genet. 47:416-422(2015).
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:EYC26741.1}.
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DR EMBL; JARK01001346; EYC26741.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A016VHG7; -.
DR STRING; 53326.A0A016VHG7; -.
DR Proteomes; UP000024635; Unassembled WGS sequence.
DR GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:InterPro.
DR GO; GO:0032012; P:regulation of ARF protein signal transduction; IEA:InterPro.
DR CDD; cd13295; PH_EFA6; 1.
DR CDD; cd00171; Sec7; 1.
DR Gene3D; 1.10.1000.11; Arf Nucleotide-binding Site Opener,domain 2; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR041681; PH_9.
DR InterPro; IPR001849; PH_domain.
DR InterPro; IPR023394; Sec7_C_sf.
DR InterPro; IPR000904; Sec7_dom.
DR InterPro; IPR035999; Sec7_dom_sf.
DR PANTHER; PTHR10663; GUANYL-NUCLEOTIDE EXCHANGE FACTOR; 1.
DR PANTHER; PTHR10663:SF376; PH AND SEC7 DOMAIN-CONTAINING PROTEIN; 1.
DR Pfam; PF15410; PH_9; 1.
DR Pfam; PF01369; Sec7; 1.
DR SMART; SM00233; PH; 1.
DR SMART; SM00222; Sec7; 1.
DR SUPFAM; SSF50729; PH domain-like; 1.
DR SUPFAM; SSF48425; Sec7 domain; 1.
DR PROSITE; PS50003; PH_DOMAIN; 1.
DR PROSITE; PS50190; SEC7; 1.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000024635}.
FT DOMAIN 278..444
FT /note="SEC7"
FT /evidence="ECO:0000259|PROSITE:PS50190"
FT DOMAIN 481..593
FT /note="PH"
FT /evidence="ECO:0000259|PROSITE:PS50003"
FT REGION 1..43
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 77..196
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 212..235
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 11..36
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 101..123
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 153..170
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 182..196
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 856 AA; 95508 MW; 5E1EA8FA4462C0C8 CRC64;
MAAVAQSGAR EAMSTYPSSP VASPCDSSSL ARGDSPSATR SPRCEAFVMT GDKILNLNHH
ISPNYAKVAR DQLPPSTQIL ETPKPRPPPT LSDFPSVRRS MRSRIPTSRS QPEAVSTQRQ
VSCPEPVPER CSPADLSSGS PSLALPPPSI DEKPQTATVS SPVTSEKSPE TDLRTASDFA
SIDEDPPSSA TTAQAMESSM HSSYYKSAFS NPQISHKKTG SSDTFVISSG DSPTKHSTVT
VNAINCAPSV STTTSPSQRR LMSTRRQHTG NTEVFGSFRS DDTIGADSQC PVEEEREAAK
EAAKLFRLEG CTKADVAERL NDRSEFSALV TTKYLEMFVF SSLRIDAALR EFLSRVELRG
DSSERERLLR FFSTRYHQCD PSLFDSVDDV HTLTCALLLL NSDLHGQNLG KKMTIRDFIN
NISHTGVHYK RDLLKALYNS IKENEIVHAS KFEKPTATKI ASKRSFVSRQ LLLEVDPDSQ
VEYKCGYIMR KCVYDADGAK TPFGRRGWRE WYARLRGLVL YLGRDDSEKK RSRYETFNNA
ILLHHAFAEP APDYKKKQYI FRVRTANLGE FLFQTTSASE VEDWVTQINF ACARFSSRAL
PPPACSGGAF SRARLPKLPS SAPLAQQLKA HESAACELRE QLNRVRQEAP PLKAKGRPVE
EFFFKERYLT QEILRYDTYC HLLRSRLPGG GCELGGAPSD STSGVHSKSD IADDLDKMSY
REAKEKSPRA PRYQRKTSRE RECVHVCEFM LTRTLFLAVA GAAVLFVEAN IRSDPIIILD
CDPLGTLWRM GSNHHCVCRP YFYGEFCHRI RRCVSGRPVT VNCTNPEERY APHAERRCTS
NLKSSIDVSQ VAVFEM
//
