ID   A0A016VIT4_9BILA        Unreviewed;       146 AA.
AC   A0A016VIT4;
DT   11-JUN-2014, integrated into UniProtKB/TrEMBL.
DT   11-JUN-2014, sequence version 1.
DT   27-MAR-2024, entry version 39.
DE   SubName: Full=Uncharacterized protein {ECO:0000313|EMBL:EYC27196.1};
GN   Name=Acey_s0009.g570 {ECO:0000313|EMBL:EYC27196.1};
GN   ORFNames=Y032_0009g570 {ECO:0000313|EMBL:EYC27196.1};
OS   Ancylostoma ceylanicum.
OC   Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC   Rhabditina; Rhabditomorpha; Strongyloidea; Ancylostomatidae;
OC   Ancylostomatinae; Ancylostoma.
OX   NCBI_TaxID=53326 {ECO:0000313|EMBL:EYC27196.1, ECO:0000313|Proteomes:UP000024635};
RN   [1] {ECO:0000313|Proteomes:UP000024635}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=HY135 {ECO:0000313|Proteomes:UP000024635};
RX   PubMed=25730766; DOI=10.1038/ng.3237;
RA   Schwarz E.M., Hu Y., Antoshechkin I., Miller M.M., Sternberg P.W.,
RA   Aroian R.V.;
RT   "The genome and transcriptome of the zoonotic hookworm Ancylostoma
RT   ceylanicum identify infection-specific gene families.";
RL   Nat. Genet. 47:416-422(2015).
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:EYC27196.1}.
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DR   EMBL; JARK01001345; EYC27196.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A016VIT4; -.
DR   STRING; 53326.A0A016VIT4; -.
DR   Proteomes; UP000024635; Unassembled WGS sequence.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0008191; F:metalloendopeptidase inhibitor activity; IEA:InterPro.
DR   CDD; cd03577; NTR_TIMP_like; 1.
DR   Gene3D; 2.40.50.120; -; 1.
DR   InterPro; IPR001134; Netrin_domain.
DR   InterPro; IPR001820; TIMP.
DR   InterPro; IPR008993; TIMP-like_OB-fold.
DR   PANTHER; PTHR11844; METALLOPROTEASE INHIBITOR; 1.
DR   PANTHER; PTHR11844:SF33; TISSUE INHIBITOR OF METALLOPROTEINASE; 1.
DR   Pfam; PF00965; TIMP; 1.
DR   SMART; SM00206; NTR; 1.
DR   SUPFAM; SSF50242; TIMP-like; 1.
DR   PROSITE; PS50189; NTR; 1.
PE   4: Predicted;
KW   Disulfide bond {ECO:0000256|ARBA:ARBA00023157,
KW   ECO:0000256|PIRSR:PIRSR601820-3};
KW   Metal-binding {ECO:0000256|PIRSR:PIRSR601820-1};
KW   Reference proteome {ECO:0000313|Proteomes:UP000024635};
KW   Zinc {ECO:0000256|PIRSR:PIRSR601820-1}.
FT   BINDING         20
FT                   /ligand="Zn(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29105"
FT                   /ligand_note="ligand shared with metalloproteinase partner"
FT                   /evidence="ECO:0000256|PIRSR:PIRSR601820-1"
FT   DISULFID        20..89
FT                   /evidence="ECO:0000256|PIRSR:PIRSR601820-3"
FT   DISULFID        22..116
FT                   /evidence="ECO:0000256|PIRSR:PIRSR601820-3"
SQ   SEQUENCE   146 AA;  16436 MW;  E0AB37841A0FD619 CRC64;
     MQMMLFMTVF FACTVVAHGC SCLEAPLEEM YCRSEYVTRV IVKGEDRSRE AGPIGFIVYN
     VEHMKIYKKP GNVQELSTNV TTRGPQSYCG APLEVGYDFL IGGSLSWNGM LDHSLCDLRE
     HWDLLSPDEK DRLMCKAFKC GTEACS
//