ID A0A016VLC1_9BILA Unreviewed; 1799 AA.
AC A0A016VLC1;
DT 11-JUN-2014, integrated into UniProtKB/TrEMBL.
DT 11-JUN-2014, sequence version 1.
DT 27-MAR-2024, entry version 38.
DE RecName: Full=Ion transport domain-containing protein {ECO:0000259|Pfam:PF00520};
GN Name=Acey_s0008.g206 {ECO:0000313|EMBL:EYC27832.1};
GN ORFNames=Y032_0008g206 {ECO:0000313|EMBL:EYC27832.1};
OS Ancylostoma ceylanicum.
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Rhabditina; Rhabditomorpha; Strongyloidea; Ancylostomatidae;
OC Ancylostomatinae; Ancylostoma.
OX NCBI_TaxID=53326 {ECO:0000313|EMBL:EYC27832.1, ECO:0000313|Proteomes:UP000024635};
RN [1] {ECO:0000313|Proteomes:UP000024635}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=HY135 {ECO:0000313|Proteomes:UP000024635};
RX PubMed=25730766; DOI=10.1038/ng.3237;
RA Schwarz E.M., Hu Y., Antoshechkin I., Miller M.M., Sternberg P.W.,
RA Aroian R.V.;
RT "The genome and transcriptome of the zoonotic hookworm Ancylostoma
RT ceylanicum identify infection-specific gene families.";
RL Nat. Genet. 47:416-422(2015).
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:EYC27832.1}.
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DR EMBL; JARK01001344; EYC27832.1; -; Genomic_DNA.
DR STRING; 53326.A0A016VLC1; -.
DR Proteomes; UP000024635; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0005261; F:monoatomic cation channel activity; IEA:InterPro.
DR Gene3D; 1.10.287.70; -; 4.
DR Gene3D; 1.10.238.10; EF-hand; 1.
DR Gene3D; 1.20.120.350; Voltage-gated potassium channels. Chain C; 3.
DR InterPro; IPR005821; Ion_trans_dom.
DR InterPro; IPR028823; NALCN.
DR InterPro; IPR027359; Volt_channel_dom_sf.
DR PANTHER; PTHR46141:SF1; SODIUM LEAK CHANNEL NALCN; 1.
DR PANTHER; PTHR46141; SODIUM LEAK CHANNEL NON-SELECTIVE PROTEIN; 1.
DR Pfam; PF00520; Ion_trans; 4.
DR SUPFAM; SSF81324; Voltage-gated potassium channels; 4.
PE 4: Predicted;
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000024635};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 36..62
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 108..130
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 227..249
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 312..333
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 345..370
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 435..457
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 504..528
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 846..867
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 879..897
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 940..962
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1054..1080
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1205..1225
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1237..1257
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1277..1297
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1309..1326
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1347..1371
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1432..1458
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 20..258
FT /note="Ion transport"
FT /evidence="ECO:0000259|Pfam:PF00520"
FT DOMAIN 311..535
FT /note="Ion transport"
FT /evidence="ECO:0000259|Pfam:PF00520"
FT DOMAIN 804..1084
FT /note="Ion transport"
FT /evidence="ECO:0000259|Pfam:PF00520"
FT DOMAIN 1211..1469
FT /note="Ion transport"
FT /evidence="ECO:0000259|Pfam:PF00520"
FT REGION 669..721
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1632..1675
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1734..1756
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 669..689
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 694..721
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1632..1651
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1652..1675
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1799 AA; 207941 MW; B5B5FBC75A2EB433 CRC64;
MRMPIFTLST IRKRGNGKGF GNESSYLRAR WSQFDLFMLL MHVLSCALHC YELFTILVPS
LGLVYRPWFG VIRSPRPFIM LRFIRSLVRF KLPKNRIKQI IKRSSQQIQN VTIFFMFFMA
LYAIMGVQLF GRMDYHCVLS GTDPRNVTIA DLAIPDTMCS QKGEGGYECP DNMVCMKLDM
SAHVEGFYGM FNDFASSLFT VYMAASQEGW VYVLYDCLDT LPSYVAFFYF VTLIFFLAWL
VKNVFIAVIT ETFAEIRVQF SEMWQSNTSA SEDTYTQRLE RFEGGWRLVE IDHYSRGTNS
PQFLHLLVNS TAFQITMMVL VLLNALINAS FVYRHDNSDI VRKEIYYYVE ICFTIVFNLE
ALIKVIGYGW KGYLRRGQHK FELILCVGST LNLIRPLYNM NIFTYFQVFR IVRLIKASPM
LEDFVYKIFG PGKKLGGLVV FTMVLLFITS AISLQLFCYV PNLKKFTTFP MAFMSMFQII
TQEGWTDVVV EILRATNESM VPFVAIYFVG YHLLVTLIVL SLFVAVILDN LEMDEELKKV
KQLKAREQNT IKTTLPWRLR VFDRFPTRPQ MISLKKVTSE FPLPKIRDSF TRQFADENER
NNADSNEAEN ANTRSILRRG ANIRAQRKIR LRHIGQNSSR HILTSLLEES NRHRALYCDS
NQFIPNLGRG NLKNTKGTPM GSRTRGFQSM KGKNHIEGLK ENGDVRPSDS APKKEPKQGE
IDIKALQQKR AHAEITRNRI EEEMRENHPL FDRPLFAVGR DSRLRVLCQN IVYAQYSPER
IDPVTGKQII LKYKQLHDFI GLMTYLDWAM VLVTSLSCWS MLFESPWPLN GENLIFNNPL
LQITEYLYVV TMTFELMVKV IANGLFFTPK AVVKDVGDIM TFFIYFTSLI YLLWMPSHVE
INSWAQLLMI MRAMRPLRIY TLVPHIRRVV VELCRGFKEI LLVTILLIVL MFMFASFGVQ
IVGGKLAACN DPTITERVNC TGVFEQKIFV TRMEVYGKND DKLHPKILVP RVWTNPRNFN
FDHIGNAMLA LFETLSYKGW NVIRDILYLR QGPWAVLFIH IYVFIGCMIG LTLFVGVVVA
NYTENRGTAL LTVDQRRWHD LKARLKMAQP LHVPPKPPES AKLRSYLYDL TLSRGFKQVS
HAPFGKNDGF PFRDILPASC ELFFHLLAEA DAENGCEKEA PRKNGGLHRP GDPDGKKAYK
KVTACSVQSF AILVVINSCT LVVPWNVEEE KQRRNVLFGL TILSAFCNIL FTIEIILKSV
AFTVRGFWQS RRNRGDFVIT ILGLTWIVFH FLFQVPAYIA GGINEWKRLT YTFGYMVVIL
RFFTIAGRKS TLKMLMLTVL MSMVRSLFII AAMFLLVLFY AYTGVILFGM VKYGQAVSKH
VNFRNGREAL VVLFRSVTGE DWNDIMHDCM RSPPFCYWAE GLNYWETDCG NYFGAIVYFC
SFYLIITYIV LNLLVAIIME NFSLFYSSEE DALLSYADIR NFQQVWNIVD ADQKRSIPTR
RVKFLLRLLR GRLEVDPNKD RLLFKHMCYE MERLHNGEDV SFHDVLNMLS YRSVDIRKSL
QLEELLQREE LEYLIEEEVA KQTIRAWLEQ CLRRIKQKQN VQTQPESIVP TSLALHRLSC
LIPLVPHVPS QHNLQTAHAT PPTTTQNFDS FESRESIEED GGSRRKQRRR NSIPELVGEA
KKFMFGSLAK RLEKAAESKS GKDRRGTLKQ LQMPTYELPD LEENLDEACD SPQERRHSVD
TPMSNNPGRT VKFPELPRGT YSASGIDLLV LNASSPSVEF PNIEPNPDLH QWWTDLFEL
//
