ID A0A016VLU7_9BILA Unreviewed; 625 AA.
AC A0A016VLU7;
DT 11-JUN-2014, integrated into UniProtKB/TrEMBL.
DT 11-JUN-2014, sequence version 1.
DT 27-MAR-2024, entry version 23.
DE RecName: Full=Nicastrin {ECO:0000256|ARBA:ARBA00015303};
GN Name=Acey_s0008.g76 {ECO:0000313|EMBL:EYC28286.1};
GN ORFNames=Y032_0008g76 {ECO:0000313|EMBL:EYC28286.1};
OS Ancylostoma ceylanicum.
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Rhabditina; Rhabditomorpha; Strongyloidea; Ancylostomatidae;
OC Ancylostomatinae; Ancylostoma.
OX NCBI_TaxID=53326 {ECO:0000313|EMBL:EYC28286.1, ECO:0000313|Proteomes:UP000024635};
RN [1] {ECO:0000313|Proteomes:UP000024635}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=HY135 {ECO:0000313|Proteomes:UP000024635};
RX PubMed=25730766; DOI=10.1038/ng.3237;
RA Schwarz E.M., Hu Y., Antoshechkin I., Miller M.M., Sternberg P.W.,
RA Aroian R.V.;
RT "The genome and transcriptome of the zoonotic hookworm Ancylostoma
RT ceylanicum identify infection-specific gene families.";
RL Nat. Genet. 47:416-422(2015).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004479}; Single-
CC pass type I membrane protein {ECO:0000256|ARBA:ARBA00004479}.
CC -!- SIMILARITY: Belongs to the nicastrin family.
CC {ECO:0000256|ARBA:ARBA00007717}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:EYC28286.1}.
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DR EMBL; JARK01001344; EYC28286.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A016VLU7; -.
DR STRING; 53326.A0A016VLU7; -.
DR Proteomes; UP000024635; Unassembled WGS sequence.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProt.
DR GO; GO:0007219; P:Notch signaling pathway; IEA:UniProtKB-KW.
DR GO; GO:0016485; P:protein processing; IEA:InterPro.
DR Gene3D; 3.40.630.10; Zn peptidases; 1.
DR InterPro; IPR041084; Ncstrn_small.
DR InterPro; IPR008710; Nicastrin.
DR PANTHER; PTHR21092; NICASTRIN; 1.
DR PANTHER; PTHR21092:SF0; NICASTRIN; 1.
DR Pfam; PF18266; Ncstrn_small; 1.
DR Pfam; PF05450; Nicastrin; 1.
DR SUPFAM; SSF53187; Zn-dependent exopeptidases; 1.
PE 3: Inferred from homology;
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Notch signaling pathway {ECO:0000256|ARBA:ARBA00022976};
KW Reference proteome {ECO:0000313|Proteomes:UP000024635};
KW Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|SAM:SignalP};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT SIGNAL 1..18
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 19..625
FT /note="Nicastrin"
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5001493691"
FT TRANSMEM 586..603
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 43..129
FT /note="Nicastrin small lobe"
FT /evidence="ECO:0000259|Pfam:PF18266"
SQ SEQUENCE 625 AA; 69258 MW; D9F13896D7AEF27F CRC64;
MLLIGSMFVP IVLWRLNAVR EYQSPGLSSD YDTTHAIPPI HITFPPASST LICIYEDGCT
STSLWNEKGY VLPDGLRNID WNMQILYLFN KTHIDAIKKC HDLFNVPKDG APFVSFPFCA
ASFGVFSTAA GSSEICYRRS KPWSRLFDVS IENKDDLCSP LVGVSIMAYL PPKVYNATAT
PHTAKYLMLC TRIDSFGIIP EISPGEISVL TSVIALLATT RSIGQHLDVF ERAANTSGRH
VIVAFFDGES FDYIGSSDAA YDMMNDEFPR KLRMDLKAQL DPVIASQLDS IVEVQQLGTG
DGSASLYALA DGRQFEKGEL KHLLKALTAG ATAAGGSLNA PTAKSRVPPA SWHSFARHEP
SIRGVVLAPF RDEYNYRRVN SILDRAQWTS AQRSAAITEV LVAASAMLRA AADHVGLDTA
QQMALDIDKD FVTSLFECFI DEPDWFKCDF FNKLNGGRFK ASTAFYSGKS SYVSAGYRNP
VRFFVEWLTT YAAGSTSYTS NVKDEKTCDD LGKDQNVYVY TWQADPRSGA YYCYRTSMGA
YTVSSPAFRI EGYDFSNGTY STWTESLYSI DNLRLYLVEQ ESFEKVMLGL GIVIAIVSFL
VVGRCNEESF IIDEGERLAE EGEPL
//
