ID A0A016VLV7_9BILA Unreviewed; 568 AA.
AC A0A016VLV7;
DT 11-JUN-2014, integrated into UniProtKB/TrEMBL.
DT 11-JUN-2014, sequence version 1.
DT 27-MAR-2024, entry version 34.
DE RecName: Full=Laminin EGF-like protein {ECO:0008006|Google:ProtNLM};
GN Name=Acey_s0008.g79 {ECO:0000313|EMBL:EYC28296.1};
GN Synonyms=Acey-agr-1 {ECO:0000313|EMBL:EYC28296.1};
GN ORFNames=Y032_0008g79 {ECO:0000313|EMBL:EYC28296.1};
OS Ancylostoma ceylanicum.
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Rhabditina; Rhabditomorpha; Strongyloidea; Ancylostomatidae;
OC Ancylostomatinae; Ancylostoma.
OX NCBI_TaxID=53326 {ECO:0000313|EMBL:EYC28296.1, ECO:0000313|Proteomes:UP000024635};
RN [1] {ECO:0000313|Proteomes:UP000024635}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=HY135 {ECO:0000313|Proteomes:UP000024635};
RX PubMed=25730766; DOI=10.1038/ng.3237;
RA Schwarz E.M., Hu Y., Antoshechkin I., Miller M.M., Sternberg P.W.,
RA Aroian R.V.;
RT "The genome and transcriptome of the zoonotic hookworm Ancylostoma
RT ceylanicum identify infection-specific gene families.";
RL Nat. Genet. 47:416-422(2015).
CC -!- SUBCELLULAR LOCATION: Secreted, extracellular space, extracellular
CC matrix, basement membrane {ECO:0000256|ARBA:ARBA00004302}.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00460}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:EYC28296.1}.
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DR EMBL; JARK01001344; EYC28296.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A016VLV7; -.
DR Proteomes; UP000024635; Unassembled WGS sequence.
DR CDD; cd00055; EGF_Lam; 2.
DR CDD; cd00104; KAZAL_FS; 1.
DR CDD; cd00110; LamG; 1.
DR Gene3D; 2.60.120.200; -; 2.
DR Gene3D; 3.30.60.30; -; 1.
DR Gene3D; 2.10.25.10; Laminin; 2.
DR InterPro; IPR013320; ConA-like_dom_sf.
DR InterPro; IPR002350; Kazal_dom.
DR InterPro; IPR036058; Kazal_dom_sf.
DR InterPro; IPR001791; Laminin_G.
DR InterPro; IPR002049; LE_dom.
DR PANTHER; PTHR10574:SF365; NETRIN-A-RELATED; 1.
DR PANTHER; PTHR10574; NETRIN/LAMININ-RELATED; 1.
DR Pfam; PF07648; Kazal_2; 1.
DR Pfam; PF00053; Laminin_EGF; 2.
DR Pfam; PF02210; Laminin_G_2; 1.
DR SMART; SM00180; EGF_Lam; 2.
DR SMART; SM00280; KAZAL; 1.
DR SMART; SM00282; LamG; 2.
DR SUPFAM; SSF49899; Concanavalin A-like lectins/glucanases; 2.
DR SUPFAM; SSF57196; EGF/Laminin; 1.
DR SUPFAM; SSF100895; Kazal-type serine protease inhibitors; 1.
DR PROSITE; PS01248; EGF_LAM_1; 2.
DR PROSITE; PS50027; EGF_LAM_2; 2.
DR PROSITE; PS51465; KAZAL_2; 1.
DR PROSITE; PS50025; LAM_G_DOMAIN; 1.
PE 4: Predicted;
KW Basement membrane {ECO:0000256|ARBA:ARBA00022869};
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157, ECO:0000256|PROSITE-
KW ProRule:PRU00460}; Extracellular matrix {ECO:0000256|ARBA:ARBA00022530};
KW Laminin EGF-like domain {ECO:0000256|ARBA:ARBA00023292,
KW ECO:0000256|PROSITE-ProRule:PRU00460};
KW Reference proteome {ECO:0000313|Proteomes:UP000024635};
KW Secreted {ECO:0000256|ARBA:ARBA00022530}.
FT DOMAIN 31..82
FT /note="Laminin EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50027"
FT DOMAIN 83..129
FT /note="Laminin EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50027"
FT DOMAIN 154..214
FT /note="Kazal-like"
FT /evidence="ECO:0000259|PROSITE:PS51465"
FT DOMAIN 401..568
FT /note="Laminin G"
FT /evidence="ECO:0000259|PROSITE:PS50025"
FT DISULFID 31..43
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00460"
FT DISULFID 51..60
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00460"
FT DISULFID 83..95
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00460"
FT DISULFID 85..102
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00460"
FT DISULFID 104..113
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00460"
SQ SEQUENCE 568 AA; 61836 MW; 2B6159BE5F5D95B4 CRC64;
MCISNETLDY NALLEYGNPK ELMLNALDYA CQCHSLGSFG PNCDKDGNCR CRAGVGGAKC
DHCLPGFWGL HLIATGAQSC KPCGCSSFGS SRADCEQSTG RCECSRGARG EKCERCASDF
VMTPSGCVAR QEFQAPRSCS FLKCHHGAKC VESNVGLPDC KCPEHCSVDH LGIVANMSVC
GSDGTTYEDM CQLLQFACKH QLDIVAVSLG ICPQDSAEPR ERNNRQRENS IEVDACLTGN
CSTSTENERS LDLVMDGKRA YKVTSEGDNV HMNVTLTVIP RSSNGMILFA KGDKTSFALR
CEMRRIVADF GRDVLYSSER LQLGSEQKIA LTWSGRTASL KVGGSVTSLA VANENEPLTE
LSIGQYRGQS LIGRIVQLSV NGRAVQRSDV ALCSGSRERY LSPVAFENGA YLELPQLDVG
VKSKLQLELS VRPLSKEGLL LLWSSSTTRR NNVTYVALVL HESRSHLFLD IGKETVSLFG
GPITTSSWTT IKFEVDPSNA SLYLNGSLAA SKSFRGGHFT LGNSTVFLGG THSGHSLPEE
LHKYVRPFSG ELRRLAINER PFDLHEVR
//
