ID A0A016VM14_9BILA Unreviewed; 997 AA.
AC A0A016VM14;
DT 11-JUN-2014, integrated into UniProtKB/TrEMBL.
DT 11-JUN-2014, sequence version 1.
DT 27-MAR-2024, entry version 25.
DE RecName: Full=Amino acid permease {ECO:0008006|Google:ProtNLM};
GN Name=Acey_s0008.g197 {ECO:0000313|EMBL:EYC27813.1};
GN ORFNames=Y032_0008g197 {ECO:0000313|EMBL:EYC27813.1};
OS Ancylostoma ceylanicum.
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Rhabditina; Rhabditomorpha; Strongyloidea; Ancylostomatidae;
OC Ancylostomatinae; Ancylostoma.
OX NCBI_TaxID=53326 {ECO:0000313|EMBL:EYC27813.1, ECO:0000313|Proteomes:UP000024635};
RN [1] {ECO:0000313|Proteomes:UP000024635}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=HY135 {ECO:0000313|Proteomes:UP000024635};
RX PubMed=25730766; DOI=10.1038/ng.3237;
RA Schwarz E.M., Hu Y., Antoshechkin I., Miller M.M., Sternberg P.W.,
RA Aroian R.V.;
RT "The genome and transcriptome of the zoonotic hookworm Ancylostoma
RT ceylanicum identify infection-specific gene families.";
RL Nat. Genet. 47:416-422(2015).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:EYC27813.1}.
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DR EMBL; JARK01001344; EYC27813.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A016VM14; -.
DR Proteomes; UP000024635; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0015377; F:chloride:monoatomic cation symporter activity; IEA:InterPro.
DR Gene3D; 1.20.1740.10; Amino acid/polyamine transporter I; 1.
DR InterPro; IPR004841; AA-permease/SLC12A_dom.
DR InterPro; IPR018491; SLC12_C.
DR InterPro; IPR004842; SLC12A_fam.
DR NCBIfam; TIGR00930; 2a30; 1.
DR PANTHER; PTHR11827:SF103; SODIUM CHLORIDE COTRANSPORTER 69, ISOFORM E; 1.
DR PANTHER; PTHR11827; SOLUTE CARRIER FAMILY 12, CATION COTRANSPORTERS; 1.
DR Pfam; PF00324; AA_permease; 1.
DR Pfam; PF03522; SLC12; 1.
PE 4: Predicted;
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000024635};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 21..40
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 46..73
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 94..118
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 138..160
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 167..186
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 218..236
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 248..270
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 319..343
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 375..396
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 402..420
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 441..471
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 20..513
FT /note="Amino acid permease/ SLC12A"
FT /evidence="ECO:0000259|Pfam:PF00324"
FT DOMAIN 522..997
FT /note="SLC12A transporter C-terminal"
FT /evidence="ECO:0000259|Pfam:PF03522"
FT REGION 676..717
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 690..717
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 997 AA; 110231 MW; 445D775C43235C95 CRC64;
MEKFAPPPTQ ARVKFGWIQG VFVRCLLNIF GVMLYLRISW VAGQAGIGLG SVIVLLASLV
TSITAISTCA ICTNGDVKGG GAYFLISRSL GPEFGGSIGL IFSVANAVGA AMYIVGFAET
VRDLLRESNL HIIDADMWDV RIVGFATCVI LMGIVFIGTA FESKMQIGLL VILVASIIDY
MVGSVFPPNE GMIVRGATGY KMDTMLMNLW PSFRGEDFFS VFAVYFPAAT GIMAGANISG
DLADPQRAIP IGTLLAIGVT TVIYLATVWM TGSTCVRDAD GLSAPMWNNS IFVPPDCAAN
KTCPYGLMNY YQIMEMESLW GPLIVAGIFA ATLSSALASL VSAPKVFQAV CKDRLFPKIG
YFAKAYGKNE EPRRAYALTF IIAMAMIAIG DLNAIAPIIS NFFLASYALI NYACFDASFA
DSPGFRPGFK YYNMWVSLAG ALLCIVVMFI ISWATALITF FCFAALFLYI LHRKPDVNWG
SSTQAHSYKS ALSGMIKLAN TEEHVKNYRP QLLVLCGNAA ARPSLVDFAN SITKGTSLMM
CGYVVPYNPS DRVYSVMRKL ERQLSEWLRK RRVKAFYAAV ANPSLRAGAQ SLIQVCGLGK
LRPNIILIGF KTNWYHRGPT PETMEDMNEY FGTIQDAFDS NMAVCVLRNG EMGLDFSEAM
KLLNVGESKR LDINLDKEGL ESPSRPSAEN TESSKEDQKN EAEEEKAETG SLRHKDSARS
MERFAKLNHH YIAASNTLAE NYGFDDIEDE NCDCAPDQNE ECDKCKSEAK DRDDVELGNS
QPHLSDDAKG IKHTFSLRRR RFLNKVKKIS QDSTAAYVFC RTKRVVVVLF CVLLTRRPTT
EQKALLASIS RFQRKIKKGV IDVWWLYDDG GLTLLIPHLL TIPKSYLEGA KLRVFTISTS
SRTMEQEQRS MAALLSKFRI SFSDVSVISD IGRKPQPETL MRWEKLILPF IAADDSECPA
GMTTQSELDA QKQKTNRQLR AAELLREHSI DADLIVM
//
