ID A0A016VPA3_9BILA Unreviewed; 513 AA.
AC A0A016VPA3;
DT 11-JUN-2014, integrated into UniProtKB/TrEMBL.
DT 11-JUN-2014, sequence version 1.
DT 27-MAR-2024, entry version 23.
DE RecName: Full=Major facilitator superfamily (MFS) profile domain-containing protein {ECO:0008006|Google:ProtNLM};
GN Name=Acey_s0006.g2809 {ECO:0000313|EMBL:EYC29141.1};
GN ORFNames=Y032_0006g2809 {ECO:0000313|EMBL:EYC29141.1};
OS Ancylostoma ceylanicum.
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Rhabditina; Rhabditomorpha; Strongyloidea; Ancylostomatidae;
OC Ancylostomatinae; Ancylostoma.
OX NCBI_TaxID=53326 {ECO:0000313|EMBL:EYC29141.1, ECO:0000313|Proteomes:UP000024635};
RN [1] {ECO:0000313|Proteomes:UP000024635}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=HY135 {ECO:0000313|Proteomes:UP000024635};
RX PubMed=25730766; DOI=10.1038/ng.3237;
RA Schwarz E.M., Hu Y., Antoshechkin I., Miller M.M., Sternberg P.W.,
RA Aroian R.V.;
RT "The genome and transcriptome of the zoonotic hookworm Ancylostoma
RT ceylanicum identify infection-specific gene families.";
RL Nat. Genet. 47:416-422(2015).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the unc-93 family.
CC {ECO:0000256|ARBA:ARBA00009172}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:EYC29141.1}.
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DR EMBL; JARK01001342; EYC29141.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A016VPA3; -.
DR STRING; 53326.A0A016VPA3; -.
DR Proteomes; UP000024635; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR Gene3D; 1.20.1250.20; MFS general substrate transporter like domains; 1.
DR InterPro; IPR010291; Ion_channel_UNC-93.
DR InterPro; IPR036259; MFS_trans_sf.
DR PANTHER; PTHR23294; ET TRANSLATION PRODUCT-RELATED; 1.
DR PANTHER; PTHR23294:SF12; PROTEIN CBG22453; 1.
DR Pfam; PF05978; UNC-93; 1.
DR SUPFAM; SSF103473; MFS general substrate transporter; 1.
PE 3: Inferred from homology;
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000024635};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 93..114
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 121..139
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 145..169
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 181..206
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 235..253
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 295..316
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 328..348
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 360..379
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 399..416
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 462..481
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT REGION 494..513
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 513 AA; 57562 MW; A5C5F620A37B3989 CRC64;
MNFVHTSMFH RNEYKVSTTK FSQKDKPLRS CLYFFQAYPI MATSKFETLC IILLGLGQMC
IMTGYDSQSF VQESVIYSIS DRHPTLINHL AGYYGQAVIY ASFMITCIFA PALVFAITSK
WALFLSAVCF TIFETVYLYL NNYTYYTACL IVGFGLGIYY TAGGAYLASH STRRTIEKNS
AYSWSLMCLC LFIGSVILAI IIGYYAGKQQ HTNFVDNLSV NPKHRTFNDK EIRCMYAAFA
AISMGGTILF ALLPKRSVDD CIEDKRDMVT TSFTGRLGVT FETFTDKRML MLAPLFLYSG
LFTPFWVTVY PTSLLFTHTL DGSLYLPAFY SLAVGSGEVL MGTFVGAMSR RIKNFGLKPT
MYIGTTLSII ALAIITASVP KTATYEPTSE DAWLLRPSLP LAIATAILLG LVDSCMNNVK
TVMCALAMPG CRTHAFAVSR FYQGSSGTIV LFLSPYMSIY CYTALFGFTL LLTLFTFLRV
VKQILRTEKD SQRCGQSTKE KDVERDFKKE FEH
//
