ID A0A016VU24_9BILA Unreviewed; 1168 AA.
AC A0A016VU24;
DT 11-JUN-2014, integrated into UniProtKB/TrEMBL.
DT 11-JUN-2014, sequence version 1.
DT 27-MAR-2024, entry version 36.
DE RecName: Full=FH2 domain-containing protein {ECO:0008006|Google:ProtNLM};
GN Name=Acey_s0005.g2547 {ECO:0000313|EMBL:EYC30268.1};
GN Synonyms=Acey-cyk-1 {ECO:0000313|EMBL:EYC30268.1};
GN ORFNames=Y032_0005g2547 {ECO:0000313|EMBL:EYC30268.1};
OS Ancylostoma ceylanicum.
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Rhabditina; Rhabditomorpha; Strongyloidea; Ancylostomatidae;
OC Ancylostomatinae; Ancylostoma.
OX NCBI_TaxID=53326 {ECO:0000313|EMBL:EYC30268.1, ECO:0000313|Proteomes:UP000024635};
RN [1] {ECO:0000313|Proteomes:UP000024635}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=HY135 {ECO:0000313|Proteomes:UP000024635};
RX PubMed=25730766; DOI=10.1038/ng.3237;
RA Schwarz E.M., Hu Y., Antoshechkin I., Miller M.M., Sternberg P.W.,
RA Aroian R.V.;
RT "The genome and transcriptome of the zoonotic hookworm Ancylostoma
RT ceylanicum identify infection-specific gene families.";
RL Nat. Genet. 47:416-422(2015).
CC -!- SIMILARITY: Belongs to the formin homology family. Diaphanous
CC subfamily. {ECO:0000256|ARBA:ARBA00008214}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:EYC30268.1}.
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DR EMBL; JARK01001341; EYC30268.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A016VU24; -.
DR Proteomes; UP000024635; Unassembled WGS sequence.
DR GO; GO:0003779; F:actin binding; IEA:InterPro.
DR GO; GO:0031267; F:small GTPase binding; IEA:InterPro.
DR GO; GO:0030036; P:actin cytoskeleton organization; IEA:InterPro.
DR Gene3D; 1.20.58.630; -; 1.
DR Gene3D; 6.10.30.30; -; 1.
DR Gene3D; 1.20.58.2220; Formin, FH2 domain; 1.
DR Gene3D; 1.10.238.150; Formin, FH3 diaphanous domain; 1.
DR Gene3D; 1.25.10.10; Leucine-rich Repeat Variant; 1.
DR InterPro; IPR011989; ARM-like.
DR InterPro; IPR016024; ARM-type_fold.
DR InterPro; IPR015425; FH2_Formin.
DR InterPro; IPR042201; FH2_Formin_sf.
DR InterPro; IPR010472; FH3_dom.
DR InterPro; IPR014768; GBD/FH3_dom.
DR InterPro; IPR010473; GTPase-bd.
DR PANTHER; PTHR45691; PROTEIN DIAPHANOUS; 1.
DR PANTHER; PTHR45691:SF6; PROTEIN DIAPHANOUS; 1.
DR Pfam; PF06367; Drf_FH3; 1.
DR Pfam; PF06371; Drf_GBD; 1.
DR Pfam; PF02181; FH2; 1.
DR SMART; SM01139; Drf_FH3; 1.
DR SMART; SM01140; Drf_GBD; 1.
DR SMART; SM00498; FH2; 1.
DR SUPFAM; SSF48371; ARM repeat; 1.
DR SUPFAM; SSF101447; Formin homology 2 domain (FH2 domain); 1.
DR PROSITE; PS51444; FH2; 1.
DR PROSITE; PS51232; GBD_FH3; 1.
PE 3: Inferred from homology;
KW Coiled coil {ECO:0000256|ARBA:ARBA00023054, ECO:0000256|SAM:Coils};
KW Reference proteome {ECO:0000313|Proteomes:UP000024635}.
FT DOMAIN 73..483
FT /note="GBD/FH3"
FT /evidence="ECO:0000259|PROSITE:PS51232"
FT DOMAIN 666..1068
FT /note="FH2"
FT /evidence="ECO:0000259|PROSITE:PS51444"
FT REGION 566..671
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 718..740
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1057..1077
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 957..1011
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 589..661
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1168 AA; 131183 MW; 0E3750C83B4C4945 CRC64;
MRLDAASTWH PGVERTLAED FGLRRSPKES PTRWTDVFSS KRIRKKIHKH FGDSRVEDDR
NCTDEMVFAS QELRSLSSTE LNGRVEQVLK DRNIDQKTID QMLNNMGDER KRLILTQHIK
TDVSCTKKTP SMMIDQLIDV LDSESVLNRR KDITTLKVVL SGEGVRYLSE FAKNGNERSD
ENGLQLICRL FGVILEELRN AQEDTVESRE LLLILMEVVR CIRTIINTYP GLELVLERDS
RVVGRLIEGL CAINKRRAKE GEETEAARAL RAEIVKILAS LGMVNQESTK NIQMEMTGAQ
KMVKELTLLA AKNKQPRFKP ILDCLRFCKD SDVDHVYRIL IIVNLLIHSS DRELNEEQSW
QVRMALRSEL MRDGFGKYIP NIVVLSKTDE RIREVYSAYT SIQDDDFNEL VSRFETLRGE
YETLAGCYEL LASTTANTAV EPVLLSIMQH FMLIPEDVSV RLSYFHLIES CVNEIVLHKN
GVDPDFDSQF HFETPVSEII EQLQDAEFSR KLEQTVQAKQ EAVAKQMQYW QKLDEFRKEA
ALLRKHIANP SEPIPPATVC TLQQPVEQAV PSTSRLPPAE AGPATNGLPP ITGGPPPPPP
PPGARAAGGP PPPPPPPPPG FGGPPPPPPP PNLLRSGAGP PPPPPPGLGG PPRPPAEPAI
PDFLPAKKKR TVDVPMRKFP WTGSAINPRS LHRDCFWATT SEDSLANDSL LEQLKEKFST
SKPGPKGGDT LKTMKPAKKV KQPQIVKDEK ILQALAILQG SVKLSHKQWR KGLLKVDDSL
LSANTLQQLR TALPPLDVIK KLSEAEPSML EEMPEGEQFL ASLASIKALP LRLDLIIFKL
RFQEILNDLK PGISSVMEAC DEIRRSRGFK TFLELVLLFG NFMGQSSKTY KDTFAFEMNV
LTKLMDTKDV DNKFTLLHYM VDSMRKFDAK NARFAQEDFY HCIAASRVNG DELEKGVAAL
RQNVTKLDNC LKTYQKQCDD DAFIEVMAPF LAKAQAELDI TETMHNKMKS DWASFTKYYA
FDAKKYPMEQ FFTDMKTFKE QYEGVYRELE MERLRAEKES EESKSKKKRA TAAAKSQPAR
VGLAASRLQT AVDSPGVLDE LDKMMAVGGL AKLLQGSRTP RSMPAGRTKT GMTVITCSVL
FCMPVSTSKG ESQINRIVFD RNCGTMND
//
