ID   A0A016VWL1_9BILA        Unreviewed;       717 AA.
AC   A0A016VWL1;
DT   11-JUN-2014, integrated into UniProtKB/TrEMBL.
DT   11-JUN-2014, sequence version 1.
DT   27-MAR-2024, entry version 27.
DE   RecName: Full=Reverse transcriptase domain-containing protein {ECO:0000259|Pfam:PF00078};
GN   Name=Acey_s0003.g1196 {ECO:0000313|EMBL:EYC31711.1};
GN   ORFNames=Y032_0003g1196 {ECO:0000313|EMBL:EYC31711.1};
OS   Ancylostoma ceylanicum.
OC   Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC   Rhabditina; Rhabditomorpha; Strongyloidea; Ancylostomatidae;
OC   Ancylostomatinae; Ancylostoma.
OX   NCBI_TaxID=53326 {ECO:0000313|EMBL:EYC31711.1, ECO:0000313|Proteomes:UP000024635};
RN   [1] {ECO:0000313|Proteomes:UP000024635}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=HY135 {ECO:0000313|Proteomes:UP000024635};
RX   PubMed=25730766; DOI=10.1038/ng.3237;
RA   Schwarz E.M., Hu Y., Antoshechkin I., Miller M.M., Sternberg P.W.,
RA   Aroian R.V.;
RT   "The genome and transcriptome of the zoonotic hookworm Ancylostoma
RT   ceylanicum identify infection-specific gene families.";
RL   Nat. Genet. 47:416-422(2015).
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:EYC31711.1}.
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DR   EMBL; JARK01001339; EYC31711.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A016VWL1; -.
DR   STRING; 53326.A0A016VWL1; -.
DR   Proteomes; UP000024635; Unassembled WGS sequence.
DR   CDD; cd01650; RT_nLTR_like; 1.
DR   Gene3D; 3.30.70.270; -; 1.
DR   Gene3D; 3.60.10.10; Endonuclease/exonuclease/phosphatase; 1.
DR   InterPro; IPR043502; DNA/RNA_pol_sf.
DR   InterPro; IPR036691; Endo/exonu/phosph_ase_sf.
DR   InterPro; IPR043128; Rev_trsase/Diguanyl_cyclase.
DR   InterPro; IPR000477; RT_dom.
DR   PANTHER; PTHR19446:SF475; REVERSE TRANSCRIPTASE DOMAIN-CONTAINING PROTEIN; 1.
DR   PANTHER; PTHR19446; REVERSE TRANSCRIPTASES; 1.
DR   Pfam; PF00078; RVT_1; 2.
DR   SUPFAM; SSF56672; DNA/RNA polymerases; 1.
DR   SUPFAM; SSF56219; DNase I-like; 1.
PE   4: Predicted;
KW   Reference proteome {ECO:0000313|Proteomes:UP000024635}.
FT   DOMAIN          517..598
FT                   /note="Reverse transcriptase"
FT                   /evidence="ECO:0000259|Pfam:PF00078"
FT   DOMAIN          626..699
FT                   /note="Reverse transcriptase"
FT                   /evidence="ECO:0000259|Pfam:PF00078"
FT   REGION          1..31
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   717 AA;  79991 MW;  65EBDDAE37AF8C46 CRC64;
     MWNTVNARTS PGSDLQEARP PPVVKKRGLP RDERPRLKTL VRVGSLNVGT LTGKRNGVAI
     AVSGPLKEHV SSVIRVSDKI ISLRIATKDG FWTVVSVYAP QCGCTEAGKE AFYEELDDVI
     RSAPEGDSMT VAGNFNGHVG QDRQGFERVH GGIGFGRRNQ EGERNIELAE AHDLAIASTF
     FIKRESQKIT YCSGGRQSEI DHILVRRQFL KTVKDVKTIP GEEIAGQHRP VVADVCIALP
     KQTKAVREPR IRWWKLTGET QTFREKIAAI GLPDPCGLID PVWASATSII LTCARDTLGE
     TKGGRRGDRA TWFWNEDVQK MVKAKKDAYK AWQKTKSLSM LAEYKLKKKK AKAAVSRAKN
     AAMDELYDKL ESSQAEKHVF RLAKAHRRAS LDVTEVRAVK NEEGEVLRDA VAVKERWRAY
     FEHLLNEEFP RKERNSAEPV AGQEQPWTVD VVRMAMKKMK AGKASGPDGI PVKAWRSLGE
     LGVRWLTMFF NNITRSEKIP EAWKDSIIVP IFKRKGDAVN CVNYRGIKLI AHTMKIYERL
     LDMRLRDMVE IASDQFGFVP ERSTIDAILI ARQVMEKYHK KNKPCHIAFL DLEKAYDSGG
     APRISLEPIP MTLDTVVKHL LEGPPFTLLY ADDVALIADS RAELQLQIQK WQSALADAGL
     KLNPRKTEIM SSLGGDDVVL DANGTAFTQA EQFQYLGSIL SADGTVDAAV RGRIACA
//