ID A0A016VXK9_9BILA Unreviewed; 1081 AA.
AC A0A016VXK9;
DT 11-JUN-2014, integrated into UniProtKB/TrEMBL.
DT 11-JUN-2014, sequence version 1.
DT 27-MAR-2024, entry version 30.
DE RecName: Full=Anion exchange protein {ECO:0000256|RuleBase:RU362035};
GN Name=Acey_s0003.g1423 {ECO:0000313|EMBL:EYC32140.1};
GN Synonyms=Acey-abts-1 {ECO:0000313|EMBL:EYC32140.1};
GN ORFNames=Y032_0003g1423 {ECO:0000313|EMBL:EYC32140.1};
OS Ancylostoma ceylanicum.
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Rhabditina; Rhabditomorpha; Strongyloidea; Ancylostomatidae;
OC Ancylostomatinae; Ancylostoma.
OX NCBI_TaxID=53326 {ECO:0000313|EMBL:EYC32140.1, ECO:0000313|Proteomes:UP000024635};
RN [1] {ECO:0000313|Proteomes:UP000024635}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=HY135 {ECO:0000313|Proteomes:UP000024635};
RX PubMed=25730766; DOI=10.1038/ng.3237;
RA Schwarz E.M., Hu Y., Antoshechkin I., Miller M.M., Sternberg P.W.,
RA Aroian R.V.;
RT "The genome and transcriptome of the zoonotic hookworm Ancylostoma
RT ceylanicum identify infection-specific gene families.";
RL Nat. Genet. 47:416-422(2015).
CC -!- SUBCELLULAR LOCATION: Basolateral cell membrane
CC {ECO:0000256|ARBA:ARBA00004554}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004554}. Cell membrane
CC {ECO:0000256|ARBA:ARBA00004651}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004651}. Lateral cell membrane
CC {ECO:0000256|ARBA:ARBA00034693}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00034693}. Membrane
CC {ECO:0000256|ARBA:ARBA00004141, ECO:0000256|RuleBase:RU362035}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141,
CC ECO:0000256|RuleBase:RU362035}.
CC -!- SIMILARITY: Belongs to the anion exchanger (TC 2.A.31) family.
CC {ECO:0000256|ARBA:ARBA00010993, ECO:0000256|RuleBase:RU362035}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:EYC32140.1}.
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DR EMBL; JARK01001339; EYC32140.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A016VXK9; -.
DR Proteomes; UP000024635; Unassembled WGS sequence.
DR GO; GO:0016323; C:basolateral plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0016328; C:lateral plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0008509; F:monoatomic anion transmembrane transporter activity; IEA:InterPro.
DR GO; GO:0005452; F:solute:inorganic anion antiporter activity; IEA:InterPro.
DR Gene3D; 1.10.287.570; Helical hairpin bin; 1.
DR InterPro; IPR013769; Band3_cytoplasmic_dom.
DR InterPro; IPR011531; HCO3_transpt-like_TM_dom.
DR InterPro; IPR003020; HCO3_transpt_euk.
DR InterPro; IPR003024; Na/HCO3_transpt.
DR InterPro; IPR016152; PTrfase/Anion_transptr.
DR NCBIfam; TIGR00834; ae; 1.
DR PANTHER; PTHR11453; ANION EXCHANGE PROTEIN; 1.
DR PANTHER; PTHR11453:SF36; ANION EXCHANGE PROTEIN; 1.
DR Pfam; PF07565; Band_3_cyto; 1.
DR Pfam; PF00955; HCO3_cotransp; 1.
DR PRINTS; PR01231; HCO3TRNSPORT.
DR PRINTS; PR01232; NAHCO3TRSPRT.
DR SUPFAM; SSF55804; Phoshotransferase/anion transport protein; 1.
PE 3: Inferred from homology;
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Ion transport {ECO:0000256|ARBA:ARBA00023065,
KW ECO:0000256|RuleBase:RU362035};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|RuleBase:RU362035};
KW Reference proteome {ECO:0000313|Proteomes:UP000024635};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW ECO:0000256|RuleBase:RU362035};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|RuleBase:RU362035};
KW Transport {ECO:0000256|ARBA:ARBA00022448, ECO:0000256|RuleBase:RU362035}.
FT TRANSMEM 428..449
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362035"
FT TRANSMEM 458..476
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362035"
FT TRANSMEM 513..539
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362035"
FT TRANSMEM 545..563
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362035"
FT TRANSMEM 646..663
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362035"
FT TRANSMEM 683..703
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362035"
FT TRANSMEM 731..750
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362035"
FT TRANSMEM 776..800
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362035"
FT TRANSMEM 831..851
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362035"
FT TRANSMEM 857..883
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362035"
FT DOMAIN 71..340
FT /note="Band 3 cytoplasmic"
FT /evidence="ECO:0000259|Pfam:PF07565"
FT DOMAIN 399..908
FT /note="Bicarbonate transporter-like transmembrane"
FT /evidence="ECO:0000259|Pfam:PF00955"
FT REGION 374..394
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1035..1071
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 374..392
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1081 AA; 121249 MW; 2298E14B6A834F1D CRC64;
MSMGFVSSDD CRRRRMSKKR ESIELASLAP GTRVMFLLKE NDDTPALFTE MGELGHNEWR
ETARWVKFEE DVEQGGNRWS KPHVATLSLH SLFQLRSCLL NGLFLNDLPH TDLPAIIEAL
IDEFVKVGDV EEDMRDELRE ILMRKHVHQY EQAKKNGPNG DKSGFLSTVR SISDIGKSFS
HGKNLGKLDK DQPQIGPQLE LPKVESMPRD MSKDGSSADI SKGNTHFMKK LPHGVEASNV
LIGEVDFLQR HICAFVRLKT ANVLGDLTEV PVPTRFIFLM LGPTGHGPQY KEIGRAIATL
MADEIFHDVA YKARNKEDLL DGVDEFLDQV TVLPPGEWDP TIRIEPPNQI PSQEKRKQIG
QELLLENVEL AKGKTPGKDE LEEEEAGHGS DPALRRTGRL FGGLILDIKR KAPHFVSDFT
DALNLQCLAT ICFMYFALLA PIVTFGGLLE EATHQRMAAM ENLFGGAICG VVYHLFSGQP
LTIIGSTGPV LVFETIVYDF CLRLGIQYLS FRFWVHVWTA FIIFVMCITD ASSLVSYITR
FTEESFATLI AVIFIYEAIM KLWKIKNQLD VINYSREVVE GTCFCQAPTG KPLVSFEKAG
EFIRKNGLSI AHNSTYIDYS AASLENCRFV GGGFGGTSCY PMYDKLLMSI LLTIGTFFLA
ITFKKMRNSC YFPSRIRQLF SDFAVMISIV IMTCIDMIVG INTPKLNVPS SFRPTWDGRG
WFIPPFDGNP IWTVPLAALP ALLACILIFM DQQITTVIVN RKENKLKKGC GYHLDLLVLA
ILILIVGFLG LPIYVAATVL SINHINSLKV ESECKAPGEV AQFVGVREQR VTGIITFLMI
GLSVLITTFL GRIPMPVLYG VFLYMGISAL GGIQLFDRIL LLLMPMKHQP DTIYIRHVPI
KKIHLFTAFQ VGCLAVLWTV KSIKTTSITF PIMLVVMVAV RKLMEKFFTV TDLKYLDDPM
PDFHLRKKED LKRRQSEGEP VDIELEENQA TIHAVKTEAH LHIPMASGNV IKIPLAAIQE
PSHSINMTKE VNSSGMWKHI SSRDSRNSLN KEMPKISQSD APLETPEDDE DAIMIKFRGN
S
//
