ID A0A016VZZ0_9BILA Unreviewed; 810 AA.
AC A0A016VZZ0;
DT 11-JUN-2014, integrated into UniProtKB/TrEMBL.
DT 11-JUN-2014, sequence version 1.
DT 27-MAR-2024, entry version 29.
DE RecName: Full=Aminopeptidase N-like N-terminal domain-containing protein {ECO:0000259|Pfam:PF17900};
GN Name=Acey_s0002.g506 {ECO:0000313|EMBL:EYC32911.1};
GN Synonyms=Acey-mnp-1 {ECO:0000313|EMBL:EYC32911.1};
GN ORFNames=Y032_0002g506 {ECO:0000313|EMBL:EYC32911.1};
OS Ancylostoma ceylanicum.
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Rhabditina; Rhabditomorpha; Strongyloidea; Ancylostomatidae;
OC Ancylostomatinae; Ancylostoma.
OX NCBI_TaxID=53326 {ECO:0000313|EMBL:EYC32911.1, ECO:0000313|Proteomes:UP000024635};
RN [1] {ECO:0000313|Proteomes:UP000024635}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=HY135 {ECO:0000313|Proteomes:UP000024635};
RX PubMed=25730766; DOI=10.1038/ng.3237;
RA Schwarz E.M., Hu Y., Antoshechkin I., Miller M.M., Sternberg P.W.,
RA Aroian R.V.;
RT "The genome and transcriptome of the zoonotic hookworm Ancylostoma
RT ceylanicum identify infection-specific gene families.";
RL Nat. Genet. 47:416-422(2015).
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:EYC32911.1}.
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DR EMBL; JARK01001338; EYC32911.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A016VZZ0; -.
DR Proteomes; UP000024635; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR Gene3D; 1.10.390.10; Neutral Protease Domain 2; 1.
DR Gene3D; 2.60.40.1730; tricorn interacting facor f3 domain; 1.
DR InterPro; IPR045357; Aminopeptidase_N-like_N.
DR InterPro; IPR042097; Aminopeptidase_N-like_N_sf.
DR InterPro; IPR027268; Peptidase_M4/M1_CTD_sf.
DR PANTHER; PTHR11533; PROTEASE M1 ZINC METALLOPROTEASE; 1.
DR PANTHER; PTHR11533:SF192; PROTEIN CBG20905; 1.
DR Pfam; PF17900; Peptidase_M1_N; 1.
DR SUPFAM; SSF63737; Leukotriene A4 hydrolase N-terminal domain; 1.
DR SUPFAM; SSF55486; Metalloproteases ('zincins'), catalytic domain; 1.
PE 4: Predicted;
KW Membrane {ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000024635};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 12..36
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 204..384
FT /note="Aminopeptidase N-like N-terminal"
FT /evidence="ECO:0000259|Pfam:PF17900"
FT REGION 49..125
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 49..91
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 103..125
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 810 AA; 89090 MW; 7FC0861C3AE08D5E CRC64;
MSDSVKKPKS SLLLYLLIVV TVLVLLCAAT ILYLVAGSRT LTEQPQNATS SQLFLVPDST
PGTPSSSPNS PRDNARPTRP IPSRTTTTTA AVSPPPPSPT ARTTSTNVPA TTVTTSTTTT
TTDTTASLFE YTTTTTTTTT PESAEVTSPV PTEEEAFEEI TISGSHTDAN AEVVDKCASI
VAQRVTCPKT RDDVIALPPS ALSPLHYSLN LSIETVMPTQ LNGDVQIYIR ANEAGKQITL
DVDNELRNVE DIHVVNCDTG ATLCVAKTVF DQREQHLSII LYDIVEAGTN LRVDVLKFTS
VDNRDVTYAQ IAPRWNRNAP IMVGSLLAAG SAKKIFPAMD SPAYRASLDL CVSFTPAGHI
RSNAATKSVE NGLTCFERTV PLSTQQMAFA AFEKAETLIY NRTTLDGVNV PAVEIVFSLN
KNFRREKHEW IYNEASKVIA LMTQWTSFPY PLAALKLFSA PIRASSHSAL GLITLQDRLV
EHPSYTLAHV SLIHSVILQW LSGIVSMSSA DESCFTESLT TYLEWKINEQ LNIVNKTRAG
EIEAIRPKDL SAEGRDDARM LRSLEMMQSC PERFVSIFYT IDETFGQDTV INMLKLVFRK
FAYSVTSISD WQQAVVQATG NHYAGQMLSE WFTRKTRPIL HMHVMAQALQ FEQITDELWT
VPVEVAGSSG VQLVAVTDKA MVIPYSSHDY VIADPRRKSS AMIVHDVDSY VRMIRCWDDT
RCPASHSAVR GIVRDLAAVL LTNKLPAPQI HDVPKWKAVF KFAQSHRILE GNAACCAEYA
ISRTADIACT WVIRDTCEKI ALIQKVANGV
//
