ID   A0A016W036_9BILA        Unreviewed;       842 AA.
AC   A0A016W036;
DT   11-JUN-2014, integrated into UniProtKB/TrEMBL.
DT   11-JUN-2014, sequence version 1.
DT   27-MAR-2024, entry version 41.
DE   RecName: Full=RasGEF domain protein {ECO:0008006|Google:ProtNLM};
GN   Name=Acey_s0003.g1544 {ECO:0000313|EMBL:EYC32388.1};
GN   Synonyms=Acey-epac-1 {ECO:0000313|EMBL:EYC32388.1};
GN   ORFNames=Y032_0003g1544 {ECO:0000313|EMBL:EYC32388.1};
OS   Ancylostoma ceylanicum.
OC   Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC   Rhabditina; Rhabditomorpha; Strongyloidea; Ancylostomatidae;
OC   Ancylostomatinae; Ancylostoma.
OX   NCBI_TaxID=53326 {ECO:0000313|EMBL:EYC32388.1, ECO:0000313|Proteomes:UP000024635};
RN   [1] {ECO:0000313|Proteomes:UP000024635}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=HY135 {ECO:0000313|Proteomes:UP000024635};
RX   PubMed=25730766; DOI=10.1038/ng.3237;
RA   Schwarz E.M., Hu Y., Antoshechkin I., Miller M.M., Sternberg P.W.,
RA   Aroian R.V.;
RT   "The genome and transcriptome of the zoonotic hookworm Ancylostoma
RT   ceylanicum identify infection-specific gene families.";
RL   Nat. Genet. 47:416-422(2015).
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:EYC32388.1}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; JARK01001339; EYC32388.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A016W036; -.
DR   Proteomes; UP000024635; Unassembled WGS sequence.
DR   GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:UniProtKB-KW.
DR   GO; GO:0007264; P:small GTPase mediated signal transduction; IEA:InterPro.
DR   CDD; cd00038; CAP_ED; 1.
DR   CDD; cd00155; RasGEF; 1.
DR   Gene3D; 1.10.8.1240; -; 1.
DR   Gene3D; 2.60.120.10; Jelly Rolls; 1.
DR   Gene3D; 1.10.840.10; Ras guanine-nucleotide exchange factors catalytic domain; 1.
DR   Gene3D; 1.20.870.10; Son of sevenless (SoS) protein Chain: S domain 1; 1.
DR   Gene3D; 1.10.10.10; Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain; 1.
DR   InterPro; IPR000595; cNMP-bd_dom.
DR   InterPro; IPR018490; cNMP-bd_dom_sf.
DR   InterPro; IPR000591; DEP_dom.
DR   InterPro; IPR008937; Ras-like_GEF.
DR   InterPro; IPR000651; Ras-like_Gua-exchang_fac_N.
DR   InterPro; IPR019804; Ras_G-nucl-exch_fac_CS.
DR   InterPro; IPR023578; Ras_GEF_dom_sf.
DR   InterPro; IPR001895; RASGEF_cat_dom.
DR   InterPro; IPR036964; RASGEF_cat_dom_sf.
DR   InterPro; IPR014710; RmlC-like_jellyroll.
DR   InterPro; IPR029071; Ubiquitin-like_domsf.
DR   InterPro; IPR036388; WH-like_DNA-bd_sf.
DR   InterPro; IPR036390; WH_DNA-bd_sf.
DR   PANTHER; PTHR23113:SF327; EXCHANGE PROTEIN DIRECTLY ACTIVATED BY CAMP, ISOFORM E; 1.
DR   PANTHER; PTHR23113; GUANINE NUCLEOTIDE EXCHANGE FACTOR; 1.
DR   Pfam; PF00027; cNMP_binding; 1.
DR   Pfam; PF00610; DEP; 1.
DR   Pfam; PF00617; RasGEF; 1.
DR   PRINTS; PR00103; CAMPKINASE.
DR   SMART; SM00100; cNMP; 1.
DR   SMART; SM00049; DEP; 1.
DR   SMART; SM00147; RasGEF; 1.
DR   SMART; SM00229; RasGEFN; 1.
DR   SUPFAM; SSF51206; cAMP-binding domain-like; 1.
DR   SUPFAM; SSF48366; Ras GEF; 1.
DR   SUPFAM; SSF54236; Ubiquitin-like; 1.
DR   SUPFAM; SSF46785; Winged helix' DNA-binding domain; 1.
DR   PROSITE; PS50042; CNMP_BINDING_3; 1.
DR   PROSITE; PS50186; DEP; 1.
DR   PROSITE; PS00720; RASGEF; 1.
DR   PROSITE; PS50009; RASGEF_CAT; 1.
DR   PROSITE; PS50212; RASGEF_NTER; 1.
PE   4: Predicted;
KW   Guanine-nucleotide releasing factor {ECO:0000256|ARBA:ARBA00022658,
KW   ECO:0000256|PROSITE-ProRule:PRU00168};
KW   Reference proteome {ECO:0000313|Proteomes:UP000024635}.
FT   DOMAIN          33..114
FT                   /note="DEP"
FT                   /evidence="ECO:0000259|PROSITE:PS50186"
FT   DOMAIN          191..292
FT                   /note="Cyclic nucleotide-binding"
FT                   /evidence="ECO:0000259|PROSITE:PS50042"
FT   DOMAIN          335..480
FT                   /note="N-terminal Ras-GEF"
FT                   /evidence="ECO:0000259|PROSITE:PS50212"
FT   DOMAIN          617..841
FT                   /note="Ras-GEF"
FT                   /evidence="ECO:0000259|PROSITE:PS50009"
SQ   SEQUENCE   842 AA;  95145 MW;  635DC10A68FA40DB CRC64;
     MLTVSNEAIA AYFQSFEARI LEVGSHLKHA MYTQAPHLIR ERIIHKVPYA DCMIGSEMVD
     WLLDLSVSTG AHSPALSRFQ ISGMWQTLLE HNVICHVTGE LQFVDKLVCY RWVDGGRTDR
     RMANGVPGRF PLGDPRLKEE VPSREDIASA VFFLSTVGPD ALFRMILKKL PQDRTPEELE
     LVYEELLHVK ALSHLSTMVK RELATVIGYE HHTHAGTVLF HQGDPGKNWY IILRGSVDVS
     IHGKGVVCTL QEGDDFGKLA LVNDSPRAAT ITLREDHAQF LTVDKHDFNR ILRDVEANTV
     RLKEHGQDVL VLEKINLPRG AAIEGGLTNT GKGHCCYSVM AGLAEKMLEY VLETRVDAQE
     DGAELDVFLE DLVLTHIIYL PTNTLCNYLK HYYSRAAEPH SDPLVVLDDL EHRLSARRRV
     VTFLWLWVNA LGIHYFLDPA ANAFVEELYC HVLEDHRTLP GMGPILARIS ALRDLREEAR
     RTLARHPAVV LECGVLSTMA PSPNPVLPSD ICNQIIHLSD TTSFALPIRM DKTATEICEL
     VRSRLRSSHG EELALVEVKS SGEKVVFYDG DVSIATMLSL NSKLYVVSKD EIDSLVPQLD
     QNGPVESVHA SVMEYVGSHE LAQQLLVLHT QLFEATDEIE LVTQVIGRDQ FPGRVPSNLD
     LLMRRFNEVQ YWATTEVLLA LPQKRVNTLR KFIKIAMYAK ENRDLMTLFA ITLGLSNIAV
     SRLTHLWERL PAKLRRQFAE FESLLDPSRN HRPYRALVAK MSPPLIPFVP LLLKDLTFIH
     EGNKTYYNGL VNFEKMHMIA NILRSFRQCK SRYSGTLVNF PDNVSKNIFP CFSYTNGAEE
     NL
//