ID A0A016W0F5_9BILA Unreviewed; 2510 AA.
AC A0A016W0F5;
DT 11-JUN-2014, integrated into UniProtKB/TrEMBL.
DT 11-JUN-2014, sequence version 1.
DT 27-MAR-2024, entry version 28.
DE SubName: Full=Uncharacterized protein {ECO:0000313|EMBL:EYC32488.1};
GN Name=Acey_s0003.g1609 {ECO:0000313|EMBL:EYC32488.1};
GN ORFNames=Y032_0003g1609 {ECO:0000313|EMBL:EYC32488.1};
OS Ancylostoma ceylanicum.
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Rhabditina; Rhabditomorpha; Strongyloidea; Ancylostomatidae;
OC Ancylostomatinae; Ancylostoma.
OX NCBI_TaxID=53326 {ECO:0000313|EMBL:EYC32488.1, ECO:0000313|Proteomes:UP000024635};
RN [1] {ECO:0000313|Proteomes:UP000024635}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=HY135 {ECO:0000313|Proteomes:UP000024635};
RX PubMed=25730766; DOI=10.1038/ng.3237;
RA Schwarz E.M., Hu Y., Antoshechkin I., Miller M.M., Sternberg P.W.,
RA Aroian R.V.;
RT "The genome and transcriptome of the zoonotic hookworm Ancylostoma
RT ceylanicum identify infection-specific gene families.";
RL Nat. Genet. 47:416-422(2015).
CC -!- SIMILARITY: Belongs to the VPS13 family.
CC {ECO:0000256|ARBA:ARBA00006545}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:EYC32488.1}.
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DR EMBL; JARK01001339; EYC32488.1; -; Genomic_DNA.
DR Proteomes; UP000024635; Unassembled WGS sequence.
DR InterPro; IPR015412; Atg2/VPS13_C.
DR InterPro; IPR026847; VPS13.
DR InterPro; IPR049424; VPS13_C.
DR InterPro; IPR031645; VPS13_DH-like.
DR InterPro; IPR031642; VPS13_mid_RBG.
DR InterPro; IPR009543; VPS13_VAB.
DR PANTHER; PTHR16166:SF93; INTERMEMBRANE LIPID TRANSFER PROTEIN VPS13; 1.
DR PANTHER; PTHR16166; VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN VPS13; 1.
DR Pfam; PF09333; ATG2-VPS13_C; 1.
DR Pfam; PF21679; VPS13_C; 1.
DR Pfam; PF16909; VPS13_DH-like; 1.
DR Pfam; PF16910; VPS13_mid_rpt; 2.
DR Pfam; PF06650; VPS13_VAB; 1.
PE 3: Inferred from homology;
KW Reference proteome {ECO:0000313|Proteomes:UP000024635}.
FT DOMAIN 1..91
FT /note="VPS13 middle RBG modules"
FT /evidence="ECO:0000259|Pfam:PF16910"
FT DOMAIN 451..645
FT /note="VPS13 middle RBG modules"
FT /evidence="ECO:0000259|Pfam:PF16910"
FT DOMAIN 1270..1790
FT /note="Vacuolar protein sorting-associated protein 13 VPS13
FT adaptor binding"
FT /evidence="ECO:0000259|Pfam:PF06650"
FT DOMAIN 2102..2278
FT /note="Vacuolar protein sorting-associated protein 13 DH-
FT like"
FT /evidence="ECO:0000259|Pfam:PF16909"
FT DOMAIN 2285..2360
FT /note="Atg2/VPS13 C-terminal"
FT /evidence="ECO:0000259|Pfam:PF09333"
FT DOMAIN 2372..2489
FT /note="Intermembrane lipid transfer protein VPS13 C-
FT terminal"
FT /evidence="ECO:0000259|Pfam:PF21679"
FT REGION 128..152
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 652..711
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 864..884
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 128..145
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 669..697
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 2510 AA; 279904 MW; F25478870D774142 CRC64;
MDKAYDKFRV KLSNVVVSMA ENVAKGRASL GDKESPLHIL KPTGLDIQIH KCSIDDLRLP
RMRIIGALPD IVIGISDIRL LDLTRLLLSI PKPEPDPEVA AIEEKLIEST EIKVKDRAKM
KTIMEVQEIE SDEKPAQEAA ADDSQKSKTS EQQVQLELDL HLNQIGVIVL RKDDVLCEVS
ILRMGCKLQM RTFDMVVTAE LGAIRVSMPM FKSIDPKRKC LYFIDNNEEE GSLMTLKFIQ
ANPESPFFAT EYQSTEQYIE FKFRKLLVSL HQEGLMELKQ FGEKMQAEMN ALQKVEEKPV
EEAIEQGARK LSRQISGSVE SLAAVSRDAQ KQAAAVKKRR GKRSAAEEEE QAARVIKMRL
EATIGSLGVA IGTEKSLETW IAIENIRADV KMTVKAMNVI ATLQTVKMED MTEGSLYRKL
LSVAGEKEML RFEMVQYQRT DEQKKLMQPS DIDMSVKVRL AQMRFIFLNL WLCRLMAWMA
PFQEEAARAA AAAQAAASEK AAEAAQNVKQ MLAESPPRIQ LDVQLEAPII VVPQLSKSRN
ALVLILGKLM VNNHITGDRQ NPKIIMDRME VKLMDMTFGI GRMGDDASTF DMKCEVLEPL
SFNIAVHRNL VFAIAKDLPE LTVDAQIPSL AVKMSEHDYN TVMQTLSGNL AEGSELAVPP
PPPPSQCKDS SDSKEKETTT EEGEDKLQLE KKKLSTKASS APKAVATPAP APVEAPKPKI
VFQFTLDNIV AVLYMGGSDE SGVRNVNDAF AAMRLHGLKL SGTIKEDNSM NVAISLNTFT
MADERREKTK IHMLLDKKNA NQADRFLALA FSQDAQQNKN VKLKMSAFFI CLCPEFLGCL
SRFFTVDKTE EDLQNEVEAI KAVGGSKPTA AQTTAAASDG PDTPPPSIVL DCDMQGVEVI
LVENSMEPDT TQALILSFNM KMAAHPSPTE QVMSGGIEKL AMFSSYYAQS RRNEVTYEVL
KPMNIGIEMR IDTPTKATNL VLKMSPMEVR MSPSIIRLLS AVNAEFAKSS AVDQKTTTVS
SPKPREFPNY WKPKRIDQKK FWFFTVPTAQ EACDENEGTA SNRAPVEHAH VEMERMNFTL
EAGDSSVPVP LIFMQILMNA EASGWSSALQ ASADLSLQMS YYNEASSVWE PVIEPVEVST
DNWSPWNLKM TVKGRNKMDP LDSRPGMDVK IEADDILNIT ITKSFLSLLN KVSEAFAHAA
KQISPPTTRQ LPGTSAFLVL NETGMIIKMS DSDTLQVSEN GEDVEAPHGR FVDLRMNKEA
AAVAAESQDK ERLSTNQVEL KADLRINLLD TVRNIKIGRA GKIAVPLPKK SDGGKQWKVI
VETSIENGRR LITFTSHVEV TNHLDVPMEL YSKNNTSLDM FGTVAPGETL KLVVPLLFSA
TGEIYFRPAN DNASLSSRCE VSFESVTWHQ FTHQKRQVIR CDLSEDTTKG YFFETVVLEE
KVREGIDQYT EVYSLHLYPP LQFHNILPFP VTLEIPVAMD LGPGENLQLN MVPGHRLRLW
APYLGEMYAL DMTIPEEKKD LEVVALNTET GSSELLLGIH WSTEHGDLKA YLYAPFWLVN
NTSMTLKHME LEYAVKHLPD ENPLILPFPS TDFTKKKKSR VLVEEAGAWS QEFPLDTVGN
PARITCKGKD RDYELTVNIQ LCQSGLTKIV TFCPFYLVSN LGKWDMQVRE EGQSTWTDVP
AEKCVGIWPQ QRSKRKFLCA RYAGQQQESL LFPFTENFET LCHIDNDNVG VEVCVSTSES
SVAIHLTPFQ PGMAPVCIMN NLNIPINFGQ KGHTMQTVAT NEMVYFTWDN VTEERTMQFT
VGDFKGEDKL DQNKLDELKL DANVRKFAYT ANFLIGQQRV MLFTRDLDIA RTAYGSWETD
TVDMQAELAL QGVGLSIVDN NVGKELLYIG ISSSDILWEE EVKKGRFKPF AVKIMQALEE
KYQEHLVEPK KEYEPIDAYE VCMETMIMRK KKGKEVKIRR IFEKGIWASY GKSAERTRLH
LKINHLQVDN QLETCVFPRV LAVVPPPKSV MADNAPKPFV EISLLQRQSE FSKVPEIEYA
RMLVQEFAVQ VDQGLINALL ALVASEVNKQ AYGKEMFETD MKTSLVRLED TAKQYRSNQP
RSFYNDLHIS PLMIHLSFSQ GGTTGEGSSG AMPIQSEFFK VLFQSVGVSV TELQDVVFKL
AYFERKRVFY RSDQLNSEII SHYTMQALRQ MYVLVLGLDI IGNPFGLVRD LSAGVEDLFY
QPFQGLVLGP EEFATGVALG VQSMFGHAVG GAAGAVGRIT GTVGKGVAAL TFDAEYQRKR
QEDLNRKPQS FGEGMARGVK GLGMGVVEGI TGVVTKPIEG AKQEGGLGFV KGVGKGLIGV
VTRPVSGVVD FASSTMHSVR TVAGAGKEAG ALRPPRVIRP DHIIRPYSHY EALGFKIFND
TDRGAIADTD EFITYAPITD KIVLLVTNAQ LVLSKRTDMM GTWATDWQTE YDKIKEPIFV
ENGIKLVLKE KKRGFLGIGS TEGKIITFAN AEAIQQKVMA AYKAATELPI
//
