ID A0A016W1V4_9BILA Unreviewed; 317 AA.
AC A0A016W1V4;
DT 11-JUN-2014, integrated into UniProtKB/TrEMBL.
DT 11-JUN-2014, sequence version 1.
DT 27-MAR-2024, entry version 33.
DE RecName: Full=TGF-beta family profile domain-containing protein {ECO:0000259|PROSITE:PS51362};
GN Name=Acey_s0001.g123 {ECO:0000313|EMBL:EYC33849.1};
GN Synonyms=Acey-daf-7 {ECO:0000313|EMBL:EYC33849.1};
GN ORFNames=Y032_0001g123 {ECO:0000313|EMBL:EYC33849.1};
OS Ancylostoma ceylanicum.
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Rhabditina; Rhabditomorpha; Strongyloidea; Ancylostomatidae;
OC Ancylostomatinae; Ancylostoma.
OX NCBI_TaxID=53326 {ECO:0000313|EMBL:EYC33849.1, ECO:0000313|Proteomes:UP000024635};
RN [1] {ECO:0000313|Proteomes:UP000024635}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=HY135 {ECO:0000313|Proteomes:UP000024635};
RX PubMed=25730766; DOI=10.1038/ng.3237;
RA Schwarz E.M., Hu Y., Antoshechkin I., Miller M.M., Sternberg P.W.,
RA Aroian R.V.;
RT "The genome and transcriptome of the zoonotic hookworm Ancylostoma
RT ceylanicum identify infection-specific gene families.";
RL Nat. Genet. 47:416-422(2015).
CC -!- SIMILARITY: Belongs to the TGF-beta family.
CC {ECO:0000256|ARBA:ARBA00006656, ECO:0000256|RuleBase:RU000354}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:EYC33849.1}.
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DR EMBL; JARK01001337; EYC33849.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A016W1V4; -.
DR Proteomes; UP000024635; Unassembled WGS sequence.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-KW.
DR GO; GO:0008083; F:growth factor activity; IEA:UniProtKB-KW.
DR CDD; cd19378; TGF_beta_DAF7; 1.
DR Gene3D; 2.10.90.10; Cystine-knot cytokines; 1.
DR InterPro; IPR029034; Cystine-knot_cytokine.
DR InterPro; IPR001839; TGF-b_C.
DR InterPro; IPR015615; TGF-beta-rel.
DR InterPro; IPR017948; TGFb_CS.
DR PANTHER; PTHR11848:SF297; DAUER LARVA DEVELOPMENT REGULATORY GROWTH FACTOR DAF-7; 1.
DR PANTHER; PTHR11848; TGF-BETA FAMILY; 1.
DR Pfam; PF00019; TGF_beta; 1.
DR SMART; SM00204; TGFB; 1.
DR SUPFAM; SSF57501; Cystine-knot cytokines; 1.
DR PROSITE; PS00250; TGF_BETA_1; 1.
DR PROSITE; PS51362; TGF_BETA_2; 1.
PE 3: Inferred from homology;
KW Growth factor {ECO:0000256|ARBA:ARBA00023030,
KW ECO:0000256|RuleBase:RU000354};
KW Reference proteome {ECO:0000313|Proteomes:UP000024635};
KW Secreted {ECO:0000256|ARBA:ARBA00022525}.
FT DOMAIN 200..317
FT /note="TGF-beta family profile"
FT /evidence="ECO:0000259|PROSITE:PS51362"
SQ SEQUENCE 317 AA; 35826 MW; 2FE86243D3CD99F4 CRC64;
MKMAKIAAIK EHLLEAMNMK DYAALRVPKK VKAEFSSIIR GMEKEERHQQ KDDDALEKTF
IFAVDPSKGN DRTTLVAQFP VSEQTKQRNI VKATLQVFLS LNEELNEATK VLISVKERLQ
DGLLGDEVAS KTVHILKSTR VSVHLRPSDL RRWWAEEPIE GLFVEAIVDG QNVAVHPQTT
DQPTENMLLS LQLQSSSPTR SRRQVTPVCT ETMKEPGCCL YDLYVDFVEF GWDFILAPQR
YNAYICRGDC MKKEPSSIAH TRLATTGPVD PALLKTHALN CCHPSEYDTI KIVYLNQKNQ
MTVAKLDGMI ARKCSCS
//
