ID A0A016WAQ1_9BILA Unreviewed; 738 AA.
AC A0A016WAQ1;
DT 11-JUN-2014, integrated into UniProtKB/TrEMBL.
DT 11-JUN-2014, sequence version 1.
DT 27-MAR-2024, entry version 33.
DE RecName: Full=General transcription and DNA repair factor IIH helicase subunit XPB {ECO:0000256|ARBA:ARBA00014343};
DE EC=3.6.4.12 {ECO:0000256|ARBA:ARBA00012551};
GN Name=Acey_s0843.g2641 {ECO:0000313|EMBL:EYC36919.1};
GN Synonyms=Acey-Y66D12A.15 {ECO:0000313|EMBL:EYC36919.1};
GN ORFNames=Y032_0843g2641 {ECO:0000313|EMBL:EYC36919.1};
OS Ancylostoma ceylanicum.
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Rhabditina; Rhabditomorpha; Strongyloidea; Ancylostomatidae;
OC Ancylostomatinae; Ancylostoma.
OX NCBI_TaxID=53326 {ECO:0000313|EMBL:EYC36919.1, ECO:0000313|Proteomes:UP000024635};
RN [1] {ECO:0000313|Proteomes:UP000024635}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=HY135 {ECO:0000313|Proteomes:UP000024635};
RX PubMed=25730766; DOI=10.1038/ng.3237;
RA Schwarz E.M., Hu Y., Antoshechkin I., Miller M.M., Sternberg P.W.,
RA Aroian R.V.;
RT "The genome and transcriptome of the zoonotic hookworm Ancylostoma
RT ceylanicum identify infection-specific gene families.";
RL Nat. Genet. 47:416-422(2015).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + H2O = ADP + H(+) + phosphate; Xref=Rhea:RHEA:13065,
CC ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616,
CC ChEBI:CHEBI:43474, ChEBI:CHEBI:456216; EC=3.6.4.12;
CC Evidence={ECO:0000256|ARBA:ARBA00001665};
CC -!- SIMILARITY: Belongs to the helicase family. RAD25/XPB subfamily.
CC {ECO:0000256|ARBA:ARBA00006637}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:EYC36919.1}.
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DR EMBL; JARK01000443; EYC36919.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A016WAQ1; -.
DR Proteomes; UP000024635; Unassembled WGS sequence.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-KW.
DR GO; GO:0005524; F:ATP binding; IEA:InterPro.
DR GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR GO; GO:0003678; F:DNA helicase activity; IEA:InterPro.
DR GO; GO:0016787; F:hydrolase activity; IEA:InterPro.
DR GO; GO:0006289; P:nucleotide-excision repair; IEA:InterPro.
DR GO; GO:0006367; P:transcription initiation at RNA polymerase II promoter; IEA:InterPro.
DR CDD; cd18029; DEXHc_XPB; 1.
DR CDD; cd18789; SF2_C_XPB; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 2.
DR InterPro; IPR032438; ERCC3_RAD25_C.
DR InterPro; IPR006935; Helicase/UvrB_N.
DR InterPro; IPR014001; Helicase_ATP-bd.
DR InterPro; IPR001650; Helicase_C.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR001161; XPB/Ssl2.
DR InterPro; IPR032830; XPB/Ssl2_N.
DR NCBIfam; TIGR00603; rad25; 1.
DR PANTHER; PTHR11274:SF0; GENERAL TRANSCRIPTION AND DNA REPAIR FACTOR IIH HELICASE SUBUNIT XPB; 1.
DR PANTHER; PTHR11274; RAD25/XP-B DNA REPAIR HELICASE; 1.
DR Pfam; PF16203; ERCC3_RAD25_C; 1.
DR Pfam; PF13625; Helicase_C_3; 1.
DR Pfam; PF04851; ResIII; 1.
DR PRINTS; PR00851; XRODRMPGMNTB.
DR SMART; SM00487; DEXDc; 1.
DR SMART; SM00490; HELICc; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 2.
DR PROSITE; PS51192; HELICASE_ATP_BIND_1; 1.
DR PROSITE; PS51194; HELICASE_CTER; 1.
PE 3: Inferred from homology;
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Reference proteome {ECO:0000313|Proteomes:UP000024635}.
FT DOMAIN 299..466
FT /note="Helicase ATP-binding"
FT /evidence="ECO:0000259|PROSITE:PS51192"
FT DOMAIN 520..672
FT /note="Helicase C-terminal"
FT /evidence="ECO:0000259|PROSITE:PS51194"
FT REGION 188..215
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 683..738
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 197..215
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 706..723
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 738 AA; 84250 MW; 10A657CF3B55966E CRC64;
MIMHRRRGAA QQTGDGCRSQ VFFGTIVDVS LLFPIEPADL PADTTAVADH ASRPLWVAPD
GHIFLESFSP VYKHARDFLI AISEPVCRPE HIHEYQLTAY SLYAAVSVGL QTNDIIEYLE
RLSKSALPRG IVEFIKMCTL SYGKVKLVLK HNRYFVESRH SDVIQKLLKD KVIQSCILEE
EKPVEETQTQ IEKINFPQEQ TKEEEKKPEG EDVPEDIGEL YGKMDGDDEE DAEIRSLQLL
TFEIKQESIE TVQKRCIELE YPLLAEYDFR NDTMNPNLGI DLKPSTTLRP YQEKSLRKMF
GNSRARSGVI VLPCGAGKTL VGVTAVTTVN KRCLCLANSN VSVEQWRAQF KLWSTITDKQ
IVRFTREAKD TVPHGPDASK PVVCISTYSM VAYAGKRTYA AEEAMKFIES QEWGLLLLDE
VHTIPAKMFR RVLTIVQAHC KLGLTATLVR EDDKITDLNF LIGPKIYEAN WMELQKAGHI
AKVQCAEVWC PMTSEFYAYY LRAQIARRLL LAVMNPNKFR ICQFLIKFHE RRNDKIIVFS
DNVFALKKYA IEMNKPFLYG ETSQNERMKI LQNFQYNPRV NTIFVSKVAD TSFDLPEANV
LIQVSAHGGS RRQEAQRLGR ILRAKKHSTD QFNAFFYSLV SQDTVEMGYS RKRQRFLVNQ
GYAYKESQLQ LLQQVLAASD ADAEEEDVKE EMADGTIRVS RREATMASVS GGSSVSYSNK
SKQALADRHP LFKRFREK
//
