ID A0A016WAW6_9BILA Unreviewed; 933 AA.
AC A0A016WAW6;
DT 11-JUN-2014, integrated into UniProtKB/TrEMBL.
DT 11-JUN-2014, sequence version 1.
DT 27-MAR-2024, entry version 36.
DE RecName: Full=Amiloride-sensitive sodium channel {ECO:0008006|Google:ProtNLM};
GN Name=Acey_s0857.g2718 {ECO:0000313|EMBL:EYC36780.1};
GN ORFNames=Y032_0857g2718 {ECO:0000313|EMBL:EYC36780.1};
OS Ancylostoma ceylanicum.
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Rhabditina; Rhabditomorpha; Strongyloidea; Ancylostomatidae;
OC Ancylostomatinae; Ancylostoma.
OX NCBI_TaxID=53326 {ECO:0000313|EMBL:EYC36780.1, ECO:0000313|Proteomes:UP000024635};
RN [1] {ECO:0000313|Proteomes:UP000024635}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=HY135 {ECO:0000313|Proteomes:UP000024635};
RX PubMed=25730766; DOI=10.1038/ng.3237;
RA Schwarz E.M., Hu Y., Antoshechkin I., Miller M.M., Sternberg P.W.,
RA Aroian R.V.;
RT "The genome and transcriptome of the zoonotic hookworm Ancylostoma
RT ceylanicum identify infection-specific gene families.";
RL Nat. Genet. 47:416-422(2015).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the amiloride-sensitive sodium channel (TC
CC 1.A.6) family. {ECO:0000256|ARBA:ARBA00007193,
CC ECO:0000256|RuleBase:RU000679}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:EYC36780.1}.
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DR EMBL; JARK01000457; EYC36780.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A016WAW6; -.
DR STRING; 53326.A0A016WAW6; -.
DR Proteomes; UP000024635; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005272; F:sodium channel activity; IEA:UniProtKB-KW.
DR Gene3D; 2.60.470.10; Acid-sensing ion channels like domains; 1.
DR Gene3D; 1.10.287.770; YojJ-like; 1.
DR InterPro; IPR001873; ENaC.
DR PANTHER; PTHR11690; AMILORIDE-SENSITIVE SODIUM CHANNEL-RELATED; 1.
DR PANTHER; PTHR11690:SF261; DEGENERIN-LIKE PROTEIN DEL-10; 1.
DR Pfam; PF00858; ASC; 2.
PE 3: Inferred from homology;
KW Ion channel {ECO:0000256|RuleBase:RU000679};
KW Ion transport {ECO:0000256|RuleBase:RU000679};
KW Membrane {ECO:0000256|ARBA:ARBA00023136};
KW Reference proteome {ECO:0000313|Proteomes:UP000024635};
KW Sodium {ECO:0000256|ARBA:ARBA00023053};
KW Sodium channel {ECO:0000256|ARBA:ARBA00022461,
KW ECO:0000256|RuleBase:RU000679};
KW Sodium transport {ECO:0000256|ARBA:ARBA00023201,
KW ECO:0000256|RuleBase:RU000679};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW ECO:0000256|RuleBase:RU000679};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989};
KW Transport {ECO:0000256|RuleBase:RU000679}.
FT REGION 770..933
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 779..801
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 822..860
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 861..898
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT NON_TER 1
FT /evidence="ECO:0000313|EMBL:EYC36780.1"
SQ SEQUENCE 933 AA; 107577 MW; 643F2832DED1E30B CRC64;
LTYITGARIL NRRARASNGT LKSLSGKPRN VFEEALQRSW DMDAVRFLRN AAHWKSRMIL
GCTWPNGTSC RLSDFKPVWT MSGLCWAINT NPHNPLQVVG SGVGHSIRLL LNVETYERID
ACTTHFRTKS LPGLKILIYN QTSLPVTNQN GLNVPSGYAM DIRFRMQHHN RLPGLHCTAE
TAEHKKASEE FNSTLNIRTC EVRKTLREIE YECECSMARA FTTEPMATTR PCNVDDYFGC
VRGVVEKSME EGSRRDCLPP CESVEYVAWQ DLNRLPQNVM PALIEGHEEE DESDVEQDDI
EEDKYLTLRN RTDEKFFLCE ENAYLDATQV SYIKRDAHRA YEKQARHQED IFLRTKRRIV
RLRTAVWNVS QLHWGWHGDD FVGVFERLTE GAACFANFSV RHESISAVME SRPAYSEEKR
ASQLFFLIDP EAQRANPKKF KSIGDVKRYY GDQVDAALKE LQDVGETVEK MWHLFTPSTY
EGAVLADVVR MDRIVELMTQ YETGRLQRRV WAEKMQSKRM RHFFEDDFSE GWYQPIVHDL
EHSLYKVVLE VEREYWPKFL SYVQNGTAMK TGALLFFDDV TNANEEKFKN IITDMYNCTV
GDVKKVAHET LKDFKRLYRE LQSSYTNLFK KELTEYLENF EFGSKFVSDN FAMVNVFLQQ
MHLERWSQDR TYGFWSLACD VGGALGLFLG ASMLTIIELV YLCYQYRICG KLFKKTDNRV
RECWNENCQH LRWCKSCQTK SLKTSYVSSD HGGSLTSPLE ERQKSSWLTP FSEYSPTHSA
RNRKGERSSV DFADTAEDLQ PPRYEDTIGM NDSAHVGDHK GMSQSPSEET RGHDRLAGII
EDDSGLESDG GDRSRLKRTS RILEPSTQSK HPEPYQKAQQ TALKEHGPST GRPSLQDNPQ
KSQEDEDMSQ MTDSLSTTAP KLFSDVIERH TTL
//
