ID A0A016WBG2_9BILA Unreviewed; 686 AA.
AC A0A016WBG2;
DT 11-JUN-2014, integrated into UniProtKB/TrEMBL.
DT 11-JUN-2014, sequence version 1.
DT 27-MAR-2024, entry version 39.
DE RecName: Full=Hepatocyte growth factor-regulated tyrosine kinase substrate {ECO:0000256|ARBA:ARBA00015450};
GN Name=Acey_s0840.g2625 {ECO:0000313|EMBL:EYC36965.1};
GN Synonyms=Acey-hgrs-1 {ECO:0000313|EMBL:EYC36965.1};
GN ORFNames=Y032_0840g2625 {ECO:0000313|EMBL:EYC36965.1};
OS Ancylostoma ceylanicum.
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Rhabditina; Rhabditomorpha; Strongyloidea; Ancylostomatidae;
OC Ancylostomatinae; Ancylostoma.
OX NCBI_TaxID=53326 {ECO:0000313|EMBL:EYC36965.1, ECO:0000313|Proteomes:UP000024635};
RN [1] {ECO:0000313|Proteomes:UP000024635}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=HY135 {ECO:0000313|Proteomes:UP000024635};
RX PubMed=25730766; DOI=10.1038/ng.3237;
RA Schwarz E.M., Hu Y., Antoshechkin I., Miller M.M., Sternberg P.W.,
RA Aroian R.V.;
RT "The genome and transcriptome of the zoonotic hookworm Ancylostoma
RT ceylanicum identify infection-specific gene families.";
RL Nat. Genet. 47:416-422(2015).
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:EYC36965.1}.
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DR EMBL; JARK01000440; EYC36965.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A016WBG2; -.
DR Proteomes; UP000024635; Unassembled WGS sequence.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProt.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0035091; F:phosphatidylinositol binding; IEA:InterPro.
DR GO; GO:0043130; F:ubiquitin binding; IEA:InterPro.
DR CDD; cd15720; FYVE_Hrs; 1.
DR CDD; cd21387; GAT_Hrs; 1.
DR Gene3D; 1.20.5.1940; -; 1.
DR Gene3D; 1.25.40.90; -; 1.
DR Gene3D; 3.30.40.10; Zinc/RING finger domain, C3HC4 (zinc finger); 1.
DR InterPro; IPR008942; ENTH_VHS.
DR InterPro; IPR017073; HGS/VPS27.
DR InterPro; IPR024641; HRS_helical.
DR InterPro; IPR003903; UIM_dom.
DR InterPro; IPR002014; VHS_dom.
DR InterPro; IPR000306; Znf_FYVE.
DR InterPro; IPR017455; Znf_FYVE-rel.
DR InterPro; IPR011011; Znf_FYVE_PHD.
DR InterPro; IPR013083; Znf_RING/FYVE/PHD.
DR PANTHER; PTHR46275; HEPATOCYTE GROWTH FACTOR-REGULATED TYROSINE KINASE SUBSTRATE; 1.
DR PANTHER; PTHR46275:SF1; HEPATOCYTE GROWTH FACTOR-REGULATED TYROSINE KINASE SUBSTRATE; 1.
DR Pfam; PF01363; FYVE; 1.
DR Pfam; PF12210; Hrs_helical; 1.
DR Pfam; PF00790; VHS; 1.
DR PIRSF; PIRSF036956; Hrs_Vps27; 1.
DR SMART; SM00064; FYVE; 1.
DR SMART; SM00288; VHS; 1.
DR SUPFAM; SSF48464; ENTH/VHS domain; 1.
DR SUPFAM; SSF57903; FYVE/PHD zinc finger; 1.
DR PROSITE; PS50330; UIM; 1.
DR PROSITE; PS50179; VHS; 1.
DR PROSITE; PS50178; ZF_FYVE; 1.
PE 4: Predicted;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Reference proteome {ECO:0000313|Proteomes:UP000024635};
KW Zinc {ECO:0000256|ARBA:ARBA00022833};
KW Zinc-finger {ECO:0000256|ARBA:ARBA00022771, ECO:0000256|PROSITE-
KW ProRule:PRU00091}.
FT DOMAIN 1..95
FT /note="VHS"
FT /evidence="ECO:0000259|PROSITE:PS50179"
FT DOMAIN 112..172
FT /note="FYVE-type"
FT /evidence="ECO:0000259|PROSITE:PS50178"
FT REGION 263..284
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 537..557
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 582..686
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 190..220
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 424..474
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 596..612
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 638..669
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 686 AA; 76399 MW; 17D035A790EF05E4 CRC64;
MRKRIQHDNP HVVMHALLVL DACVKNCGHK IHAEVATREF MEEFKNLGIG SQYEDVKTKV
LEMLQCWAMA FANKPEYKIV VDTHNLMKLA GFDFPSIKEA DAMFTAQVAP DWHDGTECFR
CRAEFSLFNR KHHCRACGQI FCDRCSTKEL PLPQFGIERE VRVCDACYEK ATSKTGEAKV
VKNEPGTSTS ANAEVTQAEK EKLLREKEEE ELALALAISQ SEAEAKEQER QKSLYALYNG
DTTGTSVIND AASLSSYNPS EMGYKGAAPS IAESPSDNLP TDDPLARYLN RDYWQQRKAG
AATKVEEWAG ASASAPLPSE TSIAPANNAV ASVQAELTQL SLNHSPSMSD DLKAQTEGTM
KWCQQLKEQV TVMENRIRSN NARGRSVLND TAIQGLFSTL TEFHSQVLGA LTKLEEERTY
YESLQDHLGH ISEARLAIDE LRAEHERRRQ ERLAEEQRQR QAQMKQTLEM MRMKKHVMLM
EQRNVALQRF QHQEMQARRG QMPPAGYYAG YGQQQGVPTQ GNYPGYVMPG YQGYPQQPYT
SQPSYQQYPP SSVVPGTTQW QDAVAPAQQV QYANPAAHTA ALSNGGALQP PQHQSQPQAQ
PQPQPQPYYA PVQAAGPAPY HQQPAEALPV APGAAPTLHG SSGQQTQLPQ YPPTQHPYHL
QNPVNGTEMP AAQQPEPVEQ PLISFD
//
