ID A0A016WGY8_9BILA Unreviewed; 1198 AA.
AC A0A016WGY8;
DT 11-JUN-2014, integrated into UniProtKB/TrEMBL.
DT 11-JUN-2014, sequence version 1.
DT 27-MAR-2024, entry version 42.
DE RecName: Full=Bromo domain-containing protein {ECO:0000259|PROSITE:PS50014};
GN Name=Acey_s0727.g1881 {ECO:0000313|EMBL:EYC38293.1};
GN Synonyms=Acey-lex-1 {ECO:0000313|EMBL:EYC38293.1};
GN ORFNames=Y032_0727g1881 {ECO:0000313|EMBL:EYC38293.1};
OS Ancylostoma ceylanicum.
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Rhabditina; Rhabditomorpha; Strongyloidea; Ancylostomatidae;
OC Ancylostomatinae; Ancylostoma.
OX NCBI_TaxID=53326 {ECO:0000313|EMBL:EYC38293.1, ECO:0000313|Proteomes:UP000024635};
RN [1] {ECO:0000313|Proteomes:UP000024635}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=HY135 {ECO:0000313|Proteomes:UP000024635};
RX PubMed=25730766; DOI=10.1038/ng.3237;
RA Schwarz E.M., Hu Y., Antoshechkin I., Miller M.M., Sternberg P.W.,
RA Aroian R.V.;
RT "The genome and transcriptome of the zoonotic hookworm Ancylostoma
RT ceylanicum identify infection-specific gene families.";
RL Nat. Genet. 47:416-422(2015).
CC -!- SIMILARITY: Belongs to the AAA ATPase family.
CC {ECO:0000256|ARBA:ARBA00006914}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:EYC38293.1}.
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DR EMBL; JARK01000327; EYC38293.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A016WGY8; -.
DR Proteomes; UP000024635; Unassembled WGS sequence.
DR GO; GO:0005524; F:ATP binding; IEA:InterPro.
DR GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR Gene3D; 1.10.8.60; -; 1.
DR Gene3D; 1.20.920.10; Bromodomain-like; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR InterPro; IPR003593; AAA+_ATPase.
DR InterPro; IPR041569; AAA_lid_3.
DR InterPro; IPR045199; ATAD2-like.
DR InterPro; IPR003959; ATPase_AAA_core.
DR InterPro; IPR003960; ATPase_AAA_CS.
DR InterPro; IPR001487; Bromodomain.
DR InterPro; IPR036427; Bromodomain-like_sf.
DR InterPro; IPR018359; Bromodomain_CS.
DR InterPro; IPR027417; P-loop_NTPase.
DR PANTHER; PTHR23069; AAA DOMAIN-CONTAINING; 1.
DR PANTHER; PTHR23069:SF0; TAT-BINDING HOMOLOG 7; 1.
DR Pfam; PF00004; AAA; 1.
DR Pfam; PF17862; AAA_lid_3; 1.
DR Pfam; PF00439; Bromodomain; 1.
DR PRINTS; PR00503; BROMODOMAIN.
DR SMART; SM00382; AAA; 1.
DR SMART; SM00297; BROMO; 1.
DR SUPFAM; SSF47370; Bromodomain; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 2.
DR PROSITE; PS00674; AAA; 1.
DR PROSITE; PS00633; BROMODOMAIN_1; 1.
DR PROSITE; PS50014; BROMODOMAIN_2; 1.
PE 3: Inferred from homology;
KW Bromodomain {ECO:0000256|ARBA:ARBA00023117, ECO:0000256|PROSITE-
KW ProRule:PRU00035}; Reference proteome {ECO:0000313|Proteomes:UP000024635}.
FT DOMAIN 880..950
FT /note="Bromo"
FT /evidence="ECO:0000259|PROSITE:PS50014"
FT REGION 85..273
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1084..1108
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 85..140
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 141..168
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 170..187
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 220..239
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 240..255
FT /note="Basic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1084..1103
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1198 AA; 135929 MW; 0ACBF66D8D7BBE58 CRC64;
MVYRSLAEND LAEHHLRGSF MKSIIRSATE QLHKELISGQ PVAGYTRSGR RIAGGIHYEE
SDSTDEDDYE KRRRRRRFAK ERYNDENVDI RSPSPKRCSV KRRGAVEDEE DHEKEQKQED
SEQHEDPHSN MYDNIKRERK TVTTSLPNSP RLTNGTESSR SLRQANRERL SNGVAKEEPV
VEVEGSRSSE ETEEDDEKTP EPRQYSLRKI RQPVDRFAST VTPRERHRED RERRSRGRST
DRRDRKAKRA AKRRRRELRS DSSSTSSSDS DDIIRTRNDD LRFERRKERS LAKARNRYLP
INLSDKDLSA SQAVIRERLR QTGGSCTDID PMSIDSGIGF EQVGGLGSHI QSLKEVVLFP
MLYPEIFKQF NIMPPKGVVF YGPPGTGKTL MARALANECS KGGKKVAFFM RKGADCLSKW
VGEAERQLRV LFDQAYAMRP SIIFFDEIDG LAPVRSSKQD QIHSSIVSTL LALMDGLDNR
GEVVVIGATN RLDTLDPALR RPGRFDRELK FSLPDANARM QILTIHTSKW GDSQPDEETL
RWLADGTSGY CGADLQYLCT EAVLVALRSR FPHIYMSKER LKLDPSDLVI DKNCFTTAMR
RITPASRRDL SIPSRQLDER TSILLLSTVT SILNIRIPTG YRSSQSVQNT AATELEKVVR
ALEQPPCVPA VRLMLCGSEE HPDLGQTSYV LPAVLGKLDH LPVFSIAVAR LFADGRPEET
LAQTVQSALR AAASGPCILL LPSIDQWYEV VPPSVAHMLA TALDSLHGFT SILFLASCDC
AYDSCCNEVK DLFGPSQCLS LRPPKEQHRR RYFEHILASA RIPPKVFDPS LYQEPEKAGD
EVATTSRKLN EKEARELVKI YESQLRRFRI WARDKLSALR RDRRFTIFVK PVDSEDVEDY
YDVIKNPMCI SEMEEKIDRQ EYLHPDHLLS DIRLIRDNAI EYNPVNTEEG RVIRHNAHAL
WETVVDLFDV DLDVDFVESL ENNAKMLADA GVQPTNEKLL ELPPGFKRTV PWSVNAGYMT
QLVKESAKEA NGEKREAQTS AVTNNVQRVK FRNHRRNRGG YAFPNSAKKK KTAAIVKSLK
RSLANSVDES SGSQTSQAGS EEESVENGDC MEIEAEKQKS PQTKKKLILP EDKINELVNT
CVHRSNGWSV SELERLAAVL AHDIEEFRDK WDRSSLPSKL LATVNSWQVN SGRVFASV
//
