ID A0A016WL32_9BILA Unreviewed; 318 AA.
AC A0A016WL32;
DT 11-JUN-2014, integrated into UniProtKB/TrEMBL.
DT 11-JUN-2014, sequence version 1.
DT 27-MAR-2024, entry version 25.
DE RecName: Full=Peptidase C1A papain C-terminal domain-containing protein {ECO:0000259|SMART:SM00645};
GN Name=Acey_s0619.g723 {ECO:0000313|EMBL:EYC40311.1};
GN ORFNames=Y032_0619g723 {ECO:0000313|EMBL:EYC40311.1};
OS Ancylostoma ceylanicum.
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Rhabditina; Rhabditomorpha; Strongyloidea; Ancylostomatidae;
OC Ancylostomatinae; Ancylostoma.
OX NCBI_TaxID=53326 {ECO:0000313|EMBL:EYC40311.1, ECO:0000313|Proteomes:UP000024635};
RN [1] {ECO:0000313|Proteomes:UP000024635}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=HY135 {ECO:0000313|Proteomes:UP000024635};
RX PubMed=25730766; DOI=10.1038/ng.3237;
RA Schwarz E.M., Hu Y., Antoshechkin I., Miller M.M., Sternberg P.W.,
RA Aroian R.V.;
RT "The genome and transcriptome of the zoonotic hookworm Ancylostoma
RT ceylanicum identify infection-specific gene families.";
RL Nat. Genet. 47:416-422(2015).
CC -!- SIMILARITY: Belongs to the peptidase C1 family.
CC {ECO:0000256|ARBA:ARBA00008455}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:EYC40311.1}.
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DR EMBL; JARK01000219; EYC40311.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A016WL32; -.
DR Proteomes; UP000024635; Unassembled WGS sequence.
DR GO; GO:0008234; F:cysteine-type peptidase activity; IEA:UniProtKB-KW.
DR GO; GO:0006508; P:proteolysis; IEA:UniProtKB-KW.
DR CDD; cd02620; Peptidase_C1A_CathepsinB; 1.
DR Gene3D; 3.90.70.10; Cysteine proteinases; 1.
DR InterPro; IPR038765; Papain-like_cys_pep_sf.
DR InterPro; IPR000169; Pept_cys_AS.
DR InterPro; IPR025660; Pept_his_AS.
DR InterPro; IPR013128; Peptidase_C1A.
DR InterPro; IPR000668; Peptidase_C1A_C.
DR PANTHER; PTHR12411:SF894; CATHEPSIN B-LIKE CYSTEINE PROTEINASE 6; 1.
DR PANTHER; PTHR12411; CYSTEINE PROTEASE FAMILY C1-RELATED; 1.
DR Pfam; PF00112; Peptidase_C1; 1.
DR PRINTS; PR00705; PAPAIN.
DR SMART; SM00645; Pept_C1; 1.
DR SUPFAM; SSF54001; Cysteine proteinases; 1.
DR PROSITE; PS00139; THIOL_PROTEASE_CYS; 1.
DR PROSITE; PS00639; THIOL_PROTEASE_HIS; 1.
PE 3: Inferred from homology;
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Protease {ECO:0000256|ARBA:ARBA00022670};
KW Reference proteome {ECO:0000313|Proteomes:UP000024635};
KW Thiol protease {ECO:0000256|ARBA:ARBA00022807}.
FT DOMAIN 78..318
FT /note="Peptidase C1A papain C-terminal"
FT /evidence="ECO:0000259|SMART:SM00645"
SQ SEQUENCE 318 AA; 36125 MW; 6714A0BF72875653 CRC64;
MLLLLTLIIA SVVADDNAIG EQQLTGRALA DYVRTHQNLF EVEESEKNDE RMKYLMPASY
MTTPSDVERI EVEADEEPPE RFDAREQWPY CKEIIGTIRD QSRCGSCWAV SAAETMSDRL
CIQSKGKYKL HLSDSDILAC CGLPCGYGCE GGWPIKAWQF IMRYGVCTGG KYGAKGVCKP
YSFHPCGNHK NQMYYGECPE GSWPTPNCKK FCQRGYTKPY NKDKFYAKSA YQLPKDEKKI
RQEIMKNGPV QAGYYVYEDF RLYKGGIYKH KTGMQTGGHA VKIIGWGKEK VNGTDVPYWL
IANSWSVDWG EEGELMIS
//
