ID A0A016WPM4_9BILA Unreviewed; 1199 AA.
AC A0A016WPM4;
DT 11-JUN-2014, integrated into UniProtKB/TrEMBL.
DT 11-JUN-2014, sequence version 1.
DT 27-MAR-2024, entry version 36.
DE RecName: Full=Sec23/Sec24 trunk domain protein {ECO:0008006|Google:ProtNLM};
GN Name=Acey_s0587.g344 {ECO:0000313|EMBL:EYC40978.1};
GN Synonyms=Acey-sec-24.2 {ECO:0000313|EMBL:EYC40978.1};
GN ORFNames=Y032_0587g344 {ECO:0000313|EMBL:EYC40978.1};
OS Ancylostoma ceylanicum.
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Rhabditina; Rhabditomorpha; Strongyloidea; Ancylostomatidae;
OC Ancylostomatinae; Ancylostoma.
OX NCBI_TaxID=53326 {ECO:0000313|EMBL:EYC40978.1, ECO:0000313|Proteomes:UP000024635};
RN [1] {ECO:0000313|Proteomes:UP000024635}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=HY135 {ECO:0000313|Proteomes:UP000024635};
RX PubMed=25730766; DOI=10.1038/ng.3237;
RA Schwarz E.M., Hu Y., Antoshechkin I., Miller M.M., Sternberg P.W.,
RA Aroian R.V.;
RT "The genome and transcriptome of the zoonotic hookworm Ancylostoma
RT ceylanicum identify infection-specific gene families.";
RL Nat. Genet. 47:416-422(2015).
CC -!- SUBCELLULAR LOCATION: Cytoplasmic vesicle, COPII-coated vesicle
CC membrane {ECO:0000256|ARBA:ARBA00004299}; Peripheral membrane protein
CC {ECO:0000256|ARBA:ARBA00004299}; Cytoplasmic side
CC {ECO:0000256|ARBA:ARBA00004299}. Endoplasmic reticulum membrane
CC {ECO:0000256|ARBA:ARBA00004397}; Peripheral membrane protein
CC {ECO:0000256|ARBA:ARBA00004397}; Cytoplasmic side
CC {ECO:0000256|ARBA:ARBA00004397}. Membrane
CC {ECO:0000256|ARBA:ARBA00004287}; Peripheral membrane protein
CC {ECO:0000256|ARBA:ARBA00004287}; Cytoplasmic side
CC {ECO:0000256|ARBA:ARBA00004287}.
CC -!- SIMILARITY: Belongs to the SEC23/SEC24 family. SEC24 subfamily.
CC {ECO:0000256|ARBA:ARBA00008334}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:EYC40978.1}.
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DR EMBL; JARK01000187; EYC40978.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A016WPM4; -.
DR Proteomes; UP000024635; Unassembled WGS sequence.
DR GO; GO:0030127; C:COPII vesicle coat; IEA:InterPro.
DR GO; GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005794; C:Golgi apparatus; IEA:UniProtKB-KW.
DR GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR GO; GO:0006888; P:endoplasmic reticulum to Golgi vesicle-mediated transport; IEA:InterPro.
DR GO; GO:0006886; P:intracellular protein transport; IEA:InterPro.
DR Gene3D; 2.60.40.1670; beta-sandwich domain of Sec23/24; 3.
DR Gene3D; 1.20.120.730; Sec23/Sec24 helical domain; 1.
DR Gene3D; 3.40.50.410; von Willebrand factor, type A domain; 1.
DR Gene3D; 2.30.30.380; Zn-finger domain of Sec23/24; 1.
DR InterPro; IPR036180; Gelsolin-like_dom_sf.
DR InterPro; IPR006900; Sec23/24_helical_dom.
DR InterPro; IPR036175; Sec23/24_helical_dom_sf.
DR InterPro; IPR006896; Sec23/24_trunk_dom.
DR InterPro; IPR012990; Sec23_24_beta_S.
DR InterPro; IPR036465; vWFA_dom_sf.
DR InterPro; IPR006895; Znf_Sec23_Sec24.
DR PANTHER; PTHR13803; SEC24-RELATED PROTEIN; 1.
DR PANTHER; PTHR13803:SF39; SECRETORY 24AB, ISOFORM A; 1.
DR Pfam; PF08033; Sec23_BS; 1.
DR Pfam; PF04815; Sec23_helical; 1.
DR Pfam; PF04811; Sec23_trunk; 2.
DR Pfam; PF04810; zf-Sec23_Sec24; 1.
DR SUPFAM; SSF81995; beta-sandwich domain of Sec23/24; 2.
DR SUPFAM; SSF82754; C-terminal, gelsolin-like domain of Sec23/24; 1.
DR SUPFAM; SSF81811; Helical domain of Sec23/24; 1.
DR SUPFAM; SSF53300; vWA-like; 1.
PE 3: Inferred from homology;
KW Cytoplasmic vesicle {ECO:0000256|ARBA:ARBA00023329};
KW Golgi apparatus {ECO:0000256|ARBA:ARBA00023034};
KW Protein transport {ECO:0000256|ARBA:ARBA00022927};
KW Reference proteome {ECO:0000313|Proteomes:UP000024635};
KW Transport {ECO:0000256|ARBA:ARBA00022448}.
FT DOMAIN 331..363
FT /note="Zinc finger Sec23/Sec24-type"
FT /evidence="ECO:0000259|Pfam:PF04810"
FT DOMAIN 700..742
FT /note="Sec23/Sec24 trunk"
FT /evidence="ECO:0000259|Pfam:PF04811"
FT DOMAIN 743..853
FT /note="Sec23/Sec24 trunk"
FT /evidence="ECO:0000259|Pfam:PF04811"
FT DOMAIN 859..941
FT /note="Sec23/Sec24 beta-sandwich"
FT /evidence="ECO:0000259|Pfam:PF08033"
FT DOMAIN 952..1055
FT /note="Sec23/Sec24 helical"
FT /evidence="ECO:0000259|Pfam:PF04815"
FT REGION 1..163
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 427..576
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 20..47
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 64..97
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 101..125
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 137..163
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 439..472
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 476..500
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 512..540
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 541..555
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 556..576
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1199 AA; 132255 MW; 3C6E38FD104D7C43 CRC64;
MANPSNAIPP KVGFPQAFGN SPYQHASQFP QYAHPATAAQ PQPSGVVRAN PFQPPPGVTQ
FPSPPSLPQQ SQAVNGLPQE SAFPSAPSHS GVNGPSSAFK PYGNPPAPAF PAKLPAFPQP
PQRPDQHAPY QVAGAPPPIN QRSSLNPTPT PINPINHSSS LNPSPFPAPG IQPSFPPIPP
IQSKSYNSTP MHATQSTPMS SFPPNINQVQ QSFSQMNMTP VGAMPQPTHP TWGGSYQNDS
RMAAAPAYSS DLVDLMGERN ILQMGFDDIE YCLPHNMANN QARVDPSVFR CTLTMVPQNE
ELLKKSRLPF GLTLHPFRDM KNLNIIQTST IVRCRYCRTY INPYVYLPDS RHWKCNLCNR
NNDRGIHIVG WLTRPMLFLR KWDFPKRLGI PPINTPLSFH NMLILQLLPS LSLLAIHRSG
VVRANPFQPP PGVTQFPSPP SLPQQSQAVN GLPQESAFPS APSHSGVNGP SSAFKPYGNP
PAPAFPAKLP AFPQPPQRPD QHAPYQVAGA PPPINQRSSL NPTPTPINPI NHSSSLNPSP
FPAPGIQPSF PPIPPIQSKS YNSTPMHATQ STPMSSFPPN INQVQQSFSQ MNMTPVGAMP
QPTHPTWGGS YQNDSRMAAA PGYSSDLVDL MGERNILQLG FDDIEYCLPH NMANNQARVD
PSVFRCTLTM VPQNEELLKK SRLPFGLTLH PFRDMKLRPP QPAVYVFVLD VSAAAIEAGY
LFALSEQLLI NLDQLPGDDR TQAEIGGRIT VFQATLPNIG PGCLKPREDP NQRAGTDVQN
LVPATDFYKT LALECTGHQV ALDLFLLNTQ YADLATLSEI AKFSTGCVYH FPNYHCLNDV
VQVKRFEKIF ARYLTRKIGF EAVLRIRCSR GLSLSTFYGN FFVRSTDLLA LANVNPDSAI
AVQVALEEKL STSVCFQAAL LYTSSKGDRR IRVHTMCLPT TADLAQVYNN FDLKATVSLI
AKIGVDRSLT GSPLSDSREA IVNAVVDSLG AYQKTMRQGR AGGLLAPRQG HLRLFPLYAL
AMLKHTSFCA GRSIKLDDRV AAMLMLRFCP LEQILSEFYP QMYRINEILQ FDEGKWPTAL
PLSFEYISRD GIYLIEAGSA LYLYVSSNAG AQLLQDLFGC AYQQIDEHSF RCYDNPFSEK
VHAFVRHVTA LKFYVGPVII VKEESPIREV VVRRLVDDRS ESTHSYVEFL QHIKREINN
//
