ID   A0A016WPN2_9BILA        Unreviewed;       915 AA.
AC   A0A016WPN2;
DT   11-JUN-2014, integrated into UniProtKB/TrEMBL.
DT   11-JUN-2014, sequence version 1.
DT   27-MAR-2024, entry version 30.
DE   RecName: Full=Vinculin family protein {ECO:0008006|Google:ProtNLM};
GN   Name=Acey_s0562.g3489 {ECO:0000313|EMBL:EYC41605.1};
GN   Synonyms=Acey-hmp-1 {ECO:0000313|EMBL:EYC41605.1};
GN   ORFNames=Y032_0562g3489 {ECO:0000313|EMBL:EYC41605.1};
OS   Ancylostoma ceylanicum.
OC   Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC   Rhabditina; Rhabditomorpha; Strongyloidea; Ancylostomatidae;
OC   Ancylostomatinae; Ancylostoma.
OX   NCBI_TaxID=53326 {ECO:0000313|EMBL:EYC41605.1, ECO:0000313|Proteomes:UP000024635};
RN   [1] {ECO:0000313|Proteomes:UP000024635}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=HY135 {ECO:0000313|Proteomes:UP000024635};
RX   PubMed=25730766; DOI=10.1038/ng.3237;
RA   Schwarz E.M., Hu Y., Antoshechkin I., Miller M.M., Sternberg P.W.,
RA   Aroian R.V.;
RT   "The genome and transcriptome of the zoonotic hookworm Ancylostoma
RT   ceylanicum identify infection-specific gene families.";
RL   Nat. Genet. 47:416-422(2015).
CC   -!- SIMILARITY: Belongs to the vinculin/alpha-catenin family.
CC       {ECO:0000256|ARBA:ARBA00008376}.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:EYC41605.1}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; JARK01000162; EYC41605.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A016WPN2; -.
DR   STRING; 53326.A0A016WPN2; -.
DR   Proteomes; UP000024635; Unassembled WGS sequence.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR   GO; GO:0051015; F:actin filament binding; IEA:InterPro.
DR   GO; GO:0045296; F:cadherin binding; IEA:InterPro.
DR   GO; GO:0007155; P:cell adhesion; IEA:InterPro.
DR   Gene3D; 6.10.250.2510; -; 1.
DR   Gene3D; 1.20.120.230; Alpha-catenin/vinculin-like; 5.
DR   InterPro; IPR036723; Alpha-catenin/vinculin-like_sf.
DR   InterPro; IPR001033; Alpha_catenin.
DR   InterPro; IPR006077; Vinculin/catenin.
DR   PANTHER; PTHR18914; ALPHA CATENIN; 1.
DR   PANTHER; PTHR18914:SF9; CATENIN ALPHA; 1.
DR   Pfam; PF01044; Vinculin; 1.
DR   PRINTS; PR00805; ALPHACATENIN.
DR   SUPFAM; SSF47220; alpha-catenin/vinculin-like; 4.
PE   3: Inferred from homology;
KW   Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW   Reference proteome {ECO:0000313|Proteomes:UP000024635}.
FT   REGION          631..662
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   915 AA;  101927 MW;  73B07C4EC694DE32 CRC64;
     MVVRASLQSS FNFDQVKTKT VENLIFQLIN DVTNITETFP LQPGQTADSL VVAVERSVQQ
     FLDQGDAAIR SCPLAHGTAL ETLTDALVDV RDTGQSMSFA GRDFIRDSSS SQRRATAVNA
     GKTLLQAVAH FLILADSIDV ALIVEGIDKI RTLLDGIRAA TSNQEVIDRY QLMIAEIEEI
     EETVRRRIAD LRDPNQRDDL LACKGVLKSS CPLVFATTKA FVRHPENDES RQNRDYAHNE
     ALAALNAMDS ILRGEKPDMS FTAQGRLGHL ISELDQFQNR VYLEPGTYKA HIHRPELEEL
     LERIVSGSAA IADSGSTRAD RKQKIVNECN NLRQALQDLL GEYERSCGRD NSEDVDLAMV
     LVGRKAKDLR RHLRRAVVDH VSDAFLDTNT PLLILIDAAK RRDSEATTQA GHLFLEHANK
     IVDVAHLACE MSSDVEGVRI IRYTANQLRK LAPQVVNAAH LLCARGDSKV AQENMDLFRD
     IWQDKVRLLT MAIDSIMTLD DFLAVSEAHI VEDAMAGLQA VHEGDGDMLD RASGAIRGRS
     LRVCSAVDAE MDALQPSAYT ERVKLATRRL RDEMLSQYAV RAEAVVTRLE ATGPNSTQEE
     RDRDSDEFIN ACTLVHDAVK EIRNALLVNR HPEDVDSDNE YEDDGQTNVH DNTSRISEGE
     NQQKIMRRLP EEDKKKIQEQ IDVFKITQTK FEREVAKWDE SGNDIIVLAK HMCMIMTDMT
     DFTRGHGPLK TTMDVIRAAQ EISVDGSKLN ALAKQIGDES VDSNTKADLF AYLSRITLYC
     QQLNICSKVK ADVQQIGNDV VVSGLESAMS LIQTARNLLG AVVLTVKAAY IASTKCAQSE
     RARVEAAMAL CAPPLYQDDD GKFRRHNSQA PYVQWRMAPP MKQPLVPVQK KHGVIRRASE
     RRPMAPARAL AEFVQ
//