ID   A0A016WUG8_9BILA        Unreviewed;      1090 AA.
AC   A0A016WUG8;
DT   11-JUN-2014, integrated into UniProtKB/TrEMBL.
DT   11-JUN-2014, sequence version 1.
DT   27-MAR-2024, entry version 33.
DE   RecName: Full=CTLH domain-containing protein {ECO:0000259|PROSITE:PS50897};
GN   Name=Acey_s0493.g2430 {ECO:0000313|EMBL:EYC43449.1};
GN   ORFNames=Y032_0493g2430 {ECO:0000313|EMBL:EYC43449.1};
OS   Ancylostoma ceylanicum.
OC   Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC   Rhabditina; Rhabditomorpha; Strongyloidea; Ancylostomatidae;
OC   Ancylostomatinae; Ancylostoma.
OX   NCBI_TaxID=53326 {ECO:0000313|EMBL:EYC43449.1, ECO:0000313|Proteomes:UP000024635};
RN   [1] {ECO:0000313|Proteomes:UP000024635}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=HY135 {ECO:0000313|Proteomes:UP000024635};
RX   PubMed=25730766; DOI=10.1038/ng.3237;
RA   Schwarz E.M., Hu Y., Antoshechkin I., Miller M.M., Sternberg P.W.,
RA   Aroian R.V.;
RT   "The genome and transcriptome of the zoonotic hookworm Ancylostoma
RT   ceylanicum identify infection-specific gene families.";
RL   Nat. Genet. 47:416-422(2015).
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:EYC43449.1}.
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DR   EMBL; JARK01000093; EYC43449.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A016WUG8; -.
DR   Proteomes; UP000024635; Unassembled WGS sequence.
DR   Gene3D; 1.10.287.1490; -; 1.
DR   InterPro; IPR024964; CTLH/CRA.
DR   InterPro; IPR006595; CTLH_C.
DR   InterPro; IPR006594; LisH.
DR   InterPro; IPR040024; PPP1R21.
DR   InterPro; IPR049372; PPP1R21_C.
DR   InterPro; IPR019343; PPP1R21_N.
DR   PANTHER; PTHR21448:SF0; PROTEIN PHOSPHATASE 1 REGULATORY SUBUNIT 21; 1.
DR   PANTHER; PTHR21448; SMOOTH MUSCLE MYOSIN HEAVY CHAIN-RELATED; 1.
DR   Pfam; PF10607; CTLH; 1.
DR   Pfam; PF10205; KLRAQ; 1.
DR   Pfam; PF21636; PPP1R21_C; 1.
DR   SMART; SM01254; KLRAQ; 1.
DR   PROSITE; PS50897; CTLH; 1.
DR   PROSITE; PS50896; LISH; 1.
PE   4: Predicted;
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Reference proteome {ECO:0000313|Proteomes:UP000024635}.
FT   DOMAIN          169..213
FT                   /note="CTLH"
FT                   /evidence="ECO:0000259|PROSITE:PS50897"
FT   REGION          551..575
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          831..850
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          886..905
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          1053..1074
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COILED          1..28
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COILED          428..476
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COILED          507..541
FT                   /evidence="ECO:0000256|SAM:Coils"
SQ   SEQUENCE   1090 AA;  121699 MW;  5D0F5E0F41A3566D CRC64;
     MPETSESLAE IESALNRLSK ELDQFEGTWA ANMSKLLASA ELYDRELLSD DASPEMSVTA
     QMLLEELGAR GEETLTQMLA HHKSLHHGVS QIGKDIDKST HREIGGLIRN EKDIERDPKS
     QRLVDGMVCD YLMTCGHTSI AEILVKEAGL GGRIDGYLAN RKVIDWIMEA LKNQDIGPAI
     AWLKQNPHSD TKLQYDLLKQ HMVALIQEGR RIEAMQFGRQ LSPFGYEQET AQVMGAIVMG
     KDRNDPRYEA LFSPLAWPAL ESRMSVALAQ SDTRFANVIL TGMRAVPILV NLKQVMVNRQ
     DHLFSGEELP VEVKIDDPLA WPALESRMSV ALAQSDTRFA NVILTGMRAV PILVNLKQVM
     VNRQDHLFSG EELPVEVKID EFQWMSVSSV SFNTDVNVRY ERLSTEYAKL RSHVKVLSEG
     VIAERKKNEV FADKIQELES QLHKVDAENE SLTFRNDQLV KRVESLQDEL ETLAHSRAGS
     IKKGKFPKKS KDTKELLSEL GALGDRVLIL EEELQNKIQQ NAELTSKISE LEERHAEELA
     SLSNEFARKL EEAESHKLSS DRRREHKPER PVKSVKPLEQ SVEICNILAE SPSPTPPPIN
     EAYLQAAESA RNSLQGLSTL FELLYQRTQV YPFDATLEAL PNHVRKLSSE LVQCSQLFTP
     SIEIVQRCIE KAEFQLSTDV AELHSCLKVV VRHCRVMMPE LLKRLAVEEN KVTWCDSQLE
     KLNNAWCTDV CRLLVAIDAV SSALAVTAAG DGSGGEKLCA ALEEGFFVVK ELESTFAARW
     VIESRFPTAT KRICCIGTAT TNCLSRLLTE VGKLSARVHA INGLLVENGK EATAPPSERE
     RVTGGYNPFD DDCEEATITE ENVIATEKVS SCSVGVDTSD LMPVSADTPQ NVPNSPTSST
     CSKPENSSVQ LMVDCLKSRV STLEAERESH LVDLSLLRRK LENLGVKEIG DDSQSEIEML
     KQVNRERLRA VTDSLQTAQC ATNYYKGECE ILLRKYFLCM EEKRVLEETV RDMRHELSSL
     TDELASVRRG YDDQLSQMTE HVAELNGKLA GIEKERGGQR TPVTPQRSGR VSSSTEQGFL
     HTFGALALSG
//