ID A0A016WWI8_9BILA Unreviewed; 764 AA.
AC A0A016WWI8;
DT 11-JUN-2014, integrated into UniProtKB/TrEMBL.
DT 11-JUN-2014, sequence version 1.
DT 13-SEP-2023, entry version 43.
DE RecName: Full=PDZ domain-containing protein {ECO:0008006|Google:ProtNLM};
GN Name=Acey_s0488.g2360 {ECO:0000313|EMBL:EYC43607.1};
GN ORFNames=Y032_0488g2360 {ECO:0000313|EMBL:EYC43607.1};
OS Ancylostoma ceylanicum.
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Strongylida;
OC Ancylostomatoidea; Ancylostomatidae; Ancylostomatinae; Ancylostoma.
OX NCBI_TaxID=53326 {ECO:0000313|EMBL:EYC43607.1, ECO:0000313|Proteomes:UP000024635};
RN [1] {ECO:0000313|Proteomes:UP000024635}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=HY135 {ECO:0000313|Proteomes:UP000024635};
RX PubMed=25730766; DOI=10.1038/ng.3237;
RA Schwarz E.M., Hu Y., Antoshechkin I., Miller M.M., Sternberg P.W.,
RA Aroian R.V.;
RT "The genome and transcriptome of the zoonotic hookworm Ancylostoma
RT ceylanicum identify infection-specific gene families.";
RL Nat. Genet. 47:416-422(2015).
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:EYC43607.1}.
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DR EMBL; JARK01000088; EYC43607.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A016WWI8; -.
DR Proteomes; UP000024635; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:InterPro.
DR GO; GO:0045202; C:synapse; IEA:UniProt.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0031267; F:small GTPase binding; IEA:InterPro.
DR GO; GO:0006887; P:exocytosis; IEA:InterPro.
DR GO; GO:0006886; P:intracellular protein transport; IEA:InterPro.
DR CDD; cd00992; PDZ_signaling; 1.
DR Gene3D; 2.30.42.10; -; 1.
DR Gene3D; 3.30.40.10; Zinc/RING finger domain, C3HC4 (zinc finger); 1.
DR InterPro; IPR041282; FYVE_2.
DR InterPro; IPR001478; PDZ.
DR InterPro; IPR036034; PDZ_sf.
DR InterPro; IPR010911; Rab_BD.
DR InterPro; IPR039032; Rim-like.
DR InterPro; IPR017455; Znf_FYVE-rel.
DR InterPro; IPR011011; Znf_FYVE_PHD.
DR InterPro; IPR013083; Znf_RING/FYVE/PHD.
DR PANTHER; PTHR12157:SF21; RAB3 INTERACTING MOLECULE, ISOFORM F; 1.
DR PANTHER; PTHR12157; REGULATING SYNAPTIC MEMBRANE EXOCYTOSIS PROTEIN; 1.
DR Pfam; PF02318; FYVE_2; 1.
DR Pfam; PF00595; PDZ; 1.
DR SMART; SM00228; PDZ; 1.
DR SUPFAM; SSF57903; FYVE/PHD zinc finger; 1.
DR SUPFAM; SSF50156; PDZ domain-like; 1.
DR PROSITE; PS50106; PDZ; 1.
DR PROSITE; PS50916; RABBD; 1.
DR PROSITE; PS50178; ZF_FYVE; 1.
PE 4: Predicted;
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Reference proteome {ECO:0000313|Proteomes:UP000024635};
KW Zinc {ECO:0000256|ARBA:ARBA00022833};
KW Zinc-finger {ECO:0000256|ARBA:ARBA00022771, ECO:0000256|PROSITE-
KW ProRule:PRU00091}.
FT DOMAIN 7..133
FT /note="RabBD"
FT /evidence="ECO:0000259|PROSITE:PS50916"
FT DOMAIN 66..121
FT /note="FYVE-type"
FT /evidence="ECO:0000259|PROSITE:PS50178"
FT DOMAIN 529..618
FT /note="PDZ"
FT /evidence="ECO:0000259|PROSITE:PS50106"
FT REGION 140..205
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 217..449
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 142..180
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 217..231
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 240..278
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 286..307
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 308..361
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 362..377
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 379..401
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 435..449
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 764 AA; 86405 MW; 052DFCB156918D1C CRC64;
MDDPSLMPDL SHLSAEEREI IEQVFKRQKD EEAKEVQLTL KADAELDQID KQINERKEIA
RKLVGTQDDA ICQICQRTKF ADGIGHKCFY CQLRSCARCG GRSHSKNKAI WACSLCQKRQ
QILAKTGKWF QPDEAQHKIS NAGHESPCQN MSPIPFSSPH PSQPQQQDAA FTGTQSHSPH
PESADKNKPS TRVSAPQQPM PSHKPGLVES AVSLLKQAQE PSANGPSSAK TEAPHENVRR
QNTLQRQPSL VEHEQSRQHG NGSLPQKQFS TTRADVNRVE PFVQQRPNML ETQNESGNAG
QGQDKRTTQS TRAREEKRHK ENRPIFYTEP DSRFDEVDRS ELRDEPEPQR MTSKDQRRLP
TSEHGSLQTS SGYRDKPSSP LPSREDEMRR GSWRTHAKNA EIHSSHMSSG TARGKKNRLH
RQTQSMSSSD EELPSTSARY DEEEVRQTPN ECISEKDLLR YIYGPDKVKN SRKSGIIQLR
HSADEFRPAP REPTATLVPG DLLAAKIRTY LSHPVTWQPS ADQRRLIGHM VLHKTDNSRS
GDLGLKVVGG RRTDTGRLGA FITRVKPGSV ADTVGRLRAG DEVLEWNGQA LQNATFDQVY
EIISASKQDS HVEIIVSRSA SIPGGDDFLN VQTQSRQLPS LQYLLSQDNI RYNSPLLYVH
ICSSLSLSLG WSYMFTIVNQ YFTLFAIMGR CGIRFETLQF GQLNQALTRL CSLDSIMQAL
FKFNQPKYEC FKIDVSHLRM YLHAMPVVSL DYYLPQLMMG VNDW
//