ID A0A016WYQ9_9BILA Unreviewed; 420 AA.
AC A0A016WYQ9;
DT 11-JUN-2014, integrated into UniProtKB/TrEMBL.
DT 11-JUN-2014, sequence version 1.
DT 27-MAR-2024, entry version 30.
DE RecName: Full=Amiloride-sensitive sodium channel {ECO:0008006|Google:ProtNLM};
GN Name=Acey_s0452.g1696 {ECO:0000313|EMBL:EYC44721.1};
GN ORFNames=Y032_0452g1696 {ECO:0000313|EMBL:EYC44721.1};
OS Ancylostoma ceylanicum.
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Rhabditina; Rhabditomorpha; Strongyloidea; Ancylostomatidae;
OC Ancylostomatinae; Ancylostoma.
OX NCBI_TaxID=53326 {ECO:0000313|EMBL:EYC44721.1, ECO:0000313|Proteomes:UP000024635};
RN [1] {ECO:0000313|Proteomes:UP000024635}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=HY135 {ECO:0000313|Proteomes:UP000024635};
RX PubMed=25730766; DOI=10.1038/ng.3237;
RA Schwarz E.M., Hu Y., Antoshechkin I., Miller M.M., Sternberg P.W.,
RA Aroian R.V.;
RT "The genome and transcriptome of the zoonotic hookworm Ancylostoma
RT ceylanicum identify infection-specific gene families.";
RL Nat. Genet. 47:416-422(2015).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the amiloride-sensitive sodium channel (TC
CC 1.A.6) family. {ECO:0000256|ARBA:ARBA00007193,
CC ECO:0000256|RuleBase:RU000679}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:EYC44721.1}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; JARK01000052; EYC44721.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A016WYQ9; -.
DR Proteomes; UP000024635; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005272; F:sodium channel activity; IEA:UniProtKB-KW.
DR Gene3D; 1.10.287.770; YojJ-like; 1.
DR InterPro; IPR001873; ENaC.
DR PANTHER; PTHR11690; AMILORIDE-SENSITIVE SODIUM CHANNEL-RELATED; 1.
DR PANTHER; PTHR11690:SF232; DEGENERIN LIKE; 1.
DR Pfam; PF00858; ASC; 1.
DR PRINTS; PR01078; AMINACHANNEL.
PE 3: Inferred from homology;
KW Ion channel {ECO:0000256|RuleBase:RU000679};
KW Ion transport {ECO:0000256|RuleBase:RU000679};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000024635};
KW Sodium {ECO:0000256|ARBA:ARBA00023053};
KW Sodium channel {ECO:0000256|ARBA:ARBA00022461,
KW ECO:0000256|RuleBase:RU000679};
KW Sodium transport {ECO:0000256|ARBA:ARBA00023201,
KW ECO:0000256|RuleBase:RU000679};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW ECO:0000256|RuleBase:RU000679};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|RuleBase:RU000679}.
FT TRANSMEM 15..36
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
SQ SEQUENCE 420 AA; 49111 MW; FE46073BC7957184 CRC64;
MAWDDRKVVD ESQRLLWSCV ILVVVIISSY FMYHVLYDYF TNGTTTRLTV KQNATLLFPS
IHICPKNPDH LNYDVLFRDI TRRLGNLSME VKADILLYFI AGTGFQNTNV EEWSAVYRDS
VRKLVTRWMG ERSMLTMFKF VFDENGLQCS DILANCTPIS CCEYFRPYYV MSRGRCFRLD
NYYQKGGGSS HSLRLNFKHT KGLINGGAAQ KQVVVHFGDE YPDISKYPRI YITDNDYGTV
KFKLRKVSMM RMRENCTTDP LSRGRYTCYL SRWLQEKIIE PFNCTLPHLR NVTISRGYNI
CSPHVIVSHY GDIMSSATLK NKCILNCERW DLFFDLYTNW HRKDNAFRLD LSYRDLSYEE
YVEIEMLSLP SFISQIGGQL GLFLGTSIIS LIHLTCYLLT KITEVRLRVK ILVKDRSIDF
//
