ID A0A016WZ26_9BILA Unreviewed; 884 AA.
AC A0A016WZ26;
DT 11-JUN-2014, integrated into UniProtKB/TrEMBL.
DT 11-JUN-2014, sequence version 1.
DT 27-MAR-2024, entry version 35.
DE RecName: Full=Ionotropic glutamate receptor C-terminal domain-containing protein {ECO:0000259|SMART:SM00079};
GN Name=Acey_s0441.g1521 {ECO:0000313|EMBL:EYC45044.1};
GN Synonyms=Acey-nmr-1 {ECO:0000313|EMBL:EYC45044.1};
GN ORFNames=Y032_0441g1521 {ECO:0000313|EMBL:EYC45044.1};
OS Ancylostoma ceylanicum.
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Rhabditina; Rhabditomorpha; Strongyloidea; Ancylostomatidae;
OC Ancylostomatinae; Ancylostoma.
OX NCBI_TaxID=53326 {ECO:0000313|EMBL:EYC45044.1, ECO:0000313|Proteomes:UP000024635};
RN [1] {ECO:0000313|Proteomes:UP000024635}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=HY135 {ECO:0000313|Proteomes:UP000024635};
RX PubMed=25730766; DOI=10.1038/ng.3237;
RA Schwarz E.M., Hu Y., Antoshechkin I., Miller M.M., Sternberg P.W.,
RA Aroian R.V.;
RT "The genome and transcriptome of the zoonotic hookworm Ancylostoma
RT ceylanicum identify infection-specific gene families.";
RL Nat. Genet. 47:416-422(2015).
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004651};
CC Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004651}. Membrane
CC {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the glutamate-gated ion channel (TC 1.A.10.1)
CC family. {ECO:0000256|ARBA:ARBA00008685}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:EYC45044.1}.
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DR EMBL; JARK01000041; EYC45044.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A016WZ26; -.
DR Proteomes; UP000024635; Unassembled WGS sequence.
DR GO; GO:0017146; C:NMDA selective glutamate receptor complex; IEA:UniProt.
DR GO; GO:0045211; C:postsynaptic membrane; IEA:UniProtKB-KW.
DR GO; GO:0015276; F:ligand-gated monoatomic ion channel activity; IEA:InterPro.
DR GO; GO:0038023; F:signaling receptor activity; IEA:InterPro.
DR GO; GO:0007166; P:cell surface receptor signaling pathway; IEA:UniProt.
DR GO; GO:0042221; P:response to chemical; IEA:UniProt.
DR Gene3D; 1.10.287.70; -; 1.
DR Gene3D; 3.40.50.2300; -; 1.
DR Gene3D; 3.40.190.10; Periplasmic binding protein-like II; 2.
DR InterPro; IPR001828; ANF_lig-bd_rcpt.
DR InterPro; IPR001508; Iono_Glu_rcpt_met.
DR InterPro; IPR015683; Ionotropic_Glu_rcpt.
DR InterPro; IPR001320; Iontro_rcpt_C.
DR InterPro; IPR028082; Peripla_BP_I.
DR InterPro; IPR001638; Solute-binding_3/MltF_N.
DR PANTHER; PTHR18966:SF377; GLUTAMATE RECEPTOR IONOTROPIC, NMDA 1; 1.
DR PANTHER; PTHR18966; IONOTROPIC GLUTAMATE RECEPTOR; 1.
DR Pfam; PF01094; ANF_receptor; 1.
DR Pfam; PF00060; Lig_chan; 1.
DR Pfam; PF00497; SBP_bac_3; 1.
DR PRINTS; PR00177; NMDARECEPTOR.
DR SMART; SM00079; PBPe; 1.
DR SUPFAM; SSF53822; Periplasmic binding protein-like I; 1.
DR SUPFAM; SSF53850; Periplasmic binding protein-like II; 1.
PE 3: Inferred from homology;
KW Calcium {ECO:0000256|ARBA:ARBA00022837};
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Ion channel {ECO:0000256|ARBA:ARBA00023303};
KW Ion transport {ECO:0000256|ARBA:ARBA00023065};
KW Ligand-gated ion channel {ECO:0000256|ARBA:ARBA00023286};
KW Magnesium {ECO:0000256|ARBA:ARBA00022842};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Postsynaptic cell membrane {ECO:0000256|ARBA:ARBA00023257};
KW Receptor {ECO:0000256|ARBA:ARBA00023170};
KW Reference proteome {ECO:0000313|Proteomes:UP000024635};
KW Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|SAM:SignalP};
KW Synapse {ECO:0000256|ARBA:ARBA00023018};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|ARBA:ARBA00022448}.
FT SIGNAL 1..15
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 16..884
FT /note="Ionotropic glutamate receptor C-terminal domain-
FT containing protein"
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5013198199"
FT TRANSMEM 492..513
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 573..599
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 761..782
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 437..737
FT /note="Ionotropic glutamate receptor C-terminal"
FT /evidence="ECO:0000259|SMART:SM00079"
SQ SEQUENCE 884 AA; 99163 MW; BB9B19A220CD4CA0 CRC64;
MIILAVLLLA HSIPAKPILK IAVLIFGEHN FEDHVHSVKT AYWEIFETTS TQLANYTVVA
EYIDGGVLRK KPFNSANRLQ LTDEVVCEQV INRSIAVVIY APSLHRETQP EYLSRVSSTA
YALGFYSIPT IGVMVREAEF SKKKIYPTFV RPTPSYADES FVFLNLLRRL DYRQVVVVSV
KGDRNGEQFV ELFEKKRKKY KIHVQSYIEL EINDSLNTSL AVRFEEFTSN IVVLYATKPH
AIMIFSAAEV TGKQKVWIVN EDASKASNVP DGAIASRLSQ TPLSALRSSF ASIKSSLEFL
DSLDETVNPP SGCGKDAVHS KWATDHGLQL LRAICSTSTS KITFNERCER ISVDYDILNY
NEGYKEVGAL NGAHLRLAED SIHWTGGGRK PLEITLPKHL RAVTILDPPF IYTTPIISLA
ECKNLGTVSV ELSPVNIVQV EGPWYPCPKY GYNYTYHYCC AGYAIDLLSN LSLPEIPRDS
PMQSFLQPLK SALWTSLLIS VIMVGLVIFC LDLKSPFDRF YKMDKSQMAA DDPFLMEVAN
DRVNFGEAMW FVWGVLLNSG VSEKTPRSCA ARVLGIVWCG FCMIMVASYT ANLAAFLVLD
QPEKGLTGIT DPRLRNPSAN YSFGTVLNSN VYQYFKRHVE LSTMFRKMEA HNMEKVSDAV
ASLMNGSLDA FIWDSTRLDF EAARQCELRT RGALFGRSAY GVGLQKNSPW TPHITSAILR
MAESGIMEKL DAKWIDNKES KCVTEAHKSP ARLSLWNMKD VFILVTGGVA AGALCSTIEV
IYGRRKARRG RERALAARYV DKWRTIVHGG RMPSHYNLSR PVIRRGFAGL EPCTLADIRK
RELARSKQKI GDRVFLHPSP FVPDLNFGRH SVALFCSRCR VGVF
//
