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Database: UniProt
Entry: A0A016WZI4_9BILA
LinkDB: A0A016WZI4_9BILA
Original site: A0A016WZI4_9BILA 
ID   A0A016WZI4_9BILA        Unreviewed;       395 AA.
AC   A0A016WZI4;
DT   11-JUN-2014, integrated into UniProtKB/TrEMBL.
DT   11-JUN-2014, sequence version 1.
DT   03-JUL-2019, entry version 22.
DE   RecName: Full=Hyaluronidase {ECO:0000256|RuleBase:RU610713};
DE            EC=3.2.1.35 {ECO:0000256|RuleBase:RU610713};
DE   AltName: Full=Hyaluronoglucosaminidase {ECO:0000256|RuleBase:RU610713};
GN   Name=Acey_s0442.g1533 {ECO:0000313|EMBL:EYC45006.1};
GN   ORFNames=Y032_0442g1533 {ECO:0000313|EMBL:EYC45006.1};
OS   Ancylostoma ceylanicum.
OC   Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Strongylida;
OC   Ancylostomatoidea; Ancylostomatidae; Ancylostomatinae; Ancylostoma.
OX   NCBI_TaxID=53326 {ECO:0000313|EMBL:EYC45006.1, ECO:0000313|Proteomes:UP000024635};
RN   [1] {ECO:0000313|Proteomes:UP000024635}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=HY135 {ECO:0000313|Proteomes:UP000024635};
RX   PubMed=25730766; DOI=10.1038/ng.3237;
RA   Schwarz E.M., Hu Y., Antoshechkin I., Miller M.M., Sternberg P.W.,
RA   Aroian R.V.;
RT   "The genome and transcriptome of the zoonotic hookworm Ancylostoma
RT   ceylanicum identify infection-specific gene families.";
RL   Nat. Genet. 47:416-422(2015).
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=Random hydrolysis of (1->4)-linkages between N-acetyl-
CC         beta-D-glucosamine and D-glucuronate residues in hyaluronate.;
CC         EC=3.2.1.35; Evidence={ECO:0000256|RuleBase:RU610713};
CC   -!- SIMILARITY: Belongs to the glycosyl hydrolase 56 family.
CC       {ECO:0000256|PIRNR:PIRNR038193, ECO:0000256|RuleBase:RU610713}.
CC   -!- CAUTION: Lacks conserved residue(s) required for the propagation
CC       of feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00076}.
CC   -!- CAUTION: The sequence shown here is derived from an
CC       EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is
CC       preliminary data. {ECO:0000313|EMBL:EYC45006.1}.
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DR   EMBL; JARK01000042; EYC45006.1; -; Genomic_DNA.
DR   Proteomes; UP000024635; Unassembled WGS sequence.
DR   GO; GO:0004415; F:hyalurononglucosaminidase activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0005975; P:carbohydrate metabolic process; IEA:UniProtKB-UniRule.
DR   Gene3D; 3.20.20.70; -; 1.
DR   InterPro; IPR013785; Aldolase_TIM.
DR   InterPro; IPR013032; EGF-like_CS.
DR   InterPro; IPR000742; EGF-like_dom.
DR   InterPro; IPR017853; Glycoside_hydrolase_SF.
DR   InterPro; IPR018155; Hyaluronidase.
DR   PANTHER; PTHR11769; PTHR11769; 1.
DR   Pfam; PF01630; Glyco_hydro_56; 1.
DR   PIRSF; PIRSF038193; Hyaluronidase; 1.
DR   PRINTS; PR00846; GLHYDRLASE56.
DR   SUPFAM; SSF51445; SSF51445; 1.
DR   PROSITE; PS00022; EGF_1; 1.
DR   PROSITE; PS01186; EGF_2; 1.
DR   PROSITE; PS50026; EGF_3; 1.
PE   3: Inferred from homology;
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Complete proteome {ECO:0000313|Proteomes:UP000024635};
KW   Disulfide bond {ECO:0000256|PIRSR:PIRSR038193-3, ECO:0000256|PROSITE-
KW   ProRule:PRU00076};
KW   EGF-like domain {ECO:0000256|PROSITE-ProRule:PRU00076};
KW   Glycosidase {ECO:0000256|RuleBase:RU610713};
KW   Hydrolase {ECO:0000256|RuleBase:RU610713};
KW   Reference proteome {ECO:0000313|Proteomes:UP000024635};
KW   Signal {ECO:0000256|SAM:SignalP}.
FT   SIGNAL        1     16       {ECO:0000256|SAM:SignalP}.
FT   CHAIN        17    395       Hyaluronidase. {ECO:0000256|SAM:SignalP}.
FT                                /FTId=PRO_5001495213.
FT   DOMAIN      343    388       EGF-like. {ECO:0000259|PROSITE:PS50026}.
FT   COILED      148    168       {ECO:0000256|SAM:Coils}.
FT   ACT_SITE    116    116       Proton donor. {ECO:0000256|PIRSR:
FT                                PIRSR038193-1}.
FT   DISULFID     29    317       {ECO:0000256|PIRSR:PIRSR038193-3}.
FT   DISULFID    194    206       {ECO:0000256|PIRSR:PIRSR038193-3}.
FT   DISULFID    342    353       {ECO:0000256|PIRSR:PIRSR038193-3}.
FT   DISULFID    378    387       {ECO:0000256|PROSITE-ProRule:PRU00076}.
SQ   SEQUENCE   395 AA;  46121 MW;  B824F20D03D7F0C4 CRC64;
     MLFRTILFLI IPTLLGAFKA YWNFPSRTCR TNYSIKFEDY RIETNKNLSF YGEKVVIFYE
     FIFGNYPYYK NYKKDQPVNG GTPQNCSLEK HLEIARKNIT DLIPENFEGL AIIDLEEWRP
     LFDQNFWGLK SVFRNQSIAI VKEKNPNLEN ETEIAKLAEK EFNDAAKKFF VKTIQLGREL
     RPGAKWGFYG FPYCNYNAGK NGTYECWKKY QDWNDKMMFI FNESTALFPS IYLGSNATSD
     ERFRYVQAVL KEARRISEKF KPPLPIYAYT KIEYDPLREI DSFYNDHDLC STIKQPADLG
     IDGIIIWSSS RNMTLRCPHI KEKIEGSIGL KIRDTVSQHE NCRKQRCNDH GKCVLPKNST
     CSDHSSFLIN TEEYKCECDK GFTGEYCSPS DTTSK
//
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