ID A0A016X0N2_9BILA Unreviewed; 835 AA.
AC A0A016X0N2;
DT 11-JUN-2014, integrated into UniProtKB/TrEMBL.
DT 11-JUN-2014, sequence version 1.
DT 27-MAR-2024, entry version 35.
DE RecName: Full=LITAF domain-containing protein {ECO:0000259|PROSITE:PS51837};
GN Name=Acey_s0441.g1521 {ECO:0000313|EMBL:EYC45042.1};
GN Synonyms=Acey-nmr-1 {ECO:0000313|EMBL:EYC45042.1};
GN ORFNames=Y032_0441g1521 {ECO:0000313|EMBL:EYC45042.1};
OS Ancylostoma ceylanicum.
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Rhabditina; Rhabditomorpha; Strongyloidea; Ancylostomatidae;
OC Ancylostomatinae; Ancylostoma.
OX NCBI_TaxID=53326 {ECO:0000313|EMBL:EYC45042.1, ECO:0000313|Proteomes:UP000024635};
RN [1] {ECO:0000313|Proteomes:UP000024635}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=HY135 {ECO:0000313|Proteomes:UP000024635};
RX PubMed=25730766; DOI=10.1038/ng.3237;
RA Schwarz E.M., Hu Y., Antoshechkin I., Miller M.M., Sternberg P.W.,
RA Aroian R.V.;
RT "The genome and transcriptome of the zoonotic hookworm Ancylostoma
RT ceylanicum identify infection-specific gene families.";
RL Nat. Genet. 47:416-422(2015).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the glutamate-gated ion channel (TC 1.A.10.1)
CC family. {ECO:0000256|ARBA:ARBA00008685}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:EYC45042.1}.
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DR EMBL; JARK01000041; EYC45042.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A016X0N2; -.
DR Proteomes; UP000024635; Unassembled WGS sequence.
DR GO; GO:0045211; C:postsynaptic membrane; IEA:UniProtKB-KW.
DR GO; GO:0015276; F:ligand-gated monoatomic ion channel activity; IEA:InterPro.
DR GO; GO:0007166; P:cell surface receptor signaling pathway; IEA:UniProt.
DR Gene3D; 1.10.287.70; -; 1.
DR Gene3D; 3.40.50.2300; -; 1.
DR Gene3D; 3.40.190.10; Periplasmic binding protein-like II; 1.
DR InterPro; IPR001828; ANF_lig-bd_rcpt.
DR InterPro; IPR015683; Ionotropic_Glu_rcpt.
DR InterPro; IPR001320; Iontro_rcpt_C.
DR InterPro; IPR006629; LITAF.
DR InterPro; IPR028082; Peripla_BP_I.
DR InterPro; IPR001638; Solute-binding_3/MltF_N.
DR PANTHER; PTHR18966:SF377; GLUTAMATE RECEPTOR IONOTROPIC, NMDA 1; 1.
DR PANTHER; PTHR18966; IONOTROPIC GLUTAMATE RECEPTOR; 1.
DR Pfam; PF01094; ANF_receptor; 1.
DR Pfam; PF00060; Lig_chan; 1.
DR Pfam; PF00497; SBP_bac_3; 1.
DR Pfam; PF10601; zf-LITAF-like; 1.
DR SMART; SM00714; LITAF; 1.
DR SMART; SM00079; PBPe; 1.
DR SUPFAM; SSF53822; Periplasmic binding protein-like I; 1.
DR SUPFAM; SSF53850; Periplasmic binding protein-like II; 1.
DR PROSITE; PS51837; LITAF; 1.
PE 3: Inferred from homology;
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Ion channel {ECO:0000256|ARBA:ARBA00023303};
KW Ion transport {ECO:0000256|ARBA:ARBA00023065};
KW Ligand-gated ion channel {ECO:0000256|ARBA:ARBA00023286};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Postsynaptic cell membrane {ECO:0000256|ARBA:ARBA00023257};
KW Receptor {ECO:0000256|ARBA:ARBA00023170};
KW Reference proteome {ECO:0000313|Proteomes:UP000024635};
KW Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|SAM:SignalP};
KW Synapse {ECO:0000256|ARBA:ARBA00023018};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|ARBA:ARBA00022448}.
FT SIGNAL 1..15
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 16..835
FT /note="LITAF domain-containing protein"
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5012497681"
FT TRANSMEM 457..478
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 538..564
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 781..798
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 744..827
FT /note="LITAF"
FT /evidence="ECO:0000259|PROSITE:PS51837"
SQ SEQUENCE 835 AA; 94202 MW; 964C9894DFA2FBEC CRC64;
MIILAVLLLA HSIPAKPILK IAVLIFGEHN FEDHVHSVKT AYWEIFETTS TQLANYTVVA
EYIDGGVLRK KPFNSANRLQ LTDEVVCEQV INRSIAVVIY APSLHRETQP EYLSRVSSTA
YALGFYSIPT IGVMVREAEF SKKKIYPTFV RPTPSYADES FVFLNLLRRL DYRQVVVVSV
KGDRNGEQFV ELFEKKRKKY KIHVQSYIEL EINDSLNTSL AVRFEEFTSN IVVLYATKPH
AIMIFSAAEV TGKQKVWIVN EDASKASNVP DGAIASRLSQ TPLSALRSSF ASIKSSLEFL
DSLDETVNPP SGCGKDAVHS KWATDHGLQL LRAICSTSTS KITFNERCER ISVDYDILNY
NEGYKEVGAL NGAHLRLAED SIHWTGGGRK PLEITLPKHL RAVTILDPPF IYTTPIISLA
ECKNLGTVSV ELSPVNIVQV IPRDSPMQSF LQPLKSALWT SLLISVIMVG LVIFCLDLKS
PFDRFYKMDK SQMAADDPFL MEVANDRVNF GEAMWFVWGV LLNSGVSEKT PRSCAARVLG
IVWCGFCMIM VASYTANLAA FLVLDQPEKG LTGITDPRLR NPSANYSFGT VLNSNVYQYF
KRHVELSTMF RKMEAHNMEK VSDAVASLMN GSLDAFIWDS TRLDFEAARQ CELRTRGALF
GRSAYGVGLQ KNSPWTPHIT SAILRMAESG IMEKLDAKWI DNKESKCVTE AHKSPARLSL
WNMKDIRKRE LARSKQKIGD RVFLHPSPFV PDLNFGRHSV ALFCSRCRNL VETDVHRECG
LFAYVWCVIF VLLFLWPCSP LPCFMEAFAD FVHICPVCSH KIGRYRRCRR PKFYV
//