ID A0A016X156_9BILA Unreviewed; 1148 AA.
AC A0A016X156;
DT 11-JUN-2014, integrated into UniProtKB/TrEMBL.
DT 11-JUN-2014, sequence version 1.
DT 27-MAR-2024, entry version 31.
DE RecName: Full=THUMP domain-containing protein {ECO:0000259|PROSITE:PS51165};
GN Name=Acey_s0416.g1087 {ECO:0000313|EMBL:EYC45814.1};
GN Synonyms=Acey-mep-1 {ECO:0000313|EMBL:EYC45814.1};
GN ORFNames=Y032_0416g1087 {ECO:0000313|EMBL:EYC45814.1};
OS Ancylostoma ceylanicum.
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Rhabditina; Rhabditomorpha; Strongyloidea; Ancylostomatidae;
OC Ancylostomatinae; Ancylostoma.
OX NCBI_TaxID=53326 {ECO:0000313|EMBL:EYC45814.1, ECO:0000313|Proteomes:UP000024635};
RN [1] {ECO:0000313|Proteomes:UP000024635}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=HY135 {ECO:0000313|Proteomes:UP000024635};
RX PubMed=25730766; DOI=10.1038/ng.3237;
RA Schwarz E.M., Hu Y., Antoshechkin I., Miller M.M., Sternberg P.W.,
RA Aroian R.V.;
RT "The genome and transcriptome of the zoonotic hookworm Ancylostoma
RT ceylanicum identify infection-specific gene families.";
RL Nat. Genet. 47:416-422(2015).
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:EYC45814.1}.
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DR EMBL; JARK01000016; EYC45814.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A016X156; -.
DR STRING; 53326.A0A016X156; -.
DR Proteomes; UP000024635; Unassembled WGS sequence.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0008168; F:methyltransferase activity; IEA:UniProtKB-KW.
DR GO; GO:0003723; F:RNA binding; IEA:UniProtKB-UniRule.
DR GO; GO:0032259; P:methylation; IEA:UniProtKB-KW.
DR GO; GO:0009451; P:RNA modification; IEA:UniProt.
DR GO; GO:0008033; P:tRNA processing; IEA:UniProtKB-KW.
DR CDD; cd02440; AdoMet_MTases; 1.
DR CDD; cd11715; THUMP_AdoMetMT; 1.
DR Gene3D; 3.30.2130.30; -; 1.
DR Gene3D; 3.40.50.150; Vaccinia Virus protein VP39; 1.
DR InterPro; IPR000241; RlmKL-like_Mtase.
DR InterPro; IPR029063; SAM-dependent_MTases_sf.
DR InterPro; IPR004114; THUMP_dom.
DR InterPro; IPR013087; Znf_C2H2_type.
DR PANTHER; PTHR14911; THUMP DOMAIN-CONTAINING; 1.
DR PANTHER; PTHR14911:SF13; TRNA (GUANINE(6)-N2)-METHYLTRANSFERASE THUMP3; 1.
DR Pfam; PF02926; THUMP; 1.
DR Pfam; PF01170; UPF0020; 1.
DR SMART; SM00981; THUMP; 1.
DR SMART; SM00355; ZnF_C2H2; 7.
DR SUPFAM; SSF53335; S-adenosyl-L-methionine-dependent methyltransferases; 1.
DR SUPFAM; SSF143437; THUMP domain-like; 1.
DR PROSITE; PS51165; THUMP; 1.
DR PROSITE; PS00028; ZINC_FINGER_C2H2_1; 3.
PE 4: Predicted;
KW Methyltransferase {ECO:0000256|ARBA:ARBA00022603};
KW Reference proteome {ECO:0000313|Proteomes:UP000024635};
KW RNA-binding {ECO:0000256|PROSITE-ProRule:PRU00529};
KW Transferase {ECO:0000256|ARBA:ARBA00022603}.
FT DOMAIN 870..983
FT /note="THUMP"
FT /evidence="ECO:0000259|PROSITE:PS51165"
FT REGION 1..140
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 53..87
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 96..138
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1148 AA; 126795 MW; DECB9AFF3B1A03E7 CRC64;
MVSTMDEPVP TVQAPEESTD QDDQIQKLKA ENRLAASEGD ANGEDSTMGV DDKENGDSTS
SPAVNAPTTS EDVSAAATTN GSSTPNEVEC IELDDDSSEP PAKKAKASDS NDSDIAVING
KDEKSPAKDE KPKEKEAELT SPGALLNKLE EYVSDAIDNK KNIDRKVLDA LLGAINVQVQ
KEPLSVRKLI LDKQLVLPNT ISFPPSLTVD MLIEHDPDHP LSKVITRMFG EERPKLNEAE
KKERQTLKLH NNAPHMTKLL LDIGQDLVQE STYCDIVHAR NLPETPKNIE TYKQVAAQLK
PVWEALRKRN EPYKLKMLSC QVCGFKTESR MVLQAHRSTV HFKNGKYQCA MCPEFDTNEQ
RLINHYLESH LIIASKEEPQ GKYPCLICDE DFQYKGLRDT HLRTCKKDYS RVRNIMGPKG
PDDQLMINRW LWDRPPIDPT ILQQQQAAQA QQVRRSSAAF PDKRNQLAQA QQAVAQAALR
RTAAVRDAQQ NALQQQLLQQ QQRMRQAAAM MQQRNMLGQN SNSLIAAMQQ HIQRASQQRG
STTAAATVGS LAAATALYQK NLAASRNALL ANASALRKGP TMNAAAMQKA FALANGGLST
AAASGAASST AGTHALGNST NAGNGPGICE ICDQNMVDRE RYFQHLQLIH KHLRDKTLDD
VKLGAPLACS RCRERFWTYE GLERHLVMAH GLVTADLLTK AQNKLDGGRC KLCAKQYAFN
MLQHLVADHH IKLCSAEIMY SCDVCSFKCS SYTTLESHLN ANHPKGVTDK NAVAPASGET
ASASNGTSKM IELYASVITG FESVSSEEVA TTFASDAIRG RGYVRFEVDP SKIPEALHLR
SIDNLFAMLY DYELEGLTTA SQEEALQKIK GEISRINWKT AIDCWQIATG KQVPGGIETV
KEQMREFARN GVTGLTPQNS FTFRVTCNRA GEKSRHSFSS MDAAKALGAQ INNIFGWRPD
MKNFDMEVVL NIRNDTMLVM VALNKESLFK RNVCAFGPTT MRSTMCYCMT ALAHPSRGDV
ILDPMCGGGS IPLEAALAFP GCLFFGADLH PKALERCYEN LENCKEQLLR CGSDVSFLSC
DAVDLPFRDS LVDAIVTDLP FGKKIGSVDD NRILYPRLLM EWERVVKPGG RLVVMTHDKR
SWVKNALQ
//
