ID A0A017H289_9FUSO Unreviewed; 277 AA.
AC A0A017H289;
DT 11-JUN-2014, integrated into UniProtKB/TrEMBL.
DT 11-JUN-2014, sequence version 1.
DT 27-MAR-2024, entry version 41.
DE SubName: Full=3-hydroxybutyryl-CoA dehydrogenase {ECO:0000313|EMBL:KID50307.1};
DE EC=1.1.1.157 {ECO:0000313|EMBL:KID50307.1};
GN ORFNames=C095_00355 {ECO:0000313|EMBL:KID50307.1};
OS Fusobacterium necrophorum subsp. funduliforme B35.
OC Bacteria; Fusobacteriota; Fusobacteriia; Fusobacteriales; Fusobacteriaceae;
OC Fusobacterium.
OX NCBI_TaxID=1226633 {ECO:0000313|EMBL:KID50307.1, ECO:0000313|Proteomes:UP000031184};
RN [1] {ECO:0000313|EMBL:KID50307.1, ECO:0000313|Proteomes:UP000031184}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=B35 {ECO:0000313|EMBL:KID50307.1,
RC ECO:0000313|Proteomes:UP000031184};
RA Benahmed F.H., Rasmussen M., Harbottle H., Soppet D., Nagaraja T.G.,
RA Davidson M.;
RT "An opportunistic ruminal bacterium that causes liver abscesses in
RT cattle.";
RL Submitted (AUG-2013) to the EMBL/GenBank/DDBJ databases.
CC -!- PATHWAY: Lipid metabolism; butanoate metabolism.
CC {ECO:0000256|ARBA:ARBA00005086}.
CC -!- SIMILARITY: Belongs to the 3-hydroxyacyl-CoA dehydrogenase family.
CC {ECO:0000256|ARBA:ARBA00009463}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KID50307.1}.
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DR EMBL; AUZI01000005; KID50307.1; -; Genomic_DNA.
DR RefSeq; WP_005958146.1; NZ_AOJP01000020.1.
DR AlphaFoldDB; A0A017H289; -.
DR PATRIC; fig|1226633.4.peg.63; -.
DR OrthoDB; 9771883at2; -.
DR Proteomes; UP000031184; Unassembled WGS sequence.
DR GO; GO:0008691; F:3-hydroxybutyryl-CoA dehydrogenase activity; IEA:UniProtKB-EC.
DR GO; GO:0070403; F:NAD+ binding; IEA:InterPro.
DR GO; GO:0044248; P:cellular catabolic process; IEA:UniProt.
DR GO; GO:0006631; P:fatty acid metabolic process; IEA:InterPro.
DR GO; GO:1901575; P:organic substance catabolic process; IEA:UniProt.
DR Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 1.
DR InterPro; IPR022694; 3-OHacyl-CoA_DH.
DR InterPro; IPR006180; 3-OHacyl-CoA_DH_CS.
DR InterPro; IPR006176; 3-OHacyl-CoA_DH_NAD-bd.
DR InterPro; IPR006108; 3HC_DH_C.
DR InterPro; IPR008927; 6-PGluconate_DH-like_C_sf.
DR InterPro; IPR013328; 6PGD_dom2.
DR InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR PANTHER; PTHR48075; 3-HYDROXYACYL-COA DEHYDROGENASE FAMILY PROTEIN; 1.
DR PANTHER; PTHR48075:SF5; 3-HYDROXYACYL-COA DEHYDROGENASE FAMILY PROTEIN; 1.
DR Pfam; PF00725; 3HCDH; 1.
DR Pfam; PF02737; 3HCDH_N; 1.
DR PIRSF; PIRSF000105; HCDH; 1.
DR SUPFAM; SSF48179; 6-phosphogluconate dehydrogenase C-terminal domain-like; 1.
DR SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 1.
DR PROSITE; PS00067; 3HCDH; 1.
PE 3: Inferred from homology;
KW Oxidoreductase {ECO:0000256|ARBA:ARBA00023002,
KW ECO:0000313|EMBL:KID50307.1}.
FT DOMAIN 2..178
FT /note="3-hydroxyacyl-CoA dehydrogenase NAD binding"
FT /evidence="ECO:0000259|Pfam:PF02737"
FT DOMAIN 181..277
FT /note="3-hydroxyacyl-CoA dehydrogenase C-terminal"
FT /evidence="ECO:0000259|Pfam:PF00725"
SQ SEQUENCE 277 AA; 29685 MW; 1B5AE2057D5D0BF0 CRC64;
MKVGVIGAGT MGSGIAQAFA QAEGYEVVLC DINDEFAARG KEKLKKGFDK RIAKGKMEQA
VADSILSKIT TGTKEKCGDC DLIIEAAVEN MEIKKQTFKE LQAICKPEAI FATNTSSLSI
TEIGAGLDRP VIGMHFFNPA PVMKLVEVIA GLNTPVEMVD TIKKVSEEIG KVPVQVEEAA
GFVVNRVLIP MINEAVGIYA DGVASVEGID AAMKLGANHP MGPLALGDLI GLDVCLAIME
VLYKEFGDTK YRPHPLLRKM VRGGKLGMKS GEGFYKY
//
