ID A0A021VP33_9CELL Unreviewed; 541 AA.
AC A0A021VP33;
DT 11-JUN-2014, integrated into UniProtKB/TrEMBL.
DT 11-JUN-2014, sequence version 1.
DT 27-MAR-2024, entry version 29.
DE SubName: Full=3'-5' exonuclease {ECO:0000313|EMBL:EYR62863.1};
DE Flags: Fragment;
GN ORFNames=N866_04625 {ECO:0000313|EMBL:EYR62863.1};
OS Actinotalea ferrariae CF5-4.
OC Bacteria; Actinomycetota; Actinomycetes; Micrococcales; Cellulomonadaceae;
OC Actinotalea.
OX NCBI_TaxID=948458 {ECO:0000313|EMBL:EYR62863.1, ECO:0000313|Proteomes:UP000019753};
RN [1] {ECO:0000313|EMBL:EYR62863.1, ECO:0000313|Proteomes:UP000019753}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CF5-4 {ECO:0000313|EMBL:EYR62863.1,
RC ECO:0000313|Proteomes:UP000019753};
RA Chen F., Li Y., Wang G.;
RT "Actinotalea ferrariae CF5-4.";
RL Submitted (JAN-2014) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=a 2'-deoxyribonucleoside 5'-triphosphate + DNA(n) =
CC diphosphate + DNA(n+1); Xref=Rhea:RHEA:22508, Rhea:RHEA-COMP:17339,
CC Rhea:RHEA-COMP:17340, ChEBI:CHEBI:33019, ChEBI:CHEBI:61560,
CC ChEBI:CHEBI:173112; EC=2.7.7.7;
CC Evidence={ECO:0000256|ARBA:ARBA00024632};
CC -!- SIMILARITY: Belongs to the DNA polymerase type-A family.
CC {ECO:0000256|ARBA:ARBA00007705}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:EYR62863.1}.
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DR EMBL; AXCW01000157; EYR62863.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A021VP33; -.
DR OrthoDB; 4414061at2; -.
DR Proteomes; UP000019753; Unassembled WGS sequence.
DR GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR GO; GO:0003887; F:DNA-directed DNA polymerase activity; IEA:InterPro.
DR GO; GO:0004527; F:exonuclease activity; IEA:UniProtKB-KW.
DR GO; GO:0006261; P:DNA-templated DNA replication; IEA:InterPro.
DR CDD; cd06444; DNA_pol_A; 1.
DR Gene3D; 3.30.70.370; -; 1.
DR Gene3D; 1.10.150.20; 5' to 3' exonuclease, C-terminal subdomain; 1.
DR InterPro; IPR001098; DNA-dir_DNA_pol_A_palm_dom.
DR InterPro; IPR043502; DNA/RNA_pol_sf.
DR InterPro; IPR002298; DNA_polymerase_A.
DR PANTHER; PTHR10133; DNA POLYMERASE I; 1.
DR PANTHER; PTHR10133:SF62; DNA POLYMERASE THETA; 1.
DR Pfam; PF00476; DNA_pol_A; 1.
DR SMART; SM00482; POLAc; 1.
DR SUPFAM; SSF56672; DNA/RNA polymerases; 1.
PE 3: Inferred from homology;
KW Exonuclease {ECO:0000313|EMBL:EYR62863.1};
KW Hydrolase {ECO:0000313|EMBL:EYR62863.1};
KW Nuclease {ECO:0000313|EMBL:EYR62863.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000019753}.
FT DOMAIN 287..500
FT /note="DNA-directed DNA polymerase family A palm"
FT /evidence="ECO:0000259|SMART:SM00482"
FT REGION 409..432
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT NON_TER 1
FT /evidence="ECO:0000313|EMBL:EYR62863.1"
SQ SEQUENCE 541 AA; 57740 MW; B26C578F93B029B7 CRC64;
TVVPAADLPG VVARREAAAA PRWVWDDTAR RYPALLAAGV RVRRCHDLRL VHAILRRSER
CAGSVLARAE PGSWDTPSAV VPDADDAPAS LFDDPGLDDP GHGDGPDCLT ELREQLAAVA
GADEPGRLRL LVAAESTGAL VAAEMHHDGL PWSTAAHDAL LEELLGPRPR AGERPARLEA
LAARVRSLLD QPGLNLDSQP DLLRALRRAG LEVTSTRRHE IAALRHAVVE PLLEYRTLAR
LLSTNGWAWR EQWVHDGRFR PDYVPGGVVT GRWASSGGGA LQLPAVVRSA VRADPGWRLV
VADAAQLEPR VLAAMAGDLA MAAAGRQADL YAGVVDSGAV HTREEAKYAM LGAIYGATTG
AGGVLMPRLT RAFPRAIGLV EEAARAGERG EVVSTWLGRT CPPPGGAWRA SVGDASVEGA
GPEAAREAQR RRRDRGRFTR NFVVQGTAAE WALCWIAALR RRLLDLPPPA GTAPQRGRNP
RPHLVLFLHD EVVVHTPEEL AGDVAAAVRD AATEAGRLLF GSFPVEFALD VAVVEAYDQA
G
//
