ID A0A022KVF9_9ACTN Unreviewed; 298 AA.
AC A0A022KVF9;
DT 11-JUN-2014, integrated into UniProtKB/TrEMBL.
DT 11-JUN-2014, sequence version 1.
DT 27-MAR-2024, entry version 44.
DE RecName: Full=site-specific DNA-methyltransferase (adenine-specific) {ECO:0000256|ARBA:ARBA00011900};
DE EC=2.1.1.72 {ECO:0000256|ARBA:ARBA00011900};
DE Flags: Fragment;
GN ORFNames=H483_0118525 {ECO:0000313|EMBL:EYT48642.1};
OS Dietzia sp. UCD-THP.
OC Bacteria; Actinomycetota; Actinomycetes; Mycobacteriales; Dietziaceae;
OC Dietzia.
OX NCBI_TaxID=1292020 {ECO:0000313|EMBL:EYT48642.1, ECO:0000313|Proteomes:UP000019757};
RN [1] {ECO:0000313|EMBL:EYT48642.1, ECO:0000313|Proteomes:UP000019757}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=UCD-THP {ECO:0000313|EMBL:EYT48642.1,
RC ECO:0000313|Proteomes:UP000019757};
RX PubMed=23661480;
RA Diep A.L., Lang J.M., Darling A.E., Eisen J.A., Coil D.A.;
RT "Draft Genome Sequence of Dietzia sp. Strain UCD-THP (Phylum
RT Actinobacteria).";
RL Genome Announc. 1:E00197-E00113(2013).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=a 2'-deoxyadenosine in DNA + S-adenosyl-L-methionine = an
CC N(6)-methyl-2'-deoxyadenosine in DNA + H(+) + S-adenosyl-L-
CC homocysteine; Xref=Rhea:RHEA:15197, Rhea:RHEA-COMP:12418, Rhea:RHEA-
CC COMP:12419, ChEBI:CHEBI:15378, ChEBI:CHEBI:57856, ChEBI:CHEBI:59789,
CC ChEBI:CHEBI:90615, ChEBI:CHEBI:90616; EC=2.1.1.72;
CC Evidence={ECO:0000256|ARBA:ARBA00001279};
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:EYT48642.1}.
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DR EMBL; AOSR01000171; EYT48642.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A022KVF9; -.
DR eggNOG; COG0286; Bacteria.
DR HOGENOM; CLU_935393_0_0_11; -.
DR Proteomes; UP000019757; Unassembled WGS sequence.
DR GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR GO; GO:0004519; F:endonuclease activity; IEA:UniProtKB-KW.
DR GO; GO:0008170; F:N-methyltransferase activity; IEA:InterPro.
DR GO; GO:0006306; P:DNA methylation; IEA:InterPro.
DR Gene3D; 3.40.50.150; Vaccinia Virus protein VP39; 1.
DR InterPro; IPR003356; DNA_methylase_A-5.
DR InterPro; IPR029063; SAM-dependent_MTases_sf.
DR PANTHER; PTHR42933:SF1; SITE-SPECIFIC DNA-METHYLTRANSFERASE (ADENINE-SPECIFIC); 1.
DR PANTHER; PTHR42933; SLR6095 PROTEIN; 1.
DR Pfam; PF02384; N6_Mtase; 1.
DR PRINTS; PR00507; N12N6MTFRASE.
DR SUPFAM; SSF53335; S-adenosyl-L-methionine-dependent methyltransferases; 1.
PE 4: Predicted;
KW Endonuclease {ECO:0000313|EMBL:EYT48642.1};
KW Hydrolase {ECO:0000313|EMBL:EYT48642.1};
KW Methyltransferase {ECO:0000256|ARBA:ARBA00022603};
KW Nuclease {ECO:0000313|EMBL:EYT48642.1};
KW Restriction system {ECO:0000256|ARBA:ARBA00022747};
KW S-adenosyl-L-methionine {ECO:0000256|ARBA:ARBA00022691};
KW Transferase {ECO:0000256|ARBA:ARBA00022679}.
FT DOMAIN 4..235
FT /note="DNA methylase adenine-specific"
FT /evidence="ECO:0000259|Pfam:PF02384"
FT NON_TER 1
FT /evidence="ECO:0000313|EMBL:EYT48642.1"
FT NON_TER 298
FT /evidence="ECO:0000313|EMBL:EYT48642.1"
SQ SEQUENCE 298 AA; 33153 MW; BA540E268F0BF137 CRC64;
NALGIVLTPH HITDLMAELI DVDADDFVID PCAGTAGFLI AAMRRMFDDV DRRYGDRAGV
LATKQREIRE HRLHGVELQD KLFAIGTTNM ILRGDGKANF RRHSIFDLST EELRGEHGFT
KALINPPYSQ AKTKETRHLS ELSFIERALS LLNHKGRLAA IVPQSSMVGK TKEDKARKGR
ILAGHTLDAV ITMNPDTFYG VGTNVVIAMF TAGVPHPASK KTAFVNFKDD GYKVRQHLGL
MGDGNEKSRR AHLLSVLNDG VADDTSFIVR SEIAATDEWQ HAFFYFTDQP PTYEDFLG
//
