ID A0A022M8B2_9ACTN Unreviewed; 627 AA.
AC A0A022M8B2;
DT 11-JUN-2014, integrated into UniProtKB/TrEMBL.
DT 11-JUN-2014, sequence version 1.
DT 27-MAR-2024, entry version 30.
DE RecName: Full=cellulose synthase (UDP-forming) {ECO:0000256|ARBA:ARBA00012539};
DE EC=2.4.1.12 {ECO:0000256|ARBA:ARBA00012539};
GN ORFNames=CF54_38710 {ECO:0000313|EMBL:EYT78184.1};
OS Streptomyces sp. Tu 6176.
OC Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
OC Streptomycetaceae; Streptomyces.
OX NCBI_TaxID=1470557 {ECO:0000313|EMBL:EYT78184.1, ECO:0000313|Proteomes:UP000020060};
RN [1] {ECO:0000313|EMBL:EYT78184.1, ECO:0000313|Proteomes:UP000020060}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Tu 6176 {ECO:0000313|EMBL:EYT78184.1,
RC ECO:0000313|Proteomes:UP000020060};
RA Olano C., Cano-Prieto C., Mendez C., Salas J.A.;
RT "Draft genome sequence of Streptomyces sp. Tu 6176, producer of the
RT cytotoxic benzoxazol nataxazol.";
RL Submitted (MAR-2014) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:EYT78184.1}.
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DR EMBL; JFJQ01001213; EYT78184.1; -; Genomic_DNA.
DR RefSeq; WP_037896867.1; NZ_KK106996.1.
DR AlphaFoldDB; A0A022M8B2; -.
DR HOGENOM; CLU_032986_0_0_11; -.
DR OrthoDB; 9806824at2; -.
DR Proteomes; UP000020060; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0016757; F:glycosyltransferase activity; IEA:UniProtKB-KW.
DR GO; GO:0030244; P:cellulose biosynthetic process; IEA:UniProtKB-KW.
DR CDD; cd06421; CESA_CelA_like; 1.
DR InterPro; IPR001173; Glyco_trans_2-like.
DR InterPro; IPR029044; Nucleotide-diphossugar_trans.
DR PANTHER; PTHR43867; CELLULOSE SYNTHASE CATALYTIC SUBUNIT A [UDP-FORMING]; 1.
DR PANTHER; PTHR43867:SF2; CELLULOSE SYNTHASE CATALYTIC SUBUNIT A [UDP-FORMING]; 1.
DR Pfam; PF13632; Glyco_trans_2_3; 1.
DR SUPFAM; SSF53448; Nucleotide-diphospho-sugar transferases; 1.
PE 4: Predicted;
KW Cellulose biosynthesis {ECO:0000256|ARBA:ARBA00022916};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Transferase {ECO:0000256|ARBA:ARBA00022679, ECO:0000313|EMBL:EYT78184.1};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 66..87
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 99..120
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 409..437
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 449..469
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 533..550
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 557..575
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 247..437
FT /note="Glycosyltransferase 2-like"
FT /evidence="ECO:0000259|Pfam:PF13632"
FT REGION 580..627
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 627 AA; 68842 MW; E9EC287039D27E25 CRC64;
MTSTPPPGAR HRSGSTTGAF RTIRSALPRY DYEHHSRLAG PLTRPDPDRP YRVRHRSLLA
QEPHRVRVTL MLVAAPLLSL VLLAWLMQPA HWTERDHPAH PWLPFLDAVM LVSIGLIELF
RCLNVLSNAH ATLVARDPVP VVPESGTRVA FLTTFVPGKE PLELAARTLR AAVRLRHRGV
MHVWLLDEGD DPEAKALCAR LGVHHFTRRG VERWNRPSGP HRARTKHGNY NAWLQAHGGA
YDVFASVDTD HVPLPNYLER MLGYFRDPDV GFVVGPQVYG NYDTFVTKAA ESQQFLFHAL
IQRAGNRYGA PMFVGTCNAV RISALKQIGG LHDSITEDMA TGFEMHRARN PATGRRWKSV
YTPDVLAVGE GPASWTDFFS QQLRWSRGTY ETILTQYWKG FGSLPPGRLL NYTLLIAFYP
LSALNWILAA LSCALFLGLG ASGVNIDPVV WLMLYGNASA LQIGLYLWNR RHNVSPHEPE
GSGGVAGMVM SALSAPVYAR ALLDAVLRRP SRFVVTPKGA AHSPDTPFGT FRVHWFFVLV
FGGSIAAGIV RGHSHPAMLT WAGLALLITL SPVAVRLCSP RRPGTGPGRE AHPANPTTPA
NPANPVPSAR DAAPRAYAGH GTGGREA
//
