ID A0A022MG28_9ACTN Unreviewed; 487 AA.
AC A0A022MG28;
DT 11-JUN-2014, integrated into UniProtKB/TrEMBL.
DT 11-JUN-2014, sequence version 1.
DT 24-JAN-2024, entry version 33.
DE SubName: Full=Betaine-aldehyde dehydrogenase {ECO:0000313|EMBL:EYT79690.1};
GN ORFNames=CF54_29835 {ECO:0000313|EMBL:EYT79690.1};
OS Streptomyces sp. Tu 6176.
OC Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
OC Streptomycetaceae; Streptomyces.
OX NCBI_TaxID=1470557 {ECO:0000313|EMBL:EYT79690.1, ECO:0000313|Proteomes:UP000020060};
RN [1] {ECO:0000313|EMBL:EYT79690.1, ECO:0000313|Proteomes:UP000020060}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Tu 6176 {ECO:0000313|EMBL:EYT79690.1,
RC ECO:0000313|Proteomes:UP000020060};
RA Olano C., Cano-Prieto C., Mendez C., Salas J.A.;
RT "Draft genome sequence of Streptomyces sp. Tu 6176, producer of the
RT cytotoxic benzoxazol nataxazol.";
RL Submitted (MAR-2014) to the EMBL/GenBank/DDBJ databases.
CC -!- SIMILARITY: Belongs to the aldehyde dehydrogenase family.
CC {ECO:0000256|RuleBase:RU003345}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:EYT79690.1}.
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DR EMBL; JFJQ01000939; EYT79690.1; -; Genomic_DNA.
DR RefSeq; WP_037895011.1; NZ_KK106992.1.
DR AlphaFoldDB; A0A022MG28; -.
DR HOGENOM; CLU_005391_0_2_11; -.
DR OrthoDB; 6882680at2; -.
DR Proteomes; UP000020060; Unassembled WGS sequence.
DR GO; GO:0016620; F:oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor; IEA:InterPro.
DR CDD; cd07093; ALDH_F8_HMSADH; 1.
DR InterPro; IPR016161; Ald_DH/histidinol_DH.
DR InterPro; IPR016163; Ald_DH_C.
DR InterPro; IPR016160; Ald_DH_CS_CYS.
DR InterPro; IPR029510; Ald_DH_CS_GLU.
DR InterPro; IPR016162; Ald_DH_N.
DR InterPro; IPR015590; Aldehyde_DH_dom.
DR PANTHER; PTHR11699:SF211; ALDEHYDE DEHYDROGENASE FAMILY 16 MEMBER A1; 1.
DR PANTHER; PTHR11699; ALDEHYDE DEHYDROGENASE-RELATED; 1.
DR Pfam; PF00171; Aldedh; 1.
DR SUPFAM; SSF53720; ALDH-like; 1.
DR PROSITE; PS00070; ALDEHYDE_DEHYDR_CYS; 1.
DR PROSITE; PS00687; ALDEHYDE_DEHYDR_GLU; 1.
PE 3: Inferred from homology;
KW Oxidoreductase {ECO:0000256|ARBA:ARBA00023002,
KW ECO:0000256|RuleBase:RU003345}.
FT DOMAIN 27..475
FT /note="Aldehyde dehydrogenase"
FT /evidence="ECO:0000259|Pfam:PF00171"
FT REGION 312..332
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 312..329
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT ACT_SITE 256
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU10007"
SQ SEQUENCE 487 AA; 52032 MW; 0D80F2F12288183D CRC64;
MSTHLTTVAG VAVDTRHFIG GERIASTETF TDVSPIDGSV LAEISRGTAM EAAAAVAAAK
AAFPAWAATP RAERARLLHA IADGVERRLE ELALVETTDN GALLRSHRRG VMPRVAHNFR
FFANWLLELD HEDFTTRGHT NHVTWDPAGP CVLITPWNAP LMLATWKVAP ALAAGDTVVL
KPAEWSPLTA SLLADIAAEA GLPAGVLNVV QGYGSEVGDP LTAHPDVRRI SFTGSVPTAR
HIAASAAANL TPLSLELGGK SPLLVFADAD LDLAAGLAVE QYDNAGQVCL AATRILVEAP
VAEEFTRRFT EKAAALRQGD PREESTDIGP TIHPRQLEKI DGFVRRALEA GARAVIGGHR
GEGQYYVPTL LTDVRQDSEI VQEEVFGPVL TLQTFEDEDE AVRLANDTRF GLAATVATGD
AERAARVTAR LVAGTVWVNC FFVRDLKAPF GGSRHSGVGR EGGTWSFDFY CDVKNTVTAP
KGFKDHG
//
