ID   A0A022ML09_9ACTN        Unreviewed;      1247 AA.
AC   A0A022ML09;
DT   11-JUN-2014, integrated into UniProtKB/TrEMBL.
DT   11-JUN-2014, sequence version 1.
DT   27-MAR-2024, entry version 34.
DE   SubName: Full=Alpha-mannosidase {ECO:0000313|EMBL:EYT83242.1};
GN   ORFNames=CF54_08480 {ECO:0000313|EMBL:EYT83242.1};
OS   Streptomyces sp. Tu 6176.
OC   Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
OC   Streptomycetaceae; Streptomyces.
OX   NCBI_TaxID=1470557 {ECO:0000313|EMBL:EYT83242.1, ECO:0000313|Proteomes:UP000020060};
RN   [1] {ECO:0000313|EMBL:EYT83242.1, ECO:0000313|Proteomes:UP000020060}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Tu 6176 {ECO:0000313|EMBL:EYT83242.1,
RC   ECO:0000313|Proteomes:UP000020060};
RA   Olano C., Cano-Prieto C., Mendez C., Salas J.A.;
RT   "Draft genome sequence of Streptomyces sp. Tu 6176, producer of the
RT   cytotoxic benzoxazol nataxazol.";
RL   Submitted (MAR-2014) to the EMBL/GenBank/DDBJ databases.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:EYT83242.1}.
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DR   EMBL; JFJQ01000253; EYT83242.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A022ML09; -.
DR   HOGENOM; CLU_003690_0_0_11; -.
DR   OrthoDB; 9804511at2; -.
DR   Proteomes; UP000020060; Unassembled WGS sequence.
DR   GO; GO:0030246; F:carbohydrate binding; IEA:InterPro.
DR   GO; GO:0005975; P:carbohydrate metabolic process; IEA:InterPro.
DR   Gene3D; 2.70.98.10; -; 1.
DR   Gene3D; 1.20.1050.60; alpha-1,2-mannosidase; 1.
DR   Gene3D; 1.20.1610.10; alpha-1,2-mannosidases domains; 1.
DR   Gene3D; 2.60.120.260; Galactose-binding domain-like; 2.
DR   Gene3D; 3.30.2080.10; GH92 mannosidase domain; 1.
DR   InterPro; IPR008928; 6-hairpin_glycosidase_sf.
DR   InterPro; IPR000421; FA58C.
DR   InterPro; IPR008979; Galactose-bd-like_sf.
DR   InterPro; IPR014718; GH-type_carb-bd.
DR   InterPro; IPR005887; GH92_a_mannosidase_put.
DR   InterPro; IPR041371; GH92_N.
DR   InterPro; IPR012939; Glyco_hydro_92.
DR   NCBIfam; TIGR01180; aman2_put; 1.
DR   PANTHER; PTHR12143; PEPTIDE N-GLYCANASE PNGASE -RELATED; 1.
DR   PANTHER; PTHR12143:SF43; PUTATIVE SUBFAMILY (AFU_ORTHOLOGUE AFUA_6G13760)-RELATED; 1.
DR   Pfam; PF00754; F5_F8_type_C; 1.
DR   Pfam; PF07971; Glyco_hydro_92; 1.
DR   Pfam; PF17678; Glyco_hydro_92N; 1.
DR   SUPFAM; SSF49785; Galactose-binding domain-like; 1.
DR   SUPFAM; SSF48208; Six-hairpin glycosidases; 1.
DR   PROSITE; PS50022; FA58C_3; 1.
PE   4: Predicted;
FT   DOMAIN          50..198
FT                   /note="F5/8 type C"
FT                   /evidence="ECO:0000259|PROSITE:PS50022"
FT   REGION          1..69
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          1114..1134
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   1247 AA;  134684 MW;  8C068CB71E864287 CRC64;
     MAAGSQGAAV ALPGKAPAAA REFTSSFESG DPAPDWLNTV DTGRDGGKRA SGVDGGYSTG
     IPGNVDDHVT GLRASAENSG SGEVKENLVD GEPGTKWLAF ESTGWVEFDL DKPIKITRYA
     LTSANDYGER DPKDWTLQGS ADGKDWKTVD SRSGESFAQR LQTKTYDLAA PAEYQHFRLD
     ISKNNGASGI LQLADVQFST GDDGGSTPPD MLSLVDRGPS GSPTAKAGAG YTGTRALRYA
     GRHTAKGRAY SYNKIFDVNV KVTRDTQLSY RLFPSMADGD RDYDATNVSV DLAFTDGTYL
     SRLGATDQHG FALSPQAQGA AKTLYVNQWN NVSSRIGSVA AGKTVDRVLL AYDSPAGPAK
     FRGWLDDVSI KQAAPERPKA HLADYALTTR GTNSSGSFSR GNNFPATAVP HGFNFWTPVT
     NAGSQSWLYE YARANNSDNL PTIQAFAASH EPSPWMGDRQ TFQVMPSAAS GTPDTGRTAR
     ALPFRHEKET AHPYYYGVTF ENGVKAEMAP TDHAAALRFT YPGDDASVLF DNVTDQAGLT
     LDKEHGVVTG FSDVKSGLST GATRLFVYGV FDKPVKDGSS SGVKGYLRFD AGKSRSVTLR
     LATSLISVDQ AKDNLRQEIP AGTSFGTVEQ RAQRTWDKLL GKVEVQGATP DQLTTLYSSM
     YRLYLYPNSG FEKVGGKDRY ASPFSAMTGE DTPTRTGAKI VDGKVYVNNG FWDTYRTTWP
     AYSLLTPSKA GEMVDGFVQG YKDGGWTSRW SSPGYADLMT GTSSDVAFAD AYVKGVPMDA
     KAAYDAAVKN ATVVPPSSGV GRKGMSTSPF LGYTSTATGE GLSWAMEGYV NDYGIAKMGE
     ALYKKTGQQH YKDEAQYFLN RAQDYVKMFD PKAGFFQGKD AKGNWRVDSA KYDPRVWGYD
     YTETNGWGYA FTAPQDSRGL ANLYGGQKGL ADKLDTYFAT PETATSEFAG SYGGIIHEMT
     EARDVRMGQY GHSNQVAHHV TYMYDAAGQP WKAQEKIREV LSRLYVGSEI GQGYHGDEDN
     GEQSAWYLFS SLGFYPLVMG SGEYAIGSPL FTKATVHLEN GHDLVVKAPR NSARNIYVQG
     VRFNGKRWDS TNLPHSLLSK GGVLEFDMGP RPSKWGTGKN AAPVSITTGD KAPAPRADVL
     KGEGALFDDT SATDATVTTV DLPVTGAAKA VQYTLTSSGD RTKAPRGWTL QASSDGTHWR
     TLDRRSGESF AWDKQTRPFT IASPGTYQKY RLVLDGSATL AEVELLA
//