ID   A0A022MN80_9ACTN        Unreviewed;       799 AA.
AC   A0A022MN80;
DT   11-JUN-2014, integrated into UniProtKB/TrEMBL.
DT   11-JUN-2014, sequence version 1.
DT   27-MAR-2024, entry version 43.
DE   RecName: Full=DNA 3'-5' helicase {ECO:0000256|ARBA:ARBA00034808};
DE            EC=5.6.2.4 {ECO:0000256|ARBA:ARBA00034808};
GN   ORFNames=CF54_04590 {ECO:0000313|EMBL:EYT83897.1};
OS   Streptomyces sp. Tu 6176.
OC   Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
OC   Streptomycetaceae; Streptomyces.
OX   NCBI_TaxID=1470557 {ECO:0000313|EMBL:EYT83897.1, ECO:0000313|Proteomes:UP000020060};
RN   [1] {ECO:0000313|EMBL:EYT83897.1, ECO:0000313|Proteomes:UP000020060}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Tu 6176 {ECO:0000313|EMBL:EYT83897.1,
RC   ECO:0000313|Proteomes:UP000020060};
RA   Olano C., Cano-Prieto C., Mendez C., Salas J.A.;
RT   "Draft genome sequence of Streptomyces sp. Tu 6176, producer of the
RT   cytotoxic benzoxazol nataxazol.";
RL   Submitted (MAR-2014) to the EMBL/GenBank/DDBJ databases.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=ATP + H2O = ADP + H(+) + phosphate; Xref=Rhea:RHEA:13065,
CC         ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616,
CC         ChEBI:CHEBI:43474, ChEBI:CHEBI:456216; EC=5.6.2.4;
CC         Evidence={ECO:0000256|ARBA:ARBA00034618};
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:EYT83897.1}.
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DR   EMBL; JFJQ01000124; EYT83897.1; -; Genomic_DNA.
DR   RefSeq; WP_051576108.1; NZ_KK106988.1.
DR   AlphaFoldDB; A0A022MN80; -.
DR   HOGENOM; CLU_023846_0_0_11; -.
DR   OrthoDB; 3196525at2; -.
DR   Proteomes; UP000020060; Unassembled WGS sequence.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0016887; F:ATP hydrolysis activity; IEA:RHEA.
DR   GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR   GO; GO:0003678; F:DNA helicase activity; IEA:InterPro.
DR   Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 2.
DR   InterPro; IPR014017; DNA_helicase_UvrD-like_C.
DR   InterPro; IPR000212; DNA_helicase_UvrD/REP.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR014016; UvrD-like_ATP-bd.
DR   PANTHER; PTHR11070:SF2; ATP-DEPENDENT DNA HELICASE SRS2; 1.
DR   PANTHER; PTHR11070; UVRD / RECB / PCRA DNA HELICASE FAMILY MEMBER; 1.
DR   Pfam; PF13245; AAA_19; 1.
DR   Pfam; PF13361; UvrD_C; 1.
DR   SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR   PROSITE; PS51198; UVRD_HELICASE_ATP_BIND; 1.
PE   4: Predicted;
KW   ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|PROSITE-
KW   ProRule:PRU00560};
KW   Helicase {ECO:0000256|ARBA:ARBA00022806, ECO:0000256|PROSITE-
KW   ProRule:PRU00560};
KW   Hydrolase {ECO:0000256|ARBA:ARBA00022801, ECO:0000256|PROSITE-
KW   ProRule:PRU00560};
KW   Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741, ECO:0000256|PROSITE-
KW   ProRule:PRU00560}.
FT   DOMAIN          280..585
FT                   /note="UvrD-like helicase ATP-binding"
FT                   /evidence="ECO:0000259|PROSITE:PS51198"
FT   REGION          127..155
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   BINDING         301..308
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00560"
SQ   SEQUENCE   799 AA;  87943 MW;  25D4F4F4EFE2CB5E CRC64;
     MSHGVRTQVA VTPQANEDIR RLDAATKNAV GDFVRRLRAD RSNRALRLTL LREAGGNGRL
     FLAALDGSRM GLLLETEENR FSLLAVRVGP SAREELARLT VEINAVSGGV ELVDQSEVSA
     NVVAMPVRPE PAPEPGIAPE RPSVTETSTA PSGVGAGAST VAPAALPVPL FAPYEDEELI
     GLGVIASLLP ALRRITDSHQ LSTVLSHNLP GLTREVLLAL HDGMEPSEVR RFITAPWRAD
     EEIDPQDWAR AARRPVSQVS TDDAAVLDAL GDGFDAWRLF LHPEQQRLAT ASFKGSAKVT
     GGPGTGKTVV ALHRVRHLVA QLPPGQTRPV LLTTYNTNLA ADLKERLHRL GGDALVRRVD
     VKSVDQLARE VVEQHPSSVL GTPMGDEEAM ALWHRVCAEA GVFDFDADFL DSEFKHVILA
     QGCGTERLYL RAERRGRGVL QRAGRKQVWE LVAKYRTILE GPPRRTTYAL IADEAARIEE
     HRMAKAAEQA RYKEEYGGLD LIHREAGSGM WLKPRYHHIV VDEAQDLSAS HWRMLRAMVA
     PGPNDLFLVG DAHQRIYSHQ VVLGRLGIST PGRASRRLTL NYRTTREILG SAHGLVHGET
     FDDLDDGADT LDGYRSVLTG LAPQYWRAPD WETEMRAVAT LLKERHERYG TPYSAMAVSV
     PDKAAVTQLA YTLACEPFLI PASEIGREGP RDTDTVRIGT MHRFKGLEFQ RVFLAGISDG
     LVPHQRIETF RLSNPDRYRQ EEQRARSLLF VAATRARDEL VVSWHGRSSR YLPRHADHDA
     GRATSLLTGD GPPSDSNAA
//