ID A0A022MNA8_9ACTN Unreviewed; 274 AA.
AC A0A022MNA8;
DT 11-JUN-2014, integrated into UniProtKB/TrEMBL.
DT 11-JUN-2014, sequence version 1.
DT 24-JAN-2024, entry version 24.
DE RecName: Full=isochorismate synthase {ECO:0000256|ARBA:ARBA00012824};
DE EC=5.4.4.2 {ECO:0000256|ARBA:ARBA00012824};
DE AltName: Full=Isochorismate mutase {ECO:0000256|ARBA:ARBA00041564};
DE Flags: Fragment;
GN ORFNames=CF54_07485 {ECO:0000313|EMBL:EYT83419.1};
OS Streptomyces sp. Tu 6176.
OC Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
OC Streptomycetaceae; Streptomyces.
OX NCBI_TaxID=1470557 {ECO:0000313|EMBL:EYT83419.1, ECO:0000313|Proteomes:UP000020060};
RN [1] {ECO:0000313|EMBL:EYT83419.1, ECO:0000313|Proteomes:UP000020060}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Tu 6176 {ECO:0000313|EMBL:EYT83419.1,
RC ECO:0000313|Proteomes:UP000020060};
RA Olano C., Cano-Prieto C., Mendez C., Salas J.A.;
RT "Draft genome sequence of Streptomyces sp. Tu 6176, producer of the
RT cytotoxic benzoxazol nataxazol.";
RL Submitted (MAR-2014) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=chorismate = isochorismate; Xref=Rhea:RHEA:18985,
CC ChEBI:CHEBI:29748, ChEBI:CHEBI:29780; EC=5.4.4.2;
CC Evidence={ECO:0000256|ARBA:ARBA00000799};
CC -!- SIMILARITY: Belongs to the isochorismate synthase family.
CC {ECO:0000256|ARBA:ARBA00005297}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:EYT83419.1}.
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DR EMBL; JFJQ01000225; EYT83419.1; -; Genomic_DNA.
DR RefSeq; WP_037889074.1; NZ_KK106988.1.
DR AlphaFoldDB; A0A022MNA8; -.
DR HOGENOM; CLU_1013809_0_0_11; -.
DR OrthoDB; 9806579at2; -.
DR Proteomes; UP000020060; Unassembled WGS sequence.
DR GO; GO:0008909; F:isochorismate synthase activity; IEA:UniProtKB-EC.
DR GO; GO:0009058; P:biosynthetic process; IEA:InterPro.
DR Gene3D; 3.60.120.10; Anthranilate synthase; 1.
DR InterPro; IPR005801; ADC_synthase.
DR InterPro; IPR015890; Chorismate_C.
DR InterPro; IPR004561; IsoChor_synthase.
DR NCBIfam; TIGR00543; isochor_syn; 1.
DR PANTHER; PTHR42839; ISOCHORISMATE SYNTHASE ENTC; 1.
DR PANTHER; PTHR42839:SF2; ISOCHORISMATE SYNTHASE ENTC; 1.
DR Pfam; PF00425; Chorismate_bind; 1.
DR SUPFAM; SSF56322; ADC synthase; 1.
PE 3: Inferred from homology;
KW Isomerase {ECO:0000256|ARBA:ARBA00023235, ECO:0000313|EMBL:EYT83419.1}.
FT DOMAIN 8..262
FT /note="Chorismate-utilising enzyme C-terminal"
FT /evidence="ECO:0000259|Pfam:PF00425"
FT NON_TER 1
FT /evidence="ECO:0000313|EMBL:EYT83419.1"
SQ SEQUENCE 274 AA; 28635 MW; 9673BCB68686B747 CRC64;
LRPVPAPERY AEAVAAAVRR MRDGEFGKVV LARALDLTAD RTPGLPAMLQ RLARRDPHGY
TFAVPTATGG TLLGASPELL VSRRGTALVA NPLAGSAPRS EDLAEDVQRA AALLRSAKDL
HEHAVVVDAM RAALAPYCAT LHVPRRPTLV KTAAMWHLST TLTGTLADPA ATALDLACAV
HPTPAVCGAP TAHARRVIGE LEPFDRGLYT GIVGWGDAAG DGEWVVTIRC AETRGQDLRL
YAGAGVVADS DPAAETAETG AKFRTFLDAV GAAL
//
