ID A0A022PU36_ERYGU Unreviewed; 868 AA.
AC A0A022PU36;
DT 11-JUN-2014, integrated into UniProtKB/TrEMBL.
DT 11-JUN-2014, sequence version 1.
DT 27-MAR-2024, entry version 35.
DE RecName: Full=NB-ARC domain-containing protein {ECO:0000259|Pfam:PF00931};
GN ORFNames=MIMGU_mgv1a022681mg {ECO:0000313|EMBL:EYU19311.1};
OS Erythranthe guttata (Yellow monkey flower) (Mimulus guttatus).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC asterids; lamiids; Lamiales; Phrymaceae; Erythranthe.
OX NCBI_TaxID=4155 {ECO:0000313|EMBL:EYU19311.1, ECO:0000313|Proteomes:UP000030748};
RN [1] {ECO:0000313|EMBL:EYU19311.1, ECO:0000313|Proteomes:UP000030748}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. DUN x IM62 {ECO:0000313|Proteomes:UP000030748};
RX PubMed=24225854; DOI=10.1073/pnas.1319032110;
RA Hellsten U., Wright K.M., Jenkins J., Shu S., Yuan Y., Wessler S.R.,
RA Schmutz J., Willis J.H., Rokhsar D.S.;
RT "Fine-scale variation in meiotic recombination in Mimulus inferred from
RT population shotgun sequencing.";
RL Proc. Natl. Acad. Sci. U.S.A. 110:19478-19482(2013).
CC -!- FUNCTION: Confers resistance to late blight (Phytophthora infestans)
CC races carrying the avirulence gene Avr1. Resistance proteins guard the
CC plant against pathogens that contain an appropriate avirulence protein
CC via an indirect interaction with this avirulence protein. That triggers
CC a defense system including the hypersensitive response, which restricts
CC the pathogen growth. {ECO:0000256|ARBA:ARBA00002074}.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004170};
CC Peripheral membrane protein {ECO:0000256|ARBA:ARBA00004170}.
CC -!- SIMILARITY: Belongs to the disease resistance NB-LRR family.
CC {ECO:0000256|ARBA:ARBA00008894}.
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DR EMBL; KI632299; EYU19311.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A022PU36; -.
DR eggNOG; KOG4658; Eukaryota.
DR Proteomes; UP000030748; Unassembled WGS sequence.
DR GO; GO:0043531; F:ADP binding; IEA:InterPro.
DR GO; GO:0006952; P:defense response; IEA:UniProtKB-KW.
DR GO; GO:0051707; P:response to other organism; IEA:UniProt.
DR Gene3D; 1.20.5.4130; -; 1.
DR Gene3D; 1.10.8.430; Helical domain of apoptotic protease-activating factors; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR Gene3D; 3.80.10.10; Ribonuclease Inhibitor; 1.
DR Gene3D; 1.10.10.10; Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain; 1.
DR InterPro; IPR042197; Apaf_helical.
DR InterPro; IPR044974; Disease_R_plants.
DR InterPro; IPR032675; LRR_dom_sf.
DR InterPro; IPR002182; NB-ARC.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR036388; WH-like_DNA-bd_sf.
DR PANTHER; PTHR23155; DISEASE RESISTANCE PROTEIN RP; 1.
DR PANTHER; PTHR23155:SF1235; DISEASE RESISTANCE RPP13-LIKE PROTEIN 1; 1.
DR Pfam; PF00931; NB-ARC; 2.
DR PRINTS; PR00364; DISEASERSIST.
DR SUPFAM; SSF52058; L domain-like; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
PE 3: Inferred from homology;
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Hypersensitive response {ECO:0000256|ARBA:ARBA00022667};
KW Membrane {ECO:0000256|ARBA:ARBA00023136};
KW Plant defense {ECO:0000256|ARBA:ARBA00022821};
KW Reference proteome {ECO:0000313|Proteomes:UP000030748}.
FT DOMAIN 175..291
FT /note="NB-ARC"
FT /evidence="ECO:0000259|Pfam:PF00931"
FT DOMAIN 303..364
FT /note="NB-ARC"
FT /evidence="ECO:0000259|Pfam:PF00931"
SQ SEQUENCE 868 AA; 100274 MW; 2DE2F466ACFC60F7 CRC64;
MAYAAVVSLK HTIEQLLSND ETKDVLSLSE TMLIYNELPH LISFLKTIKS LPNNKIVDPA
SEKRVKDAAQ KLEDLIDSLV SDLFLSESKR SISADEISLN FSFSQQLQNV NEEVGSFLSA
TLPKNINDKE QQQQQQQQQQ QQQQQQQQQQ ICRYSSSSEY NTWNQQKNLV VGLDDQIKQL
KEWIFDPTPF MSATTLAGMT GIGKTTLAKQ VYIDPLVIEK FEIRLFVHIG PQYSQSEEIV
LLVLDQLGVV VPSDKLVDHK NKDYLTQQLR KALSSKKYLI VLDDVWTNEK IQRYLKRPNV
FLLPLLNESK SWKLLHQTAF GNSEEKCSRE LELIGKKIAR NCDGLPAPII QVGENLRGKS
FQERKALSEN EDPLVITRDD DTPLSKALYF SYMMLPQYLK LCFLYMGVFP KYYEIFQSKL
IKLWVCEGLL DPEQILGILD AEGTAGKYLD LLICQSVVLR EKQTSLDDEI SKNCRLHFTF
RSLCVTESKS EFCFHILKKF TDCTPENIKG HKRLCVHNNI VLAFPQVHEW MESVPNARSL
LCFGPKQKYP IVFPFNFRLL KIIDALAIRF YEFPLQILVL VHLSYLAITC DGKLPNSISR
LWNLEILIVC RHHNIKLSNN CPIYLPIEIW KMKKLKQLSC MGFDMPAPPP DDSHLILEML
LTVSGVSVHS CTMEVLSRIP NLKRIAVQIE SAHDSNENFS FFNHFASLYE AFESFKCVVV
NPNLKSQIVR CIPNFPQDIR KLCLSGCGLP WENMGVIASL PNLTVLTLRW YAFWGPVWKT
NEVQFPSLQY LLLEDLDIER WEFDGELFPY LDHVIFRHCY KLKKIQNQLE FVNRVEVDDC
SLSFEKKMRK WRSTYDIEAK IRSSSTDL
//
