ID A0A022PWL7_ERYGU Unreviewed; 568 AA.
AC A0A022PWL7;
DT 11-JUN-2014, integrated into UniProtKB/TrEMBL.
DT 11-JUN-2014, sequence version 1.
DT 27-MAR-2024, entry version 32.
DE RecName: Full=Beta-hexosaminidase {ECO:0000256|PIRNR:PIRNR001093};
DE EC=3.2.1.52 {ECO:0000256|PIRNR:PIRNR001093};
GN ORFNames=MIMGU_mgv1a003720mg {ECO:0000313|EMBL:EYU19904.1};
OS Erythranthe guttata (Yellow monkey flower) (Mimulus guttatus).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC asterids; lamiids; Lamiales; Phrymaceae; Erythranthe.
OX NCBI_TaxID=4155 {ECO:0000313|EMBL:EYU19904.1, ECO:0000313|Proteomes:UP000030748};
RN [1] {ECO:0000313|EMBL:EYU19904.1, ECO:0000313|Proteomes:UP000030748}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. DUN x IM62 {ECO:0000313|Proteomes:UP000030748};
RX PubMed=24225854; DOI=10.1073/pnas.1319032110;
RA Hellsten U., Wright K.M., Jenkins J., Shu S., Yuan Y., Wessler S.R.,
RA Schmutz J., Willis J.H., Rokhsar D.S.;
RT "Fine-scale variation in meiotic recombination in Mimulus inferred from
RT population shotgun sequencing.";
RL Proc. Natl. Acad. Sci. U.S.A. 110:19478-19482(2013).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=Hydrolysis of terminal non-reducing N-acetyl-D-hexosamine
CC residues in N-acetyl-beta-D-hexosaminides.; EC=3.2.1.52;
CC Evidence={ECO:0000256|ARBA:ARBA00001231,
CC ECO:0000256|PIRNR:PIRNR001093};
CC -!- SIMILARITY: Belongs to the glycosyl hydrolase 20 family.
CC {ECO:0000256|ARBA:ARBA00006285, ECO:0000256|PIRNR:PIRNR001093}.
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DR EMBL; KI632289; EYU19904.1; -; Genomic_DNA.
DR RefSeq; XP_012858596.1; XM_013003142.1.
DR AlphaFoldDB; A0A022PWL7; -.
DR STRING; 4155.A0A022PWL7; -.
DR GeneID; 105977772; -.
DR KEGG; egt:105977772; -.
DR eggNOG; KOG2499; Eukaryota.
DR OMA; NYCVEPP; -.
DR OrthoDB; 178991at2759; -.
DR PhylomeDB; A0A022PWL7; -.
DR Proteomes; UP000030748; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IBA:GO_Central.
DR GO; GO:0004563; F:beta-N-acetylhexosaminidase activity; IBA:GO_Central.
DR GO; GO:0102148; F:N-acetyl-beta-D-galactosaminidase activity; IEA:UniProtKB-EC.
DR GO; GO:0005975; P:carbohydrate metabolic process; IEA:InterPro.
DR GO; GO:0030203; P:glycosaminoglycan metabolic process; IBA:GO_Central.
DR CDD; cd06562; GH20_HexA_HexB-like; 1.
DR Gene3D; 3.30.379.10; Chitobiase/beta-hexosaminidase domain 2-like; 1.
DR Gene3D; 3.20.20.80; Glycosidases; 1.
DR InterPro; IPR025705; Beta_hexosaminidase_sua/sub.
DR InterPro; IPR015883; Glyco_hydro_20_cat.
DR InterPro; IPR017853; Glycoside_hydrolase_SF.
DR InterPro; IPR029018; Hex-like_dom2.
DR InterPro; IPR029019; HEX_eukaryotic_N.
DR PANTHER; PTHR22600; BETA-HEXOSAMINIDASE; 1.
DR PANTHER; PTHR22600:SF40; BETA-HEXOSAMINIDASE 1; 1.
DR Pfam; PF00728; Glyco_hydro_20; 1.
DR Pfam; PF14845; Glycohydro_20b2; 1.
DR PIRSF; PIRSF001093; B-hxosamndse_ab_euk; 1.
DR PRINTS; PR00738; GLHYDRLASE20.
DR SUPFAM; SSF51445; (Trans)glycosidases; 1.
DR SUPFAM; SSF55545; beta-N-acetylhexosaminidase-like domain; 1.
PE 3: Inferred from homology;
KW Glycosidase {ECO:0000256|ARBA:ARBA00023295, ECO:0000256|PIRNR:PIRNR001093};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801, ECO:0000256|PIRNR:PIRNR001093};
KW Reference proteome {ECO:0000313|Proteomes:UP000030748}.
FT DOMAIN 69..189
FT /note="Beta-hexosaminidase eukaryotic type N-terminal"
FT /evidence="ECO:0000259|Pfam:PF14845"
FT DOMAIN 214..518
FT /note="Glycoside hydrolase family 20 catalytic"
FT /evidence="ECO:0000259|Pfam:PF00728"
FT ACT_SITE 361
FT /note="Proton donor"
FT /evidence="ECO:0000256|PIRSR:PIRSR001093-1"
SQ SEQUENCE 568 AA; 63990 MW; C93E1F33F3B1271F CRC64;
MNSAITNSLS NLCKKMNIPF MSNPQSYLLL VLLIFSQSQI IRCRNLVLNQ QQQQFNNGAG
DGDDSLTYIW PLPRQHTSGN QTLTVNPNLS LVTSGNGSNS LIVSEAFDRY KKIIFKHTSS
KLPGTGIDYD LNKLSVVVHS DNEELQLGVD ESYTLMVAAT DKLSIIGEIT IEADSVYGAL
RGLETLSQLC AFDYGTKSVK LYNAPWYIQD KPRFKYRGLM LDTSRHYLPM EIIKQVIESM
SYAKLNVLHW HIIDEESFPL EVPTYPNLWK GAYTKWERYT VDDASEIVNF AKMRGINVMA
EVDVPGHAES WGTGYPDLWP SASCKEPLDV SKNFTFDLIS GILSDMRKIF PFELFHLGGD
EVHTDCWTST PHVNQWLQDQ NMTGKDAYKY FVLRAQEIAV ALNWTPVNWE ETFNSFPESL
NNETVVHNWL GSGVCPKAVA KGFRCIFSNQ GVWYLDHLDV PWDSVYYADP LEGITDSSEQ
KLVLGGEVCM WGETADASNV QQTIWPRAAA AAERLWSEAD SASSRNTSVL PRLEYFRCLL
TRRGVQAAPV QNFYARSPPT GTGSCYSQ
//
