ID A0A022PZT6_ERYGU Unreviewed; 857 AA.
AC A0A022PZT6;
DT 11-JUN-2014, integrated into UniProtKB/TrEMBL.
DT 11-JUN-2014, sequence version 1.
DT 27-MAR-2024, entry version 29.
DE RecName: Full=NB-ARC domain-containing protein {ECO:0000259|Pfam:PF00931};
DE Flags: Fragment;
GN ORFNames=MIMGU_mgv1a017843mg {ECO:0000313|EMBL:EYU21847.1};
OS Erythranthe guttata (Yellow monkey flower) (Mimulus guttatus).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC asterids; lamiids; Lamiales; Phrymaceae; Erythranthe.
OX NCBI_TaxID=4155 {ECO:0000313|EMBL:EYU21847.1, ECO:0000313|Proteomes:UP000030748};
RN [1] {ECO:0000313|EMBL:EYU21847.1, ECO:0000313|Proteomes:UP000030748}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. DUN x IM62 {ECO:0000313|Proteomes:UP000030748};
RX PubMed=24225854; DOI=10.1073/pnas.1319032110;
RA Hellsten U., Wright K.M., Jenkins J., Shu S., Yuan Y., Wessler S.R.,
RA Schmutz J., Willis J.H., Rokhsar D.S.;
RT "Fine-scale variation in meiotic recombination in Mimulus inferred from
RT population shotgun sequencing.";
RL Proc. Natl. Acad. Sci. U.S.A. 110:19478-19482(2013).
CC -!- FUNCTION: Confers resistance to late blight (Phytophthora infestans)
CC races carrying the avirulence gene Avr1. Resistance proteins guard the
CC plant against pathogens that contain an appropriate avirulence protein
CC via an indirect interaction with this avirulence protein. That triggers
CC a defense system including the hypersensitive response, which restricts
CC the pathogen growth. {ECO:0000256|ARBA:ARBA00002074}.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004170};
CC Peripheral membrane protein {ECO:0000256|ARBA:ARBA00004170}.
CC -!- SIMILARITY: Belongs to the disease resistance NB-LRR family.
CC {ECO:0000256|ARBA:ARBA00008894}.
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DR EMBL; KI632223; EYU21847.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A022PZT6; -.
DR eggNOG; KOG4658; Eukaryota.
DR Proteomes; UP000030748; Unassembled WGS sequence.
DR GO; GO:0043531; F:ADP binding; IEA:InterPro.
DR GO; GO:0006952; P:defense response; IEA:UniProtKB-KW.
DR GO; GO:0051707; P:response to other organism; IEA:UniProt.
DR Gene3D; 1.20.5.4130; -; 1.
DR Gene3D; 1.10.8.430; Helical domain of apoptotic protease-activating factors; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR Gene3D; 3.80.10.10; Ribonuclease Inhibitor; 1.
DR Gene3D; 1.10.10.10; Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain; 1.
DR InterPro; IPR042197; Apaf_helical.
DR InterPro; IPR044974; Disease_R_plants.
DR InterPro; IPR032675; LRR_dom_sf.
DR InterPro; IPR002182; NB-ARC.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR036388; WH-like_DNA-bd_sf.
DR PANTHER; PTHR23155; DISEASE RESISTANCE PROTEIN RP; 1.
DR PANTHER; PTHR23155:SF1235; DISEASE RESISTANCE RPP13-LIKE PROTEIN 1; 1.
DR Pfam; PF00931; NB-ARC; 1.
DR PRINTS; PR00364; DISEASERSIST.
DR SUPFAM; SSF52058; L domain-like; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
PE 3: Inferred from homology;
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Hypersensitive response {ECO:0000256|ARBA:ARBA00022667};
KW Membrane {ECO:0000256|ARBA:ARBA00023136};
KW Plant defense {ECO:0000256|ARBA:ARBA00022821};
KW Reference proteome {ECO:0000313|Proteomes:UP000030748}.
FT DOMAIN 162..397
FT /note="NB-ARC"
FT /evidence="ECO:0000259|Pfam:PF00931"
FT NON_TER 1
FT /evidence="ECO:0000313|EMBL:EYU21847.1"
SQ SEQUENCE 857 AA; 98273 MW; 0A481F324A802F44 CRC64;
YAALLSLKYI IQQIQLHPRP PISFDQNQVD SLTKSLNFLQ DFLEGYSYGS SSISREAVDV
LESRIKNAAL AGEDLIETRV VDQIHGGSTA HGKKISSSDF HQDLEMVIQD MGFIKKDVME
IKENHIGIED HLLRKSSTLG GAGASSSPST RQNAMVGFDH LLNVVMDKLT GGQSNLRIIS
IVGMGGIGKT TLAKNAYLKF MKHFDIQAWV TISQNYSVRQ ILIEILLCIS KEESPESLSA
KSEGELGERV HKTLWKRRYL IVMDDIWSID VWDKVQIFFP DNGQGSRVMI TTRLSNVASI
GSYGIVMGFL NEDKSWDLLC RSVFKEEKDC PPELVEIGKK IAKNCEGLPL SIVVIGGHLA
KSERTKEHWE YISENTNTIV NSEDNERCLK ALQLSYNHLP VHLKPCFLYM GVFPEGNMIR
VSWLVKLWVS EGFVKPINCK SLEVVSREYL QELCDRNLIL VHKRGSNGNI KYCKIHDLLR
DLCLREAERE KFLYVRRPMS EKDPILHTLQ DVPLVRSLIC NFEERLPLLD FRLLRVLKAD
DKNSYFDNNR PYKYSVEVVF RLVNLRFIAI RSDVPKNSGF PSLVNLLWNL QTLIVNGIFG
VVAPCEIWNM TQLKHVHFFQ LKLPDPPIGG KGNEFVLENL QTLTHIRNFK CGEEVVKRIP
NINKLQISYF EEPQGFLSYS LDNLGQLHKL ESLRLSIYSE NKHLLQNFIL PNSLKKLTLM
GTCLKWEDMK TKICLLPNLQ VLKLKEYSFV GTEWETVEGQ FCNLRYLLIR SCRDLEWWTT
DSSHFPRLEH LHLRYLHKLK EIPSCIGEIS TLQSIELISC SKLAVISAKQ ILKEQEDFGN
EDFRVQVFDT MSLGETW
//
