ID   A0A022QC49_ERYGU        Unreviewed;       665 AA.
AC   A0A022QC49;
DT   11-JUN-2014, integrated into UniProtKB/TrEMBL.
DT   11-JUN-2014, sequence version 1.
DT   27-MAR-2024, entry version 32.
DE   RecName: Full=DUF726 domain-containing protein {ECO:0008006|Google:ProtNLM};
GN   ORFNames=MIMGU_mgv1a002505mg {ECO:0000313|EMBL:EYU24080.1};
OS   Erythranthe guttata (Yellow monkey flower) (Mimulus guttatus).
OC   Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC   Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC   asterids; lamiids; Lamiales; Phrymaceae; Erythranthe.
OX   NCBI_TaxID=4155 {ECO:0000313|EMBL:EYU24080.1, ECO:0000313|Proteomes:UP000030748};
RN   [1] {ECO:0000313|EMBL:EYU24080.1, ECO:0000313|Proteomes:UP000030748}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=cv. DUN x IM62 {ECO:0000313|Proteomes:UP000030748};
RX   PubMed=24225854; DOI=10.1073/pnas.1319032110;
RA   Hellsten U., Wright K.M., Jenkins J., Shu S., Yuan Y., Wessler S.R.,
RA   Schmutz J., Willis J.H., Rokhsar D.S.;
RT   "Fine-scale variation in meiotic recombination in Mimulus inferred from
RT   population shotgun sequencing.";
RL   Proc. Natl. Acad. Sci. U.S.A. 110:19478-19482(2013).
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC       pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC   -!- SIMILARITY: Belongs to the TMCO4 family.
CC       {ECO:0000256|ARBA:ARBA00009824}.
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DR   EMBL; KI632147; EYU24080.1; -; Genomic_DNA.
DR   RefSeq; XP_012853543.1; XM_012998089.1.
DR   AlphaFoldDB; A0A022QC49; -.
DR   GeneID; 105973082; -.
DR   KEGG; egt:105973082; -.
DR   eggNOG; KOG2385; Eukaryota.
DR   OMA; ERYALEW; -.
DR   OrthoDB; 8526at2759; -.
DR   PhylomeDB; A0A022QC49; -.
DR   Proteomes; UP000030748; Unassembled WGS sequence.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR   Gene3D; 3.40.50.1820; alpha/beta hydrolase; 1.
DR   InterPro; IPR029058; AB_hydrolase.
DR   InterPro; IPR007941; DUF726.
DR   PANTHER; PTHR17920:SF3; TRANSMEMBRANE AND COILED-COIL DOMAIN-CONTAINING PROTEIN 4; 1.
DR   PANTHER; PTHR17920; TRANSMEMBRANE AND COILED-COIL DOMAIN-CONTAINING PROTEIN 4 TMCO4; 1.
DR   Pfam; PF05277; DUF726; 1.
DR   SUPFAM; SSF53474; alpha/beta-Hydrolases; 1.
PE   3: Inferred from homology;
KW   Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000030748};
KW   Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW   ECO:0000256|SAM:Phobius}.
FT   TRANSMEM        309..336
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        356..382
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        474..495
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   REGION          36..64
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          138..182
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        50..64
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        141..179
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   665 AA;  71790 MW;  88D758AF02E66C5F CRC64;
     MSSSSTSMLT PTQKYGAGAL FAMALHQTQI HQTIQLGLPD GGGGAAEERL SSGSGSNSDS
     EDPQLWVHES SGLLRPIFKF LEIDGSAWLG LEETAACSPA NNHFGAFLRL LVDENRDVSS
     ETAEKEVALV KGIDAMSASM EKSPAEHDSK KEKQREYETA CKEKFSTPES IEESKVKDSS
     QQETNVIATS AVEQAHKHSI FENDGKPMEE ANVVSYTRKV TVLYEVLSAC LANIPEEDNK
     DATKRTNGYD ARHRVALRLL ATWFDIKWIK MEAIETVVAC SAMAILTEEL NEEDKSPEST
     WAKWKRGGII GAAAITGGTL MAITGGLAAP AIAAGFGALA PTLGTIIPVI GASGFAAVAS
     AAGSVVGSVA VAASFGAAGA GLTGTKVARR IGDVEEFEFK TIGENHNQGR LAVEISISGF
     VFEEQDFIRP WEGQHDNLER YAIQWESKNL IAVSTAIQDW LTSKIATEMM KQGAMMTVLS
     TLMTALAWPS ALLTLTNFID SKWTIVIDRS DKAGKLLAEV LLKGLQGQRP VTLVGFSLGA
     RVIFRCLQIL AESDANAGLV ERVVLLGAPI AIKDMNWEAT RKVVAGRYIN AYSTDDWMLG
     IAFRANLLTK GLAGIQPVDV PGIENVDVTE IIEGHSSYLW GTQHILEQLE LDTYYPVFNR
     KIVKS
//