ID   A0A022QD14_ERYGU        Unreviewed;       775 AA.
AC   A0A022QD14;
DT   11-JUN-2014, integrated into UniProtKB/TrEMBL.
DT   11-JUN-2014, sequence version 1.
DT   27-MAR-2024, entry version 38.
DE   RecName: Full=Terpene cyclase/mutase family member {ECO:0000256|RuleBase:RU362003};
DE            EC=5.4.99.- {ECO:0000256|RuleBase:RU362003};
GN   ORFNames=MIMGU_mgv1a001674mg {ECO:0000313|EMBL:EYU26562.1};
OS   Erythranthe guttata (Yellow monkey flower) (Mimulus guttatus).
OC   Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC   Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC   asterids; lamiids; Lamiales; Phrymaceae; Erythranthe.
OX   NCBI_TaxID=4155 {ECO:0000313|EMBL:EYU26562.1, ECO:0000313|Proteomes:UP000030748};
RN   [1] {ECO:0000313|EMBL:EYU26562.1, ECO:0000313|Proteomes:UP000030748}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=cv. DUN x IM62 {ECO:0000313|Proteomes:UP000030748};
RX   PubMed=24225854; DOI=10.1073/pnas.1319032110;
RA   Hellsten U., Wright K.M., Jenkins J., Shu S., Yuan Y., Wessler S.R.,
RA   Schmutz J., Willis J.H., Rokhsar D.S.;
RT   "Fine-scale variation in meiotic recombination in Mimulus inferred from
RT   population shotgun sequencing.";
RL   Proc. Natl. Acad. Sci. U.S.A. 110:19478-19482(2013).
CC   -!- SIMILARITY: Belongs to the terpene cyclase/mutase family.
CC       {ECO:0000256|ARBA:ARBA00009755, ECO:0000256|RuleBase:RU362003}.
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DR   EMBL; KI631651; EYU26562.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A022QD14; -.
DR   STRING; 4155.A0A022QD14; -.
DR   eggNOG; KOG0497; Eukaryota.
DR   Proteomes; UP000030748; Unassembled WGS sequence.
DR   GO; GO:0005811; C:lipid droplet; IEA:InterPro.
DR   GO; GO:0016866; F:intramolecular transferase activity; IEA:InterPro.
DR   GO; GO:0016104; P:triterpenoid biosynthetic process; IEA:InterPro.
DR   CDD; cd02892; SQCY_1; 1.
DR   Gene3D; 1.50.10.20; -; 2.
DR   InterPro; IPR001330; PFTB_repeat.
DR   InterPro; IPR032696; SQ_cyclase_C.
DR   InterPro; IPR032697; SQ_cyclase_N.
DR   InterPro; IPR018333; Squalene_cyclase.
DR   InterPro; IPR002365; Terpene_synthase_CS.
DR   InterPro; IPR008930; Terpenoid_cyclase/PrenylTrfase.
DR   NCBIfam; TIGR01787; squalene_cyclas; 1.
DR   PANTHER; PTHR11764; TERPENE CYCLASE/MUTASE FAMILY MEMBER; 1.
DR   PANTHER; PTHR11764:SF89; TERPENE CYCLASE_MUTASE FAMILY MEMBER; 1.
DR   Pfam; PF00432; Prenyltrans; 1.
DR   Pfam; PF13243; SQHop_cyclase_C; 1.
DR   Pfam; PF13249; SQHop_cyclase_N; 1.
DR   SFLD; SFLDG01016; Prenyltransferase_Like_2; 1.
DR   SUPFAM; SSF48239; Terpenoid cyclases/Protein prenyltransferases; 2.
DR   PROSITE; PS01074; TERPENE_SYNTHASES; 1.
PE   3: Inferred from homology;
KW   Isomerase {ECO:0000256|RuleBase:RU362003};
KW   Reference proteome {ECO:0000313|Proteomes:UP000030748};
KW   Repeat {ECO:0000256|ARBA:ARBA00022737}.
FT   DOMAIN          155..420
FT                   /note="Squalene cyclase N-terminal"
FT                   /evidence="ECO:0000259|Pfam:PF13249"
FT   DOMAIN          432..769
FT                   /note="Squalene cyclase C-terminal"
FT                   /evidence="ECO:0000259|Pfam:PF13243"
SQ   SEQUENCE   775 AA;  88309 MW;  4024AE1A5DE51E6F CRC64;
     MWRLKFSQGD INDPSLASFN NHAGRQFWEF DPLITGTPEE QALIEKARAD FRNSRYEIKQ
     SSDLLMRIQL AKENGCGAVD LEQVKVESEE EVTEEKVVIT LKRALRFYST LQAEDGHWPG
     DYGGPLFLLP GLVRILNYSV ITPPLKHIIS LYIMKALKTV LPEEHTKEIC RYLYNHQNLD
     GGWGLHIEAQ SSMFCTILNY VSLRLLGQEM DGGDGAMHKA RTWILDHGGA TYTPSWGKCW
     LSVLGVYEWD GNNPLPPEIW LLPYFLPVHP GRMWCHARMV YLPMSYLYGK RFVGPINSVV
     LSLRKELYNQ DYHQIDWNLA RNQCSKEDLY FPHPLLQDVL WKCLDKFAEP LLMQWPFSKL
     RNRALTTVMK HMEYDDVNSN YVCLGPVNKV LNMLCCWIND PNSTAVKRHL SRIKDYLWVA
     EDGMKMNGYN GSQLWDTVFA VQAIVGTNLP QEYGLMLKKA HQFIKISQMR KDSAGDLSLW
     YRHRCKGGWP FSTSDNGWPV SDCTSEGLKA AVMLSELPLE VAGEGLEQNK LYDSVDLILS
     LQNSNGGFAS YELTRSYAWL EVINPSETFG DIVIDYQYVE CTSAAIQGLK QFNKLYPNYR
     RKDIDTCIDK AVDFIESIQL SDGSWYGSWA VCYTYGTWFG ITGLIKGGKT YENSLAVRKG
     CEFLLSKQLP SGGWGESYLS SQDKVYTNIG KDVSHIVNTG WAMLALIEAG QAKRDPNPLH
     RAAKVLINSQ MENGDFPQQE IIGVFNKNCM ISYSAYRNIF PIWALGAYLN KVLKS
//