ID A0A022QRB0_ERYGU Unreviewed; 676 AA.
AC A0A022QRB0;
DT 11-JUN-2014, integrated into UniProtKB/TrEMBL.
DT 11-JUN-2014, sequence version 1.
DT 27-MAR-2024, entry version 39.
DE RecName: Full=Acyl-coenzyme A oxidase {ECO:0000256|PIRNR:PIRNR000168};
GN ORFNames=MIMGU_mgv1a002427mg {ECO:0000313|EMBL:EYU29818.1};
OS Erythranthe guttata (Yellow monkey flower) (Mimulus guttatus).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC asterids; lamiids; Lamiales; Phrymaceae; Erythranthe.
OX NCBI_TaxID=4155 {ECO:0000313|EMBL:EYU29818.1, ECO:0000313|Proteomes:UP000030748};
RN [1] {ECO:0000313|EMBL:EYU29818.1, ECO:0000313|Proteomes:UP000030748}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. DUN x IM62 {ECO:0000313|Proteomes:UP000030748};
RX PubMed=24225854; DOI=10.1073/pnas.1319032110;
RA Hellsten U., Wright K.M., Jenkins J., Shu S., Yuan Y., Wessler S.R.,
RA Schmutz J., Willis J.H., Rokhsar D.S.;
RT "Fine-scale variation in meiotic recombination in Mimulus inferred from
RT population shotgun sequencing.";
RL Proc. Natl. Acad. Sci. U.S.A. 110:19478-19482(2013).
CC -!- COFACTOR:
CC Name=FAD; Xref=ChEBI:CHEBI:57692;
CC Evidence={ECO:0000256|ARBA:ARBA00001974};
CC -!- PATHWAY: Lipid metabolism; peroxisomal fatty acid beta-oxidation.
CC {ECO:0000256|ARBA:ARBA00004846}.
CC -!- SIMILARITY: Belongs to the acyl-CoA oxidase family.
CC {ECO:0000256|ARBA:ARBA00006288, ECO:0000256|PIRNR:PIRNR000168}.
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DR EMBL; KI631145; EYU29818.1; -; Genomic_DNA.
DR RefSeq; XP_012846404.1; XM_012990950.1.
DR AlphaFoldDB; A0A022QRB0; -.
DR STRING; 4155.A0A022QRB0; -.
DR GeneID; 105966392; -.
DR KEGG; egt:105966392; -.
DR eggNOG; KOG0135; Eukaryota.
DR OMA; VMPNIQI; -.
DR OrthoDB; 5473219at2759; -.
DR PhylomeDB; A0A022QRB0; -.
DR Proteomes; UP000030748; Unassembled WGS sequence.
DR GO; GO:0005777; C:peroxisome; IBA:GO_Central.
DR GO; GO:0003997; F:acyl-CoA oxidase activity; IBA:GO_Central.
DR GO; GO:0071949; F:FAD binding; IEA:InterPro.
DR GO; GO:0005504; F:fatty acid binding; IBA:GO_Central.
DR GO; GO:0050660; F:flavin adenine dinucleotide binding; IBA:GO_Central.
DR GO; GO:0033540; P:fatty acid beta-oxidation using acyl-CoA oxidase; IBA:GO_Central.
DR GO; GO:0055088; P:lipid homeostasis; IBA:GO_Central.
DR Gene3D; 2.40.110.10; Butyryl-CoA Dehydrogenase, subunit A, domain 2; 1.
DR Gene3D; 1.20.140.10; Butyryl-CoA Dehydrogenase, subunit A, domain 3; 2.
DR InterPro; IPR006091; Acyl-CoA_Oxase/DH_mid-dom.
DR InterPro; IPR046373; Acyl-CoA_Oxase/DH_mid-dom_sf.
DR InterPro; IPR012258; Acyl-CoA_oxidase.
DR InterPro; IPR002655; Acyl-CoA_oxidase_C.
DR InterPro; IPR036250; AcylCo_DH-like_C.
DR InterPro; IPR009075; AcylCo_DH/oxidase_C.
DR InterPro; IPR009100; AcylCoA_DH/oxidase_NM_dom_sf.
DR PANTHER; PTHR10909; ELECTRON TRANSPORT OXIDOREDUCTASE; 1.
DR PANTHER; PTHR10909:SF352; PEROXISOMAL ACYL-COENZYME A OXIDASE 3; 1.
DR Pfam; PF01756; ACOX; 1.
DR Pfam; PF00441; Acyl-CoA_dh_1; 1.
DR Pfam; PF02770; Acyl-CoA_dh_M; 1.
DR PIRSF; PIRSF000168; Acyl-CoA_oxidase; 1.
DR SUPFAM; SSF47203; Acyl-CoA dehydrogenase C-terminal domain-like; 2.
DR SUPFAM; SSF56645; Acyl-CoA dehydrogenase NM domain-like; 1.
PE 3: Inferred from homology;
KW FAD {ECO:0000256|ARBA:ARBA00022827, ECO:0000256|PIRNR:PIRNR000168};
KW Flavoprotein {ECO:0000256|ARBA:ARBA00022630,
KW ECO:0000256|PIRNR:PIRNR000168};
KW Reference proteome {ECO:0000313|Proteomes:UP000030748}.
FT DOMAIN 184..293
FT /note="Acyl-CoA oxidase/dehydrogenase middle"
FT /evidence="ECO:0000259|Pfam:PF02770"
FT DOMAIN 325..482
FT /note="Acyl-CoA dehydrogenase/oxidase C-terminal"
FT /evidence="ECO:0000259|Pfam:PF00441"
FT DOMAIN 534..658
FT /note="Acyl-CoA oxidase C-terminal"
FT /evidence="ECO:0000259|Pfam:PF01756"
FT ACT_SITE 467
FT /note="Proton acceptor"
FT /evidence="ECO:0000256|PIRSR:PIRSR000168-1"
FT BINDING 188
FT /ligand="FAD"
FT /ligand_id="ChEBI:CHEBI:57692"
FT /evidence="ECO:0000256|PIRSR:PIRSR000168-2"
FT BINDING 227
FT /ligand="FAD"
FT /ligand_id="ChEBI:CHEBI:57692"
FT /evidence="ECO:0000256|PIRSR:PIRSR000168-2"
SQ SEQUENCE 676 AA; 75703 MW; D348E4827ACD645F CRC64;
MEKFNFRTQV LIRHLQQTTA TATAAAISRS PCLSYAPPET SEPPSPFDVS SMRKLMDGHN
LVDRDWVFNL MIQSKLFNPK MRGGKVFVVP DYNQSMEQQR EITMKRIQYL LDHGVFDGWL
TGRGFESEMR KLALLEVIEI FDHSLAIKIG VHFFLWGGAI QFFGTKRHHD KWLSATENYL
IKGCFSMTEL GHGSNVRGIE TVTTYDSKSG EFVINTPCES AQKYWIGGAA NHATHTVVFS
QLNVDGKNEG VHAFITQIRD ADGNICPNIR IADCGHKIGL NGVDNGRIWF DNVRIPRENL
LNSVADVSPD GKYLSAIKDP DQRFGAFMAP LTSGRVTIAA SAVYSAKISL AIAIRYSLTR
RAFSITPDSA EVLLLDYPSH QHRLLPLLAK TYAMSFAANH LKLLYVKRTP QLIKTLHVVS
SSFKAILTWH NMRTLQECRE ACGGQGLKTE NRIGQLKGEF DVQSTFEGDN NVLMQQVSKA
LLGEYLAAKK RNKPFKDLGL DHMNKSCPTI PLQLTASTVR SVQFQNDILC LRERDLLNHF
AAQVSKYQAQ GESKESAVIA SYRLAEDLGR AFSDRAIFQT FVEAENNVTD VPLKNILSVL
RSMYVLVTLD EDAAFLRYGY LTVENAETVR KEVANLCSEM RPHALALVTS FGIPDAFLSP
IAFDWIAANS WSPEQD
//
