ID A0A022R0D6_ERYGU Unreviewed; 471 AA.
AC A0A022R0D6;
DT 11-JUN-2014, integrated into UniProtKB/TrEMBL.
DT 11-JUN-2014, sequence version 1.
DT 27-MAR-2024, entry version 27.
DE RecName: Full=Tyrosinase copper-binding domain-containing protein {ECO:0000259|PROSITE:PS00497, ECO:0000259|PROSITE:PS00498};
GN ORFNames=MIMGU_mgv1a005754mg {ECO:0000313|EMBL:EYU34162.1};
OS Erythranthe guttata (Yellow monkey flower) (Mimulus guttatus).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC asterids; lamiids; Lamiales; Phrymaceae; Erythranthe.
OX NCBI_TaxID=4155 {ECO:0000313|EMBL:EYU34162.1, ECO:0000313|Proteomes:UP000030748};
RN [1] {ECO:0000313|EMBL:EYU34162.1, ECO:0000313|Proteomes:UP000030748}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. DUN x IM62 {ECO:0000313|Proteomes:UP000030748};
RX PubMed=24225854; DOI=10.1073/pnas.1319032110;
RA Hellsten U., Wright K.M., Jenkins J., Shu S., Yuan Y., Wessler S.R.,
RA Schmutz J., Willis J.H., Rokhsar D.S.;
RT "Fine-scale variation in meiotic recombination in Mimulus inferred from
RT population shotgun sequencing.";
RL Proc. Natl. Acad. Sci. U.S.A. 110:19478-19482(2013).
CC -!- COFACTOR:
CC Name=Cu(2+); Xref=ChEBI:CHEBI:29036;
CC Evidence={ECO:0000256|ARBA:ARBA00001973};
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DR EMBL; KI630717; EYU34162.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A022R0D6; -.
DR STRING; 4155.A0A022R0D6; -.
DR eggNOG; ENOG502QVBP; Eukaryota.
DR Proteomes; UP000030748; Unassembled WGS sequence.
DR GO; GO:0004097; F:catechol oxidase activity; IEA:InterPro.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR Gene3D; 1.10.1280.10; Di-copper center containing domain from catechol oxidase; 1.
DR InterPro; IPR008922; Di-copper_centre_dom_sf.
DR InterPro; IPR022740; Polyphenol_oxidase_C.
DR InterPro; IPR022739; Polyphenol_oxidase_cen.
DR InterPro; IPR002227; Tyrosinase_Cu-bd.
DR PANTHER; PTHR11474:SF87; POLYPHENOL OXIDASE CHLOROPLASTIC; 1.
DR PANTHER; PTHR11474; TYROSINASE FAMILY MEMBER; 1.
DR Pfam; PF12142; PPO1_DWL; 1.
DR Pfam; PF12143; PPO1_KFDV; 1.
DR Pfam; PF00264; Tyrosinase; 1.
DR PRINTS; PR00092; TYROSINASE.
DR SUPFAM; SSF48056; Di-copper centre-containing domain; 1.
DR PROSITE; PS00497; TYROSINASE_1; 1.
DR PROSITE; PS00498; TYROSINASE_2; 1.
PE 4: Predicted;
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Oxidoreductase {ECO:0000256|ARBA:ARBA00023002};
KW Reference proteome {ECO:0000313|Proteomes:UP000030748};
KW Thioether bond {ECO:0000256|ARBA:ARBA00022784}.
FT DOMAIN 64..81
FT /note="Tyrosinase copper-binding"
FT /evidence="ECO:0000259|PROSITE:PS00497"
FT DOMAIN 220..231
FT /note="Tyrosinase copper-binding"
FT /evidence="ECO:0000259|PROSITE:PS00498"
SQ SEQUENCE 471 AA; 53800 MW; F7AD5EEFBE4C580E CRC64;
MKIRPSAHRV SAEYMYKYNL ATDRMKRLPA DDPRNFMQQA NVHCAYCNAA YDQPGQGALQ
IQIHKCWLFF PFHRWYLYFY ERILGKLIGD PTFALPFWNW DHPRGMTMPP MFVEDPRSAL
YDRKRNQKHL PPAVVDLGKT DSTDTLQLVS NNLTIMHNEM IRCISDPLDF MGARYCEGSE
ANPGEGSVES GSHTVIHSWV GDPEQPTSED LGNFYSAARD PLFYCHHANV DRMWYLWQRL
PNNKLPNKRI TDPDYLNASF LFYDENAQLV KVYVRDTFDN RRMGFDYERI DLPWVDYRPP
PQAARTKINK VVDAPNAKTL FPLKLDGVVR FQVDKTKKGK ADEILVLENI TVDASKMIKF
DVFVNDEDDN PSELDKASYL GSYAQLPHKP RSGTTSTSSR IRLRLTDLYD DIDIGDDDAI
VVTLVPRQQG PGVTIGGIKI IENPTKPNPT AAAAADADTT TTTTTMIRFI I
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