ID   A0A022RPK0_ERYGU        Unreviewed;       833 AA.
AC   A0A022RPK0;
DT   11-JUN-2014, integrated into UniProtKB/TrEMBL.
DT   11-JUN-2014, sequence version 1.
DT   27-MAR-2024, entry version 34.
DE   RecName: Full=AMP deaminase {ECO:0000256|ARBA:ARBA00012775};
DE            EC=3.5.4.6 {ECO:0000256|ARBA:ARBA00012775};
GN   ORFNames=MIMGU_mgv1a001363mg {ECO:0000313|EMBL:EYU41921.1};
OS   Erythranthe guttata (Yellow monkey flower) (Mimulus guttatus).
OC   Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC   Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC   asterids; lamiids; Lamiales; Phrymaceae; Erythranthe.
OX   NCBI_TaxID=4155 {ECO:0000313|EMBL:EYU41921.1, ECO:0000313|Proteomes:UP000030748};
RN   [1] {ECO:0000313|EMBL:EYU41921.1, ECO:0000313|Proteomes:UP000030748}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=cv. DUN x IM62 {ECO:0000313|Proteomes:UP000030748};
RX   PubMed=24225854; DOI=10.1073/pnas.1319032110;
RA   Hellsten U., Wright K.M., Jenkins J., Shu S., Yuan Y., Wessler S.R.,
RA   Schmutz J., Willis J.H., Rokhsar D.S.;
RT   "Fine-scale variation in meiotic recombination in Mimulus inferred from
RT   population shotgun sequencing.";
RL   Proc. Natl. Acad. Sci. U.S.A. 110:19478-19482(2013).
CC   -!- COFACTOR:
CC       Name=Zn(2+); Xref=ChEBI:CHEBI:29105;
CC         Evidence={ECO:0000256|ARBA:ARBA00001947};
CC   -!- PATHWAY: Purine metabolism; IMP biosynthesis via salvage pathway; IMP
CC       from AMP: step 1/1. {ECO:0000256|ARBA:ARBA00004955}.
CC   -!- SIMILARITY: Belongs to the metallo-dependent hydrolases superfamily.
CC       Adenosine and AMP deaminases family. {ECO:0000256|ARBA:ARBA00006676}.
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DR   EMBL; KI630319; EYU41921.1; -; Genomic_DNA.
DR   RefSeq; XP_012832193.1; XM_012976739.1.
DR   AlphaFoldDB; A0A022RPK0; -.
DR   STRING; 4155.A0A022RPK0; -.
DR   GeneID; 105953108; -.
DR   KEGG; egt:105953108; -.
DR   eggNOG; KOG1096; Eukaryota.
DR   OMA; HVYPNRE; -.
DR   OrthoDB; 20951at2759; -.
DR   PhylomeDB; A0A022RPK0; -.
DR   UniPathway; UPA00591; UER00663.
DR   Proteomes; UP000030748; Unassembled WGS sequence.
DR   GO; GO:0005829; C:cytosol; IBA:GO_Central.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR   GO; GO:0003876; F:AMP deaminase activity; IBA:GO_Central.
DR   GO; GO:0046033; P:AMP metabolic process; IBA:GO_Central.
DR   GO; GO:0006188; P:IMP biosynthetic process; IBA:GO_Central.
DR   GO; GO:0032264; P:IMP salvage; IEA:UniProtKB-UniPathway.
DR   CDD; cd01319; AMPD; 1.
DR   Gene3D; 4.10.800.20; -; 1.
DR   Gene3D; 3.20.20.140; Metal-dependent hydrolases; 1.
DR   InterPro; IPR006650; A/AMP_deam_AS.
DR   InterPro; IPR006329; AMPD.
DR   InterPro; IPR032466; Metal_Hydrolase.
DR   NCBIfam; TIGR01429; AMP_deaminase; 1.
DR   PANTHER; PTHR11359; AMP DEAMINASE; 1.
DR   PANTHER; PTHR11359:SF0; AMP DEAMINASE; 1.
DR   Pfam; PF19326; AMP_deaminase; 1.
DR   SUPFAM; SSF51556; Metallo-dependent hydrolases; 1.
DR   PROSITE; PS00485; A_DEAMINASE; 1.
PE   3: Inferred from homology;
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000030748};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM        6..26
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   REGION          48..104
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          116..138
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        48..67
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   833 AA;  95269 MW;  EB3653E9638EC355 CRC64;
     MDAYSLHLAM AALVGASFVA VSAYYMHRKT LNQLLEFAKS IERDREDAAA GEGGADDDAE
     ERLKKYPSRR RGKGNGGYYR RGSASSPDVT TFSGGGEGEL REKRNAPVRV DSIPAGLPRL
     HTLPEGHLIR PTSPKSPVAS ASAFESLEGS DDEDIMTDNI DSTYLHTNGN ENATDHINAN
     GEQAPLATPS MIRSHSVSGD LHGVQPDPVA ADILRKEPEH ESFVQLKISP SEIPSPDEVE
     VYRTLQDCLE MRKKYVFREA VAPWEKEILS DPSTPKPILN PFDHYPVAKS DHYFRMEDGV
     VHVYSNKDSK EKLFPVADAT TFFTDLHHIL KVIAAGNIRT LCHHRLVLLE QKFNLHLMLN
     ADREFLAQKS APHRDFYNVR KVDTHVHHSA CMNQKHLLRF IKSKLRKEPD EVVIFRDGTY
     LTLKEVFESL DLTGYDLNVD LLDVHADKST FHRFDKFNLK YNPCGQSRLR EIFLKQDNLI
     QGRFLAEVTK QVFSDLETSK YQMAEYRISI YGRKMSEWDQ MASWIVNNDL YSENVVWLIQ
     LPRLYNIYKE MGIVTSFQNI LDNIFLPLFE VTIDPDSHPQ LHVFLKQVVG LDLVDDESKP
     ERRPTKHMPT PAQWTNIFNP AFSYYAYYCY ANLYTLNKLR ESKGMTTIKF RPHSGEAGDI
     DHLATTFLTA HNIAHGINLR KSPVLQYLYY LAQIGLAMSP LSNNSLFLDY HRNPLPMFFL
     RGLNVSLSTD DPLQIHLTKE PLVEEYSIAA SVWKLSSCDL CEIARNSVYQ SGFSHALKSH
     WIGKQYFKRG PDGNDIHKTN VPHIRLEFRE MIWREEMQQV YLGRANFPKF IDP
//