ID A0A022RSY2_ERYGU Unreviewed; 735 AA.
AC A0A022RSY2;
DT 11-JUN-2014, integrated into UniProtKB/TrEMBL.
DT 11-JUN-2014, sequence version 1.
DT 27-MAR-2024, entry version 29.
DE RecName: Full=NB-ARC domain-containing protein {ECO:0000259|Pfam:PF00931};
DE Flags: Fragment;
GN ORFNames=MIMGU_mgv1a017964mg {ECO:0000313|EMBL:EYU43101.1};
OS Erythranthe guttata (Yellow monkey flower) (Mimulus guttatus).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC asterids; lamiids; Lamiales; Phrymaceae; Erythranthe.
OX NCBI_TaxID=4155 {ECO:0000313|EMBL:EYU43101.1, ECO:0000313|Proteomes:UP000030748};
RN [1] {ECO:0000313|EMBL:EYU43101.1, ECO:0000313|Proteomes:UP000030748}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. DUN x IM62 {ECO:0000313|Proteomes:UP000030748};
RX PubMed=24225854; DOI=10.1073/pnas.1319032110;
RA Hellsten U., Wright K.M., Jenkins J., Shu S., Yuan Y., Wessler S.R.,
RA Schmutz J., Willis J.H., Rokhsar D.S.;
RT "Fine-scale variation in meiotic recombination in Mimulus inferred from
RT population shotgun sequencing.";
RL Proc. Natl. Acad. Sci. U.S.A. 110:19478-19482(2013).
CC -!- FUNCTION: Confers resistance to late blight (Phytophthora infestans)
CC races carrying the avirulence gene Avr1. Resistance proteins guard the
CC plant against pathogens that contain an appropriate avirulence protein
CC via an indirect interaction with this avirulence protein. That triggers
CC a defense system including the hypersensitive response, which restricts
CC the pathogen growth. {ECO:0000256|ARBA:ARBA00002074}.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004170};
CC Peripheral membrane protein {ECO:0000256|ARBA:ARBA00004170}.
CC -!- SIMILARITY: Belongs to the disease resistance NB-LRR family.
CC {ECO:0000256|ARBA:ARBA00008894}.
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DR EMBL; KI630264; EYU43101.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A022RSY2; -.
DR eggNOG; KOG4658; Eukaryota.
DR Proteomes; UP000030748; Unassembled WGS sequence.
DR GO; GO:0043531; F:ADP binding; IEA:InterPro.
DR GO; GO:0006952; P:defense response; IEA:UniProtKB-KW.
DR GO; GO:0051707; P:response to other organism; IEA:UniProt.
DR Gene3D; 1.10.8.430; Helical domain of apoptotic protease-activating factors; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR Gene3D; 3.80.10.10; Ribonuclease Inhibitor; 1.
DR Gene3D; 1.10.10.10; Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain; 1.
DR InterPro; IPR042197; Apaf_helical.
DR InterPro; IPR044974; Disease_R_plants.
DR InterPro; IPR032675; LRR_dom_sf.
DR InterPro; IPR002182; NB-ARC.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR036388; WH-like_DNA-bd_sf.
DR PANTHER; PTHR23155; DISEASE RESISTANCE PROTEIN RP; 1.
DR PANTHER; PTHR23155:SF1235; DISEASE RESISTANCE RPP13-LIKE PROTEIN 1; 1.
DR Pfam; PF00931; NB-ARC; 1.
DR PRINTS; PR00364; DISEASERSIST.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR SUPFAM; SSF52047; RNI-like; 1.
PE 3: Inferred from homology;
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Hypersensitive response {ECO:0000256|ARBA:ARBA00022667};
KW Membrane {ECO:0000256|ARBA:ARBA00023136};
KW Plant defense {ECO:0000256|ARBA:ARBA00022821};
KW Reference proteome {ECO:0000313|Proteomes:UP000030748}.
FT DOMAIN 26..266
FT /note="NB-ARC"
FT /evidence="ECO:0000259|Pfam:PF00931"
FT NON_TER 1
FT /evidence="ECO:0000313|EMBL:EYU43101.1"
SQ SEQUENCE 735 AA; 85181 MW; 864D47D9F13934B1 CRC64;
YSKKNSSSSY YNTCNKQHNL LVGLDDQIRA LKQWIFDPIS HDLVKSVVGM TGIGKTTLVK
QVYNDPRVVK EFETRLFLHI GPSYNLLEDI LLLVLNQLGV NISDNVVDDK YDYLKKRLRE
ALSSKKYLIV LDDVWSVFRH ELKYDAFPNN TRESRVIIIS HVQPVRYYNY ETHDFLVPLL
KDEESWKLLR QTAFSNSEEK CNRELEKIGK QIARNCEGLP AAIIQVGENL RGKSFEEWKT
LSENEDPFVI TRDDNTPLSM SLYFSYLMLP QYLKASFLYI GVFPKHYGIS RSKLIKLWLS
EDLVIHGYDE EKTVGDDLDL LIRHAVVLGE KQTSVDSRST KSCRLHFTFR SLCVNEAKSE
KFFHILKKYT DCEPENIQRQ QRLCVHNNVV LAFTQVHEWM ESVPNARSLL CYGPKQQYPV
LLPLCLRLLK ILDALAIRFY EFPHQVLALI HLRYFAITCD GELPNSISRL WNLEVLILGQ
HHNIKLWNNG PVYLPIEIWN MHKLKELYCK GFDLPTPPLG DSYLQNLFTI SGVSVHSCTM
EVLSRIPKLK RIAVQIESAH ESIETFSFFG HFATRYDEFE SLKCVVVNPN LSSHVVRCVP
KFPMNITKIS LHGCGLPWKN MGVIAALPYL KVLKLRWYAF CGPHWIVNSG EFPRLRILLL
EDLDIEHWES NNKGLQRSGL HPEHLIVKHC YKLKNIPGRF LAGIVEVDDC SISLVEKMRE
WRSIDVKIHS STTDL
//
