ID A0A022RT53_ERYGU Unreviewed; 924 AA.
AC A0A022RT53;
DT 11-JUN-2014, integrated into UniProtKB/TrEMBL.
DT 11-JUN-2014, sequence version 1.
DT 24-JAN-2024, entry version 28.
DE RecName: Full=Cation-chloride cotransporter 1 {ECO:0008006|Google:ProtNLM};
GN ORFNames=MIMGU_mgv1a000978mg {ECO:0000313|EMBL:EYU43239.1};
OS Erythranthe guttata (Yellow monkey flower) (Mimulus guttatus).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC asterids; lamiids; Lamiales; Phrymaceae; Erythranthe.
OX NCBI_TaxID=4155 {ECO:0000313|EMBL:EYU43239.1, ECO:0000313|Proteomes:UP000030748};
RN [1] {ECO:0000313|EMBL:EYU43239.1, ECO:0000313|Proteomes:UP000030748}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. DUN x IM62 {ECO:0000313|Proteomes:UP000030748};
RX PubMed=24225854; DOI=10.1073/pnas.1319032110;
RA Hellsten U., Wright K.M., Jenkins J., Shu S., Yuan Y., Wessler S.R.,
RA Schmutz J., Willis J.H., Rokhsar D.S.;
RT "Fine-scale variation in meiotic recombination in Mimulus inferred from
RT population shotgun sequencing.";
RL Proc. Natl. Acad. Sci. U.S.A. 110:19478-19482(2013).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
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DR EMBL; KI630264; EYU43239.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A022RT53; -.
DR STRING; 4155.A0A022RT53; -.
DR eggNOG; KOG2082; Eukaryota.
DR Proteomes; UP000030748; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0015377; F:chloride:monoatomic cation symporter activity; IEA:InterPro.
DR Gene3D; 1.20.1740.10; Amino acid/polyamine transporter I; 1.
DR InterPro; IPR004841; AA-permease/SLC12A_dom.
DR InterPro; IPR018491; SLC12_C.
DR InterPro; IPR004842; SLC12A_fam.
DR NCBIfam; TIGR00930; 2a30; 1.
DR PANTHER; PTHR11827:SF100; CATION-CHLORIDE COTRANSPORTER 1; 1.
DR PANTHER; PTHR11827; SOLUTE CARRIER FAMILY 12, CATION COTRANSPORTERS; 1.
DR Pfam; PF00324; AA_permease; 1.
DR Pfam; PF03522; SLC12; 2.
PE 4: Predicted;
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000030748};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 77..98
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 113..135
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 156..177
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 219..238
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 245..266
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 306..326
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 346..367
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 382..403
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 438..459
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 465..484
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 505..534
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 82..553
FT /note="Amino acid permease/ SLC12A"
FT /evidence="ECO:0000259|Pfam:PF00324"
FT DOMAIN 594..715
FT /note="SLC12A transporter C-terminal"
FT /evidence="ECO:0000259|Pfam:PF03522"
FT DOMAIN 726..923
FT /note="SLC12A transporter C-terminal"
FT /evidence="ECO:0000259|Pfam:PF03522"
FT REGION 1..24
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 924 AA; 101425 MW; 61C4D42024FD799F CRC64;
MPQNMNSEAR DRSLPSHGGV NGSQTESKLE LFGFDSLVNI LGLKSMAGDQ AQTPLSPVDG
DDIPVNVERP QASSVKLGTM MGVFVPCLQN ILGIIYYIRF SWIVGMAGIG QSLLLVAFCG
SCTFLTTISL SAIATNGAMK GGGPYYLIGR ALGPEVGVSI GLCFFLGNAV AGALYVLGAV
ETFLNALPQA GIFRDTQTFV KVNGTDVAQP ITSPSLHDLQ VYGIIVTIIL CFIVFGGVKM
INRVAPAFLL PVVFSLFCIF VGIFLARTNY PAEGITGLSL QSFKDNWGSE YQMTNNAGIP
DPTGKIYWNF NALVGLFFPA VTGIMAGSNR SASLKDTQRS IPVGTLAATL ATTILYLVTV
LFFGALATRD KLLTDRLLTA TVAWPVPAIT YIGIILSTLG AALQSLTGAP RLLAAIANDD
ILPVLNYFKV ADGSEPHVAT LFTAFLCIGC VIIGNLDLIT PTVTMFYLLC YGGVNLSCFL
LDLLDAPSWR PRWKFHHWSL SLIGASICIV IMFLISWAFT VVSLALASLI YYYVSIKGKA
GDWGDGFKSA YFQLALRSLR SLGASQVHPK NWYPIPLIFC RPWGKLPENV PCHPKLADFA
NFMKKKGRGM SIFVSILDGE YHECAEDAKA ACRALSTYIE YKKCEGVAEI VVAPSMSDGF
RGIVQTMGLG NLKPNIVVMR YPEIWRRENL TEIPATFVGI INDCIVANKA VVIVKGLDEW
PNEYQRQYGT IDLYWIVRDG GLMLLLSQLL LTKESFESCK IQVFCIAEED SDAEELKADV
KKFLYDLRMQ AEVIVISMKS WDIAQAEQQD ESVEAFSLAR ERISGYLAEM KGRAEREGRP
LMADGKNVVV NEAQVEKFLY TTLKLNSTIL RYSRMSAVVL VSLPPPPLNH PAYFYMEYMD
LLVENVPRLL MVRGYRRDVV TLFT
//
