ID A0A022RZB7_ERYGU Unreviewed; 788 AA.
AC A0A022RZB7;
DT 11-JUN-2014, integrated into UniProtKB/TrEMBL.
DT 11-JUN-2014, sequence version 1.
DT 24-JAN-2024, entry version 42.
DE RecName: Full=CBS domain-containing protein {ECO:0000259|SMART:SM00116};
GN ORFNames=MIMGU_mgv1a001597mg {ECO:0000313|EMBL:EYU45399.1};
OS Erythranthe guttata (Yellow monkey flower) (Mimulus guttatus).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC asterids; lamiids; Lamiales; Phrymaceae; Erythranthe.
OX NCBI_TaxID=4155 {ECO:0000313|EMBL:EYU45399.1, ECO:0000313|Proteomes:UP000030748};
RN [1] {ECO:0000313|EMBL:EYU45399.1, ECO:0000313|Proteomes:UP000030748}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. DUN x IM62 {ECO:0000313|Proteomes:UP000030748};
RX PubMed=24225854; DOI=10.1073/pnas.1319032110;
RA Hellsten U., Wright K.M., Jenkins J., Shu S., Yuan Y., Wessler S.R.,
RA Schmutz J., Willis J.H., Rokhsar D.S.;
RT "Fine-scale variation in meiotic recombination in Mimulus inferred from
RT population shotgun sequencing.";
RL Proc. Natl. Acad. Sci. U.S.A. 110:19478-19482(2013).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the chloride channel (TC 2.A.49) family.
CC {ECO:0000256|ARBA:ARBA00009476}.
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DR EMBL; KI630190; EYU45399.1; -; Genomic_DNA.
DR RefSeq; XP_012844151.1; XM_012988697.1.
DR AlphaFoldDB; A0A022RZB7; -.
DR STRING; 4155.A0A022RZB7; -.
DR GeneID; 105964172; -.
DR KEGG; egt:105964172; -.
DR eggNOG; KOG0474; Eukaryota.
DR OMA; FARIDHG; -.
DR OrthoDB; 315083at2759; -.
DR PhylomeDB; A0A022RZB7; -.
DR Proteomes; UP000030748; Unassembled WGS sequence.
DR GO; GO:0043231; C:intracellular membrane-bounded organelle; IBA:GO_Central.
DR GO; GO:0009705; C:plant-type vacuole membrane; IBA:GO_Central.
DR GO; GO:0009671; F:nitrate:proton symporter activity; IBA:GO_Central.
DR GO; GO:0005247; F:voltage-gated chloride channel activity; IEA:InterPro.
DR CDD; cd04591; CBS_pair_voltage-gated_CLC_euk_bac; 1.
DR CDD; cd03685; ClC_6_like; 1.
DR Gene3D; 1.10.3080.10; Clc chloride channel; 1.
DR InterPro; IPR000644; CBS_dom.
DR InterPro; IPR046342; CBS_dom_sf.
DR InterPro; IPR014743; Cl-channel_core.
DR InterPro; IPR001807; Cl-channel_volt-gated.
DR InterPro; IPR002251; Cl_channel_pln.
DR PANTHER; PTHR11689; CHLORIDE CHANNEL PROTEIN CLC FAMILY MEMBER; 1.
DR PANTHER; PTHR11689:SF67; CHLORIDE CHANNEL PROTEIN CLC-A; 1.
DR Pfam; PF00654; Voltage_CLC; 1.
DR PRINTS; PR00762; CLCHANNEL.
DR PRINTS; PR01120; CLCHANNELPLT.
DR SMART; SM00116; CBS; 2.
DR SUPFAM; SSF54631; CBS-domain pair; 1.
DR SUPFAM; SSF81340; Clc chloride channel; 1.
PE 3: Inferred from homology;
KW Ion channel {ECO:0000256|ARBA:ARBA00023303};
KW Ion transport {ECO:0000256|ARBA:ARBA00023303};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000030748};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|ARBA:ARBA00023303}.
FT TRANSMEM 85..111
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 131..157
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 282..301
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 334..354
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 458..491
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 544..561
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 603..663
FT /note="CBS"
FT /evidence="ECO:0000259|SMART:SM00116"
FT DOMAIN 718..771
FT /note="CBS"
FT /evidence="ECO:0000259|SMART:SM00116"
SQ SEQUENCE 788 AA; 86406 MW; 90D1F56AFDA9308A CRC64;
MEKLNKLLEA EATNIERPDE EEGRDCSSNN LHQSLLKRNR TLSSNQLAFV GTKVSHIESL
DYEINENDLF KQDWRSRSKV QVLQYIFLKW LLAFLVGLLT GVIATLINLA VENIAGYKLR
AVVKYIDQER YLMGFVYMAG ANFLLTFVAA ILCVCFAPTA AGPGIPEIKA YLNGVDTPDM
FGATQLIVKI IGSIGAVSAG LDLGKEGPLV HIGSCIAALL GQGGTEKYRI RWRWLRYFNN
DRDRRDLITC GSSSGVCAAF RSPVGGVLFA LEEVATWWRS ALLWRTFFST AVVVVVLRAA
MEYCKSGECG LFGKGGLIMF DVSGVSVRYH VVDIIPVAVI GVVGGVLGSL YNYLLHKVLK
VYNVINKKGK VPKLILSLSV SIFTSVCLYG LPFLAKCQPC DPSLPDSSSC PNTGGAGNFK
QFNCPSGYYN DLATLLLTTN DDAVRSIFSI NTATEYNIVS LIIFFLLYCI LGLITFGIAV
PSGLFLPIIL MGSAYGRLLG MAMGPYTRID QGLYAVLGAA SLMAGSMRMT VSLCVIFLEL
TNNLLLLPIT MLVLLIAKTV GDCFNPSIYD IILELKGLPF LDANPEPWMR NITAGELADA
KPAIVTLNGV EKVGRIVEVL KNTTYNGFPV VDCGVTTSMG SSPNGANELH GLILRAHLLL
VLKKKLFLKE RRRTQEWEVI EKFTCMDLAE RGATIEEVTV SKDEMEMYVD LHPLTNTTPY
TVVESISVAK AMVLFRQLAL RHMLILPKYQ AAGVSPVVGI LTRQDLIAHN ILSAFPHLEK
SKANKKGH
//
