ID   A0A023B881_GRENI        Unreviewed;       805 AA.
AC   A0A023B881;
DT   11-JUN-2014, integrated into UniProtKB/TrEMBL.
DT   11-JUN-2014, sequence version 1.
DT   27-MAR-2024, entry version 34.
DE   SubName: Full=ATP-dependent metalloprotease {ECO:0000313|EMBL:EZG68305.1};
GN   ORFNames=GNI_062730 {ECO:0000313|EMBL:EZG68305.1};
OS   Gregarina niphandrodes (Septate eugregarine).
OC   Eukaryota; Sar; Alveolata; Apicomplexa; Conoidasida; Gregarinasina;
OC   Eugregarinorida; Gregarinidae; Gregarina.
OX   NCBI_TaxID=110365 {ECO:0000313|EMBL:EZG68305.1, ECO:0000313|Proteomes:UP000019763};
RN   [1] {ECO:0000313|EMBL:EZG68305.1, ECO:0000313|Proteomes:UP000019763}
RP   NUCLEOTIDE SEQUENCE.
RA   Omoto C.K., Sibley D., Venepally P., Hadjithomas M., Karamycheva S.,
RA   Brunk B., Roos D., Caler E., Lorenzi H.;
RL   Submitted (DEC-2013) to the EMBL/GenBank/DDBJ databases.
CC   -!- COFACTOR:
CC       Name=Zn(2+); Xref=ChEBI:CHEBI:29105;
CC         Evidence={ECO:0000256|ARBA:ARBA00001947};
CC   -!- SIMILARITY: In the C-terminal section; belongs to the peptidase M41
CC       family. {ECO:0000256|ARBA:ARBA00010044}.
CC   -!- SIMILARITY: In the N-terminal section; belongs to the AAA ATPase
CC       family. {ECO:0000256|ARBA:ARBA00010550}.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:EZG68305.1}.
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DR   EMBL; AFNH02000475; EZG68305.1; -; Genomic_DNA.
DR   RefSeq; XP_011134591.1; XM_011136289.1.
DR   AlphaFoldDB; A0A023B881; -.
DR   EnsemblProtists; EZG68305; EZG68305; GNI_062730.
DR   GeneID; 22912294; -.
DR   VEuPathDB; CryptoDB:GNI_062730; -.
DR   eggNOG; KOG0731; Eukaryota.
DR   OrthoDB; 9585at2759; -.
DR   Proteomes; UP000019763; Unassembled WGS sequence.
DR   GO; GO:0005524; F:ATP binding; IEA:InterPro.
DR   GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR   GO; GO:0004176; F:ATP-dependent peptidase activity; IEA:InterPro.
DR   GO; GO:0004222; F:metalloendopeptidase activity; IEA:InterPro.
DR   GO; GO:0006508; P:proteolysis; IEA:UniProtKB-KW.
DR   CDD; cd19501; RecA-like_FtsH; 1.
DR   Gene3D; 1.10.8.60; -; 1.
DR   Gene3D; 3.40.1690.20; -; 1.
DR   Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR   Gene3D; 1.20.58.760; Peptidase M41; 1.
DR   InterPro; IPR003593; AAA+_ATPase.
DR   InterPro; IPR041569; AAA_lid_3.
DR   InterPro; IPR003959; ATPase_AAA_core.
DR   InterPro; IPR003960; ATPase_AAA_CS.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR000642; Peptidase_M41.
DR   InterPro; IPR037219; Peptidase_M41-like.
DR   PANTHER; PTHR43655; ATP-DEPENDENT PROTEASE; 1.
DR   PANTHER; PTHR43655:SF2; SD01613P; 1.
DR   Pfam; PF00004; AAA; 1.
DR   Pfam; PF17862; AAA_lid_3; 1.
DR   Pfam; PF01434; Peptidase_M41; 1.
DR   SMART; SM00382; AAA; 1.
DR   SUPFAM; SSF140990; FtsH protease domain-like; 1.
DR   SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR   PROSITE; PS00674; AAA; 1.
PE   3: Inferred from homology;
KW   Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW   Metalloprotease {ECO:0000313|EMBL:EZG68305.1};
KW   Protease {ECO:0000256|ARBA:ARBA00022670, ECO:0000313|EMBL:EZG68305.1};
KW   Reference proteome {ECO:0000313|Proteomes:UP000019763}.
FT   DOMAIN          348..490
FT                   /note="AAA+ ATPase"
FT                   /evidence="ECO:0000259|SMART:SM00382"
FT   REGION          31..53
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          163..183
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   805 AA;  88829 MW;  4E3F682665B85BCB CRC64;
     MLPGKVKWTT GISFLGQIGA KSLLRAADTT SNFRKGSGRP LLPPRRRLTN DIPPLLTPPT
     PRINTIELPL LSVITIFASL GLWLLTGEHD RVKAESMISM KEFMYDYLRR GKVDRLQVIG
     QDHVRVVLKD EQPFDLNGCI DGVVKAIEVL GGKAADALGM KLSSGGTRDG DGGPKASVRE
     QGERRKSLRR ALYGHLVRLV RAEDFAEDKR FVRFKVGDLN QLETLLRLYT SKIPPVYYLD
     CKDRIQTLRN VLPSVALAAM SFVRVRRSQP ETLARLHRDY YDRANAPTQT QLPDNLLKFG
     QAQHKPPGEV PNVRFSDVAG LEQAKLEVQE FVDFLKHPEK YTSLGAQIPK GALLVGPPGT
     GKTLLARAIA GEAGVPFYST SGSDFIEMFV GVGASRIRDL FAKARKNAPA IVFIDEIDTI
     GRARAGANHL GNGGTDERES TLNALLVELD GFSANANVIT LAGTNRGDVL DRALTRPGRF
     DRQIALAKPS IKERLAIFEI YLRPLKLEDG MRGVAQRLAA LTPGFSGAEI KNVCNEGAIL
     AARRDADSVA LGDLEQAVER LVGGLRHTGD VLSPELRAQV ALHEAGHAVA AWFLPEADPV
     LKLSVVPRAS GALGYTQTLP DDLLLSKKET LEDKICTLLA GRAAEHLFSQ TVTTGASDDL
     ERATKLCQAY VQVFGFDRVL GLRSYQQNEQ SLHTTYSDAT AKQIDDRVSQ LLRYQWTRCL
     DLLTSKQREV RQLADTLLEH EVISFNDMVR YLRVIRYPRG EVGGDKISTG MGFDGCGSRS
     AFWVQRARKC RRRRVSLWRP CPVAS
//